File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1042/bj2190333
- Scopus: eid_2-s2.0-0021323779
- PMID: 6202297
- WOS: WOS:A1984SL40200042
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Changes in content and secretion of pancreatic enzymes in the obese Zucker rat
Title | Changes in content and secretion of pancreatic enzymes in the obese Zucker rat |
---|---|
Authors | |
Issue Date | 1984 |
Publisher | Portland Press Ltd. The Journal's web site is located at http://www.biochemj.org |
Citation | Biochemical Journal, 1984, v. 219 n. 1, p. 333-336 How to Cite? |
Abstract | The contents of three major digestive enzymes (amylase, lipase and chymotrypsinogen) were measured in the obese Zucker rat. Only minimal changes were found in 7-week-old rats, but in adult obese rats (14-16 weeks) the amylase content was decreased by 50%, whereas lipase and chymotrypsinogen contents were increased by 45% and 20%, respectively, compared with lean controls. Abnormalities of enzyme secretion were also found. Since the changes observed in enzyme proportions in adult obese Zucker rats are qualitatively similar to those observed in insulinopenic diabetes and other states associated with decreased glucose metabolism, it is speculated that the abnormalities found in the obese Zucker rat may be due to decreased glucose metabolism in the exocrine tissue consequent to insulin resistance. |
Persistent Identifier | http://hdl.handle.net/10722/176239 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.612 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bruzzone, R | en_US |
dc.contributor.author | Trimble, ER | en_US |
dc.contributor.author | Gjinovci, A | en_US |
dc.contributor.author | Renold, AE | en_US |
dc.date.accessioned | 2012-11-26T09:07:29Z | - |
dc.date.available | 2012-11-26T09:07:29Z | - |
dc.date.issued | 1984 | en_US |
dc.identifier.citation | Biochemical Journal, 1984, v. 219 n. 1, p. 333-336 | en_US |
dc.identifier.issn | 0264-6021 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/176239 | - |
dc.description.abstract | The contents of three major digestive enzymes (amylase, lipase and chymotrypsinogen) were measured in the obese Zucker rat. Only minimal changes were found in 7-week-old rats, but in adult obese rats (14-16 weeks) the amylase content was decreased by 50%, whereas lipase and chymotrypsinogen contents were increased by 45% and 20%, respectively, compared with lean controls. Abnormalities of enzyme secretion were also found. Since the changes observed in enzyme proportions in adult obese Zucker rats are qualitatively similar to those observed in insulinopenic diabetes and other states associated with decreased glucose metabolism, it is speculated that the abnormalities found in the obese Zucker rat may be due to decreased glucose metabolism in the exocrine tissue consequent to insulin resistance. | en_US |
dc.language | eng | en_US |
dc.publisher | Portland Press Ltd. The Journal's web site is located at http://www.biochemj.org | en_US |
dc.relation.ispartof | Biochemical Journal | en_US |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Amylases - Metabolism - Secretion | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Glucose - Metabolism | en_US |
dc.subject.mesh | Chymotrypsinogen - Metabolism - Secretion | en_US |
dc.subject.mesh | Insulin - Blood | en_US |
dc.subject.mesh | Lipase - Metabolism - Secretion | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Obesity - Enzymology | en_US |
dc.subject.mesh | Pancreas - Enzymology | en_US |
dc.subject.mesh | Proteins - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Zucker | en_US |
dc.title | Changes in content and secretion of pancreatic enzymes in the obese Zucker rat | en_US |
dc.type | Article | en_US |
dc.identifier.email | Bruzzone, R: bruzzone@hkucc.hku.hk | en_US |
dc.identifier.authority | Bruzzone, R=rp01442 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1042/bj2190333 | - |
dc.identifier.pmid | 6202297 | - |
dc.identifier.scopus | eid_2-s2.0-0021323779 | en_US |
dc.identifier.volume | 219 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 333 | en_US |
dc.identifier.epage | 336 | en_US |
dc.identifier.isi | WOS:A1984SL40200042 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Bruzzone, R=7006793327 | en_US |
dc.identifier.scopusauthorid | Trimble, ER=7005267920 | en_US |
dc.identifier.scopusauthorid | Gjinovci, A=6701391657 | en_US |
dc.identifier.scopusauthorid | Renold, AE=7005742513 | en_US |
dc.identifier.issnl | 0264-6021 | - |