File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

TitleGenome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Authors
Estrada, KStyrkarsdottir, UEvangelou, EHsu, YHDuncan, ELNtzani, EEOei, LAlbagha, OMEAmin, NKemp, JPKoller, DLLi, GLiu, CTMinster, RLMoayyeri, AVandenput, LWillner, DXiao, SMYergesArmstrong, LMZheng, HFAlonso, NEriksson, JKammerer, CMKaptoge, SKLeo, PJThorleifsson, GWilson, SGWilson, JFAalto, VAlen, MAragaki, AKAspelund, TCenter, JRDailiana, ZDuggan, DJGarcia, MGarciaGiralt, NGiroux, SHallmans, GHocking, LJHusted, LBJameson, KAKhusainova, RKim, GSKooperberg, CKoromila, TKruk, MLaaksonen, MLacroix, AZLee, SHLeung, PCLewis, JRMasi, LMencejBedrac, SNguyen, TVNogues, XPatel, MSPrezelj, JRose, LMScollen, SSiggeirsdottir, KSmith, AVSvensson, OTrompet, STrummer, OVan Schoor, NMWoo, JZhu, KBalcells, SBrandi, MLBuckley, BMCheng, SChristiansen, CCooper, CDedoussis, GFord, IFrost, MGoltzman, DGonzálezMacías, JKähönen, MKarlsson, MKhusnutdinova, EKoh, JMKollia, PLangdahl, BLLeslie, WDLips, PLjunggren, OLorenc, RSMarc, JMellström, DObermayerPietsch, BOlmos, JMPetterssonKymmer, UReid, DMRiancho, JARidker, PMRousseau, FLagboom, PESTang, NLSUrreizti, RVan Hul, WViikari, JZarrabeitia, MTAulchenko, YSCastanoBetancourt, MGrundberg, EHerrera, LIngvarsson, TJohannsdottir, HKwan, TLi, RLuben, RMedinaGómez, CTh Palsson, SReppe, SRotter, JISigurdsson, GVan Meurs, JBJVerlaan, DWilliams, FMKWood, ARZhou, YGautvik, KMPastinen, TRaychaudhuri, SCauley, JAChasman, DIClark, GRCummings, SRDanoy, PDennison, EMEastell, REisman, JAGudnason, VHofman, AJackson, RDJones, GJukema, JWKhaw, KTLehtimäki, TLiu, YLorentzon, MMccloskey, EMitchell, BDNandakumar, KNicholson, GCOostra, BAPeacock, MPols, HAPPrince, RLRaitakari, OReid, IRRobbins, JSambrook, PNSham, PCShuldiner, ARTylavsky, FAVan Duijn, CMWareham, NJCupples, LAEcons, MJEvans, DMHarris, TBKung, AWCPsaty, BMReeve, JSpector, TDStreeten, EAZillikens, MCThorsteinsdottir, UOhlsson, CKarasik, DRichards, JBBrown, MAStefansson, KUitterlinden, AGRalston, SHIoannidis, JPAKiel, DPRivadeneira, F
Issue Date2012
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2012, v. 44 n. 5, p. 491-501 How to Cite?
