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Article: Changes in content and secretion of pancreatic enzymes in the obese Zucker rat

TitleChanges in content and secretion of pancreatic enzymes in the obese Zucker rat
Authors
Issue Date1984
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 1984, v. 219 n. 1, p. 333-336 How to Cite?
AbstractThe contents of three major digestive enzymes (amylase, lipase and chymotrypsinogen) were measured in the obese Zucker rat. Only minimal changes were found in 7-week-old rats, but in adult obese rats (14-16 weeks) the amylase content was decreased by 50%, whereas lipase and chymotrypsinogen contents were increased by 45% and 20%, respectively, compared with lean controls. Abnormalities of enzyme secretion were also found. Since the changes observed in enzyme proportions in adult obese Zucker rats are qualitatively similar to those observed in insulinopenic diabetes and other states associated with decreased glucose metabolism, it is speculated that the abnormalities found in the obese Zucker rat may be due to decreased glucose metabolism in the exocrine tissue consequent to insulin resistance.
Persistent Identifierhttp://hdl.handle.net/10722/176239
ISSN
2015 Impact Factor: 3.562
2015 SCImago Journal Rankings: 2.582
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_US
dc.contributor.authorTrimble, ERen_US
dc.contributor.authorGjinovci, Aen_US
dc.contributor.authorRenold, AEen_US
dc.date.accessioned2012-11-26T09:07:29Z-
dc.date.available2012-11-26T09:07:29Z-
dc.date.issued1984en_US
dc.identifier.citationBiochemical Journal, 1984, v. 219 n. 1, p. 333-336en_US
dc.identifier.issn0264-6021en_US
dc.identifier.urihttp://hdl.handle.net/10722/176239-
dc.description.abstractThe contents of three major digestive enzymes (amylase, lipase and chymotrypsinogen) were measured in the obese Zucker rat. Only minimal changes were found in 7-week-old rats, but in adult obese rats (14-16 weeks) the amylase content was decreased by 50%, whereas lipase and chymotrypsinogen contents were increased by 45% and 20%, respectively, compared with lean controls. Abnormalities of enzyme secretion were also found. Since the changes observed in enzyme proportions in adult obese Zucker rats are qualitatively similar to those observed in insulinopenic diabetes and other states associated with decreased glucose metabolism, it is speculated that the abnormalities found in the obese Zucker rat may be due to decreased glucose metabolism in the exocrine tissue consequent to insulin resistance.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_US
dc.relation.ispartofBiochemical Journalen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAmylases - Metabolism - Secretionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose - Metabolismen_US
dc.subject.meshChymotrypsinogen - Metabolism - Secretionen_US
dc.subject.meshInsulin - Blooden_US
dc.subject.meshLipase - Metabolism - Secretionen_US
dc.subject.meshMaleen_US
dc.subject.meshObesity - Enzymologyen_US
dc.subject.meshPancreas - Enzymologyen_US
dc.subject.meshProteins - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Zuckeren_US
dc.titleChanges in content and secretion of pancreatic enzymes in the obese Zucker raten_US
dc.typeArticleen_US
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_US
dc.identifier.authorityBruzzone, R=rp01442en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6202297-
dc.identifier.scopuseid_2-s2.0-0021323779en_US
dc.identifier.volume219en_US
dc.identifier.issue1en_US
dc.identifier.spage333en_US
dc.identifier.epage336en_US
dc.identifier.isiWOS:A1984SL40200042-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBruzzone, R=7006793327en_US
dc.identifier.scopusauthoridTrimble, ER=7005267920en_US
dc.identifier.scopusauthoridGjinovci, A=6701391657en_US
dc.identifier.scopusauthoridRenold, AE=7005742513en_US

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