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Article: Sigmoidity of the ventricular septum revisited: Progression in early adulthood, predominance in men, and independence from cardiac mass

TitleSigmoidity of the ventricular septum revisited: Progression in early adulthood, predominance in men, and independence from cardiac mass
Authors
Issue Date1988
Citation
American Journal Of Cardiovascular Pathology, 1988, v. 2 n. 3, p. 211-223 How to Cite?
AbstractMeager quantitative anatomic information is available regarding the orientation of the left ventricular outflow tract (LVOT) relative to the ventricular septum (VS), or the relation of these variables to patient age, sex, or other cardiac features. We studied 57 formaldehyde-fixed adult human heart specimens at autopsy from 29 men and 28 women ranging in age from 20 to 91 years (mean age = 66 years). Blinded measurement of 10 morphologic parameters, repeated on 2 occasions, included anatomic indexes of VS sigmoidity (angle between the aortic and the mitral plane). While sigmoidity was not correlated with patient height, body weight, body mass index, cardiac mss (or presence of systemic hypertension), cause of death, or VS length, it was significantly (p < 0.05) progressive through age groups 20-39 years, 40-59, 60-79 and ≥80. The overall correlation of aortic-mitral plane angle (A-MPA) with age was +0.59 (P < 0.0001), a relationship also noted within each age group. The mean A-MPA increased from 118 degrees to 127, 131 and 134 considering all specimens. Men had consistently greater sigmoidity than women. The steady increase in sigmoidity of the ventricular septum from early adulthood may alter clinical conclusions about pathologic conditions which are based upon septal curvature or prominence.
Persistent Identifierhttp://hdl.handle.net/10722/176007
ISSN

 

DC FieldValueLanguage
dc.contributor.authorToth, ABen_US
dc.contributor.authorEngel, JAen_US
dc.contributor.authorMcmanus, AMen_US
dc.contributor.authorMcmanus, BMen_US
dc.date.accessioned2012-11-26T09:04:30Z-
dc.date.available2012-11-26T09:04:30Z-
dc.date.issued1988en_US
dc.identifier.citationAmerican Journal Of Cardiovascular Pathology, 1988, v. 2 n. 3, p. 211-223en_US
dc.identifier.issn0887-8005en_US
dc.identifier.urihttp://hdl.handle.net/10722/176007-
dc.description.abstractMeager quantitative anatomic information is available regarding the orientation of the left ventricular outflow tract (LVOT) relative to the ventricular septum (VS), or the relation of these variables to patient age, sex, or other cardiac features. We studied 57 formaldehyde-fixed adult human heart specimens at autopsy from 29 men and 28 women ranging in age from 20 to 91 years (mean age = 66 years). Blinded measurement of 10 morphologic parameters, repeated on 2 occasions, included anatomic indexes of VS sigmoidity (angle between the aortic and the mitral plane). While sigmoidity was not correlated with patient height, body weight, body mass index, cardiac mss (or presence of systemic hypertension), cause of death, or VS length, it was significantly (p < 0.05) progressive through age groups 20-39 years, 40-59, 60-79 and ≥80. The overall correlation of aortic-mitral plane angle (A-MPA) with age was +0.59 (P < 0.0001), a relationship also noted within each age group. The mean A-MPA increased from 118 degrees to 127, 131 and 134 considering all specimens. Men had consistently greater sigmoidity than women. The steady increase in sigmoidity of the ventricular septum from early adulthood may alter clinical conclusions about pathologic conditions which are based upon septal curvature or prominence.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Cardiovascular Pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAging - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Septum - Anatomy & Histologyen_US
dc.subject.meshHeart Ventricles - Anatomy & Histologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSex Factorsen_US
dc.titleSigmoidity of the ventricular septum revisited: Progression in early adulthood, predominance in men, and independence from cardiac massen_US
dc.typeArticleen_US
dc.identifier.emailMcManus, AM: alimac@hku.hken_US
dc.identifier.authorityMcManus, AM=rp00936en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3219204-
dc.identifier.scopuseid_2-s2.0-0024212374en_US
dc.identifier.volume2en_US
dc.identifier.issue3en_US
dc.identifier.spage211en_US
dc.identifier.epage223en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridToth, AB=7202905038en_US
dc.identifier.scopusauthoridEngel, JA=35605746600en_US
dc.identifier.scopusauthoridMcManus, AM=7004635919en_US
dc.identifier.scopusauthoridMcManus, BM=7102867282en_US

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