AbstractBone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10 -8). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10 -4, Bonferroni corrected), of which six reached P < 5 × 10 -8, including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. © 2012 Nature America, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175990
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEstrada, Ken_US
dc.contributor.authorStyrkarsdottir, Uen_US
dc.contributor.authorEvangelou, Een_US
dc.contributor.authorHsu, YHen_US
dc.contributor.authorDuncan, ELen_US
dc.contributor.authorNtzani, EEen_US
dc.contributor.authorOei, Len_US
dc.contributor.authorAlbagha, OMEen_US
dc.contributor.authorAmin, Nen_US
dc.contributor.authorKemp, JPen_US
dc.contributor.authorKoller, DLen_US
dc.contributor.authorLi, Gen_US
dc.contributor.authorLiu, CTen_US
dc.contributor.authorMinster, RLen_US
dc.contributor.authorMoayyeri, Aen_US
dc.contributor.authorVandenput, Len_US
dc.contributor.authorWillner, Den_US
dc.contributor.authorXiao, SMen_US
dc.contributor.authorYergesArmstrong, LMen_US
dc.contributor.authorZheng, HFen_US
dc.contributor.authorAlonso, Nen_US
dc.contributor.authorEriksson, Jen_US
dc.contributor.authorKammerer, CMen_US
dc.contributor.authorKaptoge, SKen_US
dc.contributor.authorLeo, PJen_US
dc.contributor.authorThorleifsson, Gen_US
dc.contributor.authorWilson, SGen_US
dc.contributor.authorWilson, JFen_US
dc.contributor.authorAalto, Ven_US
dc.contributor.authorAlen, Men_US
dc.contributor.authorAragaki, AKen_US
dc.contributor.authorAspelund, Ten_US
dc.contributor.authorCenter, JRen_US
dc.contributor.authorDailiana, Zen_US
dc.contributor.authorDuggan, DJen_US
dc.contributor.authorGarcia, Men_US
dc.contributor.authorGarciaGiralt, Nen_US
dc.contributor.authorGiroux, Sen_US
dc.contributor.authorHallmans, Gen_US
dc.contributor.authorHocking, LJen_US
dc.contributor.authorHusted, LBen_US
dc.contributor.authorJameson, KAen_US
dc.contributor.authorKhusainova, Ren_US
dc.contributor.authorKim, GSen_US
dc.contributor.authorKooperberg, Cen_US
dc.contributor.authorKoromila, Ten_US
dc.contributor.authorKruk, Men_US
dc.contributor.authorLaaksonen, Men_US
dc.contributor.authorLacroix, AZen_US
dc.contributor.authorLee, SHen_US
dc.contributor.authorLeung, PCen_US
dc.contributor.authorLewis, JRen_US
dc.contributor.authorMasi, Len_US
dc.contributor.authorMencejBedrac, Sen_US
dc.contributor.authorNguyen, TVen_US
dc.contributor.authorNogues, Xen_US
dc.contributor.authorPatel, MSen_US
dc.contributor.authorPrezelj, Jen_US
dc.contributor.authorRose, LMen_US
dc.contributor.authorScollen, Sen_US
dc.contributor.authorSiggeirsdottir, Ken_US
dc.contributor.authorSmith, AVen_US
dc.contributor.authorSvensson, Oen_US
dc.contributor.authorTrompet, Sen_US
dc.contributor.authorTrummer, Oen_US
dc.contributor.authorVan Schoor, NMen_US
dc.contributor.authorWoo, Jen_US
dc.contributor.authorZhu, Ken_US
dc.contributor.authorBalcells, Sen_US
dc.contributor.authorBrandi, MLen_US
dc.contributor.authorBuckley, BMen_US
dc.contributor.authorCheng, Sen_US
dc.contributor.authorChristiansen, Cen_US
dc.contributor.authorCooper, Cen_US
dc.contributor.authorDedoussis, Gen_US
dc.contributor.authorFord, Ien_US
dc.contributor.authorFrost, Men_US
dc.contributor.authorGoltzman, Den_US
dc.contributor.authorGonzálezMacías, Jen_US
dc.contributor.authorKähönen, Men_US
dc.contributor.authorKarlsson, Men_US
dc.contributor.authorKhusnutdinova, Een_US
dc.contributor.authorKoh, JMen_US
dc.contributor.authorKollia, Pen_US
dc.contributor.authorLangdahl, BLen_US
dc.contributor.authorLeslie, WDen_US
dc.contributor.authorLips, Pen_US
dc.contributor.authorLjunggren, Oen_US
dc.contributor.authorLorenc, RSen_US
dc.contributor.authorMarc, Jen_US
dc.contributor.authorMellström, Den_US
dc.contributor.authorObermayerPietsch, Ben_US
dc.contributor.authorOlmos, JMen_US
dc.contributor.authorPetterssonKymmer, Uen_US
dc.contributor.authorReid, DMen_US
dc.contributor.authorRiancho, JAen_US
dc.contributor.authorRidker, PMen_US
dc.contributor.authorRousseau, Fen_US
dc.contributor.authorLagboom, PESen_US
dc.contributor.authorTang, NLSen_US
dc.contributor.authorUrreizti, Ren_US
dc.contributor.authorVan Hul, Wen_US
dc.contributor.authorViikari, Jen_US
dc.contributor.authorZarrabeitia, MTen_US
dc.contributor.authorAulchenko, YSen_US
dc.contributor.authorCastanoBetancourt, Men_US
dc.contributor.authorGrundberg, Een_US
dc.contributor.authorHerrera, Len_US
dc.contributor.authorIngvarsson, Ten_US
dc.contributor.authorJohannsdottir, Hen_US
dc.contributor.authorKwan, Ten_US
dc.contributor.authorLi, Ren_US
dc.contributor.authorLuben, Ren_US
dc.contributor.authorMedinaGómez, Cen_US
dc.contributor.authorTh Palsson, Sen_US
dc.contributor.authorReppe, Sen_US
dc.contributor.authorRotter, JIen_US
dc.contributor.authorSigurdsson, Gen_US
dc.contributor.authorVan Meurs, JBJen_US
dc.contributor.authorVerlaan, Den_US
dc.contributor.authorWilliams, FMKen_US
dc.contributor.authorWood, ARen_US
dc.contributor.authorZhou, Yen_US
dc.contributor.authorGautvik, KMen_US
dc.contributor.authorPastinen, Ten_US
dc.contributor.authorRaychaudhuri, Sen_US
dc.contributor.authorCauley, JAen_US
dc.contributor.authorChasman, DIen_US
dc.contributor.authorClark, GRen_US
dc.contributor.authorCummings, SRen_US
dc.contributor.authorDanoy, Pen_US
dc.contributor.authorDennison, EMen_US
dc.contributor.authorEastell, Ren_US
dc.contributor.authorEisman, JAen_US
dc.contributor.authorGudnason, Ven_US
dc.contributor.authorHofman, Aen_US
dc.contributor.authorJackson, RDen_US
dc.contributor.authorJones, Gen_US
dc.contributor.authorJukema, JWen_US
dc.contributor.authorKhaw, KTen_US
dc.contributor.authorLehtimäki, Ten_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorLorentzon, Men_US
dc.contributor.authorMccloskey, Een_US
dc.contributor.authorMitchell, BDen_US
dc.contributor.authorNandakumar, Ken_US
dc.contributor.authorNicholson, GCen_US
dc.contributor.authorOostra, BAen_US
dc.contributor.authorPeacock, Men_US
dc.contributor.authorPols, HAPen_US
dc.contributor.authorPrince, RLen_US
dc.contributor.authorRaitakari, Oen_US
dc.contributor.authorReid, IRen_US
dc.contributor.authorRobbins, Jen_US
dc.contributor.authorSambrook, PNen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorShuldiner, ARen_US
dc.contributor.authorTylavsky, FAen_US
dc.contributor.authorVan Duijn, CMen_US
dc.contributor.authorWareham, NJen_US
dc.contributor.authorCupples, LAen_US
dc.contributor.authorEcons, MJen_US
dc.contributor.authorEvans, DMen_US
dc.contributor.authorHarris, TBen_US
dc.contributor.authorKung, AWCen_US
dc.contributor.authorPsaty, BMen_US
dc.contributor.authorReeve, Jen_US
dc.contributor.authorSpector, TDen_US
dc.contributor.authorStreeten, EAen_US
dc.contributor.authorZillikens, MCen_US
dc.contributor.authorThorsteinsdottir, Uen_US
dc.contributor.authorOhlsson, Cen_US
dc.contributor.authorKarasik, Den_US
dc.contributor.authorRichards, JBen_US
dc.contributor.authorBrown, MAen_US
dc.contributor.authorStefansson, Ken_US
dc.contributor.authorUitterlinden, AGen_US
dc.contributor.authorRalston, SHen_US
dc.contributor.authorIoannidis, JPAen_US
dc.contributor.authorKiel, DPen_US
dc.contributor.authorRivadeneira, Fen_US
dc.date.accessioned2012-11-26T09:03:31Z-
dc.date.available2012-11-26T09:03:31Z-
dc.date.issued2012en_US
dc.identifier.citationNature Genetics, 2012, v. 44 n. 5, p. 491-501en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/175990-
dc.description.abstractBone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10 -8). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10 -4, Bonferroni corrected), of which six reached P < 5 × 10 -8, including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility. © 2012 Nature America, Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_US
dc.relation.ispartofNature Geneticsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshComputational Biologyen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshExtracellular Matrix Proteins - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFemur Neck - Physiopathologyen_US
dc.subject.meshFractures, Bone - Geneticsen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenome-Wide Association Studyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGlycoproteins - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntercellular Signaling Peptides And Proteins - Geneticsen_US
dc.subject.meshLow Density Lipoprotein Receptor-Related Protein-5 - Geneticsen_US
dc.subject.meshLumbar Vertebrae - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMitochondrial Membrane Transport Proteins - Geneticsen_US
dc.subject.meshOsteoporosis - Geneticsen_US
dc.subject.meshPhosphoproteins - Geneticsen_US
dc.subject.meshPolymorphism, Single Nucleotide - Geneticsen_US
dc.subject.meshQuantitative Trait Locien_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSpectrin - Geneticsen_US
dc.titleGenome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fractureen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ng.2249en_US
dc.identifier.pmid22504420-
dc.identifier.scopuseid_2-s2.0-84860331458en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860331458&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume44en_US
dc.identifier.issue5en_US
dc.identifier.spage491en_US
dc.identifier.epage501en_US
dc.identifier.isiWOS:000303416300007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridEstrada, K=25824883500en_US
dc.identifier.scopusauthoridStyrkarsdottir, U=12761328700en_US
dc.identifier.scopusauthoridEvangelou, E=22957065200en_US
dc.identifier.scopusauthoridHsu, YH=8071612400en_US
dc.identifier.scopusauthoridDuncan, EL=7006067588en_US
dc.identifier.scopusauthoridNtzani, EE=6506421672en_US
dc.identifier.scopusauthoridOei, L=54080149100en_US
dc.identifier.scopusauthoridAlbagha, OME=6507876500en_US
dc.identifier.scopusauthoridAmin, N=24329223700en_US
dc.identifier.scopusauthoridKemp, JP=36993915500en_US
dc.identifier.scopusauthoridKoller, DL=35399194400en_US
dc.identifier.scopusauthoridLi, G=24174650200en_US
dc.identifier.scopusauthoridLiu, CT=24329885600en_US
dc.identifier.scopusauthoridMinster, RL=6506888764en_US
dc.identifier.scopusauthoridMoayyeri, A=6508210074en_US
dc.identifier.scopusauthoridVandenput, L=8782798800en_US
dc.identifier.scopusauthoridWillner, D=55372061300en_US
dc.identifier.scopusauthoridXiao, SM=55179174600en_US
dc.identifier.scopusauthoridYergesArmstrong, LM=35103784600en_US
dc.identifier.scopusauthoridZheng, HF=25960539800en_US
dc.identifier.scopusauthoridAlonso, N=36150489700en_US
dc.identifier.scopusauthoridEriksson, J=38661349700en_US
dc.identifier.scopusauthoridKammerer, CM=7005441706en_US
dc.identifier.scopusauthoridKaptoge, SK=6602645217en_US
dc.identifier.scopusauthoridLeo, PJ=24391045800en_US
dc.identifier.scopusauthoridThorleifsson, G=7003411255en_US
dc.identifier.scopusauthoridWilson, SG=35428868100en_US
dc.identifier.scopusauthoridWilson, JF=35273994800en_US
dc.identifier.scopusauthoridAalto, V=53881112400en_US
dc.identifier.scopusauthoridAlen, M=7003433840en_US
dc.identifier.scopusauthoridAragaki, AK=6602563694en_US
dc.identifier.scopusauthoridAspelund, T=8703984700en_US
dc.identifier.scopusauthoridCenter, JR=7004173206en_US
dc.identifier.scopusauthoridDailiana, Z=6701809109en_US
dc.identifier.scopusauthoridDuggan, DJ=44060967100en_US
dc.identifier.scopusauthoridGarcia, M=7404278124en_US
dc.identifier.scopusauthoridGarciaGiralt, N=6508313021en_US
dc.identifier.scopusauthoridGiroux, S=55236124200en_US
dc.identifier.scopusauthoridHallmans, G=7006749585en_US
dc.identifier.scopusauthoridHocking, LJ=7003673083en_US
dc.identifier.scopusauthoridHusted, LB=6602255791en_US
dc.identifier.scopusauthoridJameson, KA=18134339100en_US
dc.identifier.scopusauthoridKhusainova, R=6602798130en_US
dc.identifier.scopusauthoridKim, GS=55098539800en_US
dc.identifier.scopusauthoridKooperberg, C=26643152600en_US
dc.identifier.scopusauthoridKoromila, T=50262280600en_US
dc.identifier.scopusauthoridKruk, M=13204775100en_US
dc.identifier.scopusauthoridLaaksonen, M=24390934700en_US
dc.identifier.scopusauthoridLacroix, AZ=26643429600en_US
dc.identifier.scopusauthoridLee, SH=55095841100en_US
dc.identifier.scopusauthoridLeung, PC=55200404600en_US
dc.identifier.scopusauthoridLewis, JR=36490037800en_US
dc.identifier.scopusauthoridMasi, L=7004365273en_US
dc.identifier.scopusauthoridMencejBedrac, S=26433809100en_US
dc.identifier.scopusauthoridNguyen, TV=7404371483en_US
dc.identifier.scopusauthoridNogues, X=7004515486en_US
dc.identifier.scopusauthoridPatel, MS=7403721377en_US
dc.identifier.scopusauthoridPrezelj, J=7004264031en_US
dc.identifier.scopusauthoridRose, LM=35604277600en_US
dc.identifier.scopusauthoridScollen, S=7801641421en_US
dc.identifier.scopusauthoridSiggeirsdottir, K=6506006248en_US
dc.identifier.scopusauthoridSmith, AV=7406753503en_US
dc.identifier.scopusauthoridSvensson, O=7006824856en_US
dc.identifier.scopusauthoridTrompet, S=22954837300en_US
dc.identifier.scopusauthoridTrummer, O=15074496700en_US
dc.identifier.scopusauthoridVan Schoor, NM=35380634200en_US
dc.identifier.scopusauthoridWoo, J=55060426700en_US
dc.identifier.scopusauthoridZhu, K=25652258600en_US
dc.identifier.scopusauthoridBalcells, S=6603887741en_US
dc.identifier.scopusauthoridBrandi, ML=7102461515en_US
dc.identifier.scopusauthoridBuckley, BM=7102038929en_US
dc.identifier.scopusauthoridCheng, S=7404684535en_US
dc.identifier.scopusauthoridChristiansen, C=36040368300en_US
dc.identifier.scopusauthoridCooper, C=36041345700en_US
dc.identifier.scopusauthoridDedoussis, G=6701705920en_US
dc.identifier.scopusauthoridFord, I=7006691891en_US
dc.identifier.scopusauthoridFrost, M=36069143900en_US
dc.identifier.scopusauthoridGoltzman, D=55004747200en_US
dc.identifier.scopusauthoridGonzálezMacías, J=55121232600en_US
dc.identifier.scopusauthoridKähönen, M=55163527600en_US
dc.identifier.scopusauthoridKarlsson, M=16178166100en_US
dc.identifier.scopusauthoridKhusnutdinova, E=35381528600en_US
dc.identifier.scopusauthoridKoh, JM=35239980600en_US
dc.identifier.scopusauthoridKollia, P=6603679586en_US
dc.identifier.scopusauthoridLangdahl, BL=35229491800en_US
dc.identifier.scopusauthoridLeslie, WD=35434221900en_US
dc.identifier.scopusauthoridLips, P=34570960500en_US
dc.identifier.scopusauthoridLjunggren, O=7005243956en_US
dc.identifier.scopusauthoridLorenc, RS=7005713798en_US
dc.identifier.scopusauthoridMarc, J=7006701288en_US
dc.identifier.scopusauthoridMellström, D=24174880900en_US
dc.identifier.scopusauthoridObermayerPietsch, B=55150157800en_US
dc.identifier.scopusauthoridOlmos, JM=7006049629en_US
dc.identifier.scopusauthoridPetterssonKymmer, U=55179389900en_US
dc.identifier.scopusauthoridReid, DM=35372429900en_US
dc.identifier.scopusauthoridRiancho, JA=7005073770en_US
dc.identifier.scopusauthoridRidker, PM=36039269800en_US
dc.identifier.scopusauthoridRousseau, F=7102890389en_US
dc.identifier.scopusauthoridLagboom, PES=55200774900en_US
dc.identifier.scopusauthoridTang, NLS=7202344588en_US
dc.identifier.scopusauthoridUrreizti, R=6507495208en_US
dc.identifier.scopusauthoridVan Hul, W=7006357757en_US
dc.identifier.scopusauthoridViikari, J=35446128700en_US
dc.identifier.scopusauthoridZarrabeitia, MT=7004208162en_US
dc.identifier.scopusauthoridAulchenko, YS=6603626351en_US
dc.identifier.scopusauthoridCastanoBetancourt, M=36622125400en_US
dc.identifier.scopusauthoridGrundberg, E=6506067746en_US
dc.identifier.scopusauthoridHerrera, L=55178980900en_US
dc.identifier.scopusauthoridIngvarsson, T=6701749645en_US
dc.identifier.scopusauthoridJohannsdottir, H=55400174500en_US
dc.identifier.scopusauthoridKwan, T=35337205100en_US
dc.identifier.scopusauthoridLi, R=37026545400en_US
dc.identifier.scopusauthoridLuben, R=7004585179en_US
dc.identifier.scopusauthoridMedinaGómez, C=55179389000en_US
dc.identifier.scopusauthoridTh Palsson, S=55179389100en_US
dc.identifier.scopusauthoridReppe, S=6602876606en_US
dc.identifier.scopusauthoridRotter, JI=7103219677en_US
dc.identifier.scopusauthoridSigurdsson, G=7005332253en_US
dc.identifier.scopusauthoridVan Meurs, JBJ=7005539448en_US
dc.identifier.scopusauthoridVerlaan, D=6506762624en_US
dc.identifier.scopusauthoridWilliams, FMK=8059345500en_US
dc.identifier.scopusauthoridWood, AR=36505189800en_US
dc.identifier.scopusauthoridZhou, Y=23053503600en_US
dc.identifier.scopusauthoridGautvik, KM=7004961263en_US
dc.identifier.scopusauthoridPastinen, T=6601992219en_US
dc.identifier.scopusauthoridRaychaudhuri, S=7006375923en_US
dc.identifier.scopusauthoridCauley, JA=35373878900en_US
dc.identifier.scopusauthoridChasman, DI=6701612213en_US
dc.identifier.scopusauthoridClark, GR=36628039400en_US
dc.identifier.scopusauthoridCummings, SR=35373488900en_US
dc.identifier.scopusauthoridDanoy, P=13004316200en_US
dc.identifier.scopusauthoridDennison, EM=26643483300en_US
dc.identifier.scopusauthoridEastell, R=55172320900en_US
dc.identifier.scopusauthoridEisman, JA=7101944285en_US
dc.identifier.scopusauthoridGudnason, V=7003353432en_US
dc.identifier.scopusauthoridHofman, A=36048731400en_US
dc.identifier.scopusauthoridJackson, RD=7404310087en_US
dc.identifier.scopusauthoridJones, G=34769726500en_US
dc.identifier.scopusauthoridJukema, JW=7005836769en_US
dc.identifier.scopusauthoridKhaw, KT=55096753500en_US
dc.identifier.scopusauthoridLehtimäki, T=7006539182en_US
dc.identifier.scopusauthoridLiu, Y=35435449700en_US
dc.identifier.scopusauthoridLorentzon, M=7003987830en_US
dc.identifier.scopusauthoridMccloskey, E=7004852037en_US
dc.identifier.scopusauthoridMitchell, BD=7401949811en_US
dc.identifier.scopusauthoridNandakumar, K=53981905100en_US
dc.identifier.scopusauthoridNicholson, GC=7202311794en_US
dc.identifier.scopusauthoridOostra, BA=7102229127en_US
dc.identifier.scopusauthoridPeacock, M=7101801281en_US
dc.identifier.scopusauthoridPols, HAP=35374891300en_US
dc.identifier.scopusauthoridPrince, RL=25651986100en_US
dc.identifier.scopusauthoridRaitakari, O=7004828916en_US
dc.identifier.scopusauthoridReid, IR=24475157600en_US
dc.identifier.scopusauthoridRobbins, J=35227861600en_US
dc.identifier.scopusauthoridSambrook, PN=7103142193en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridShuldiner, AR=35374955600en_US
dc.identifier.scopusauthoridTylavsky, FA=35406372300en_US
dc.identifier.scopusauthoridVan Duijn, CM=36037246700en_US
dc.identifier.scopusauthoridWareham, NJ=34668706300en_US
dc.identifier.scopusauthoridCupples, LA=7007090535en_US
dc.identifier.scopusauthoridEcons, MJ=7006283956en_US
dc.identifier.scopusauthoridEvans, DM=7601571931en_US
dc.identifier.scopusauthoridHarris, TB=35375662400en_US
dc.identifier.scopusauthoridKung, AWC=55087119000en_US
dc.identifier.scopusauthoridPsaty, BM=35374213400en_US
dc.identifier.scopusauthoridReeve, J=7202242451en_US
dc.identifier.scopusauthoridSpector, TD=35351391300en_US
dc.identifier.scopusauthoridStreeten, EA=6601987607en_US
dc.identifier.scopusauthoridZillikens, MC=6602743474en_US
dc.identifier.scopusauthoridThorsteinsdottir, U=6602988969en_US
dc.identifier.scopusauthoridOhlsson, C=7006582588en_US
dc.identifier.scopusauthoridKarasik, D=7004384589en_US
dc.identifier.scopusauthoridRichards, JB=14051143300en_US
dc.identifier.scopusauthoridBrown, MA=7405388484en_US
dc.identifier.scopusauthoridStefansson, K=7005997553en_US
dc.identifier.scopusauthoridUitterlinden, AG=35231615000en_US
dc.identifier.scopusauthoridRalston, SH=36511708000en_US
dc.identifier.scopusauthoridIoannidis, JPA=35377033000en_US
dc.identifier.scopusauthoridKiel, DP=7005526959en_US
dc.identifier.scopusauthoridRivadeneira, F=7801419664en_US
dc.identifier.citeulike10572141-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats