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Article: A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings

TitleA family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings
Authors
KeywordsEndophenotypes
Neuropsychology
Psychosis
Social Cognition
Issue Date2011
PublisherScience China Press. The Journal's web site is located at http://www.springerlink.com/content/1001-6538/
Citation
Chinese Science Bulletin, 2011, v. 56 n. 32, p. 3394-3397 How to Cite?
AbstractThe study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. © 2011 Science China Press and Springer-Verlag Berlin Heidelberg.
Persistent Identifierhttp://hdl.handle.net/10722/175988
ISSN
2015 Impact Factor: 1.789
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLui, SSYen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorChan, RCKen_US
dc.contributor.authorCheung, EFCen_US
dc.date.accessioned2012-11-26T09:03:19Z-
dc.date.available2012-11-26T09:03:19Z-
dc.date.issued2011en_US
dc.identifier.citationChinese Science Bulletin, 2011, v. 56 n. 32, p. 3394-3397en_US
dc.identifier.issn1001-6538en_US
dc.identifier.urihttp://hdl.handle.net/10722/175988-
dc.description.abstractThe study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. © 2011 Science China Press and Springer-Verlag Berlin Heidelberg.en_US
dc.languageengen_US
dc.publisherScience China Press. The Journal's web site is located at http://www.springerlink.com/content/1001-6538/en_US
dc.relation.ispartofChinese Science Bulletinen_US
dc.subjectEndophenotypesen_US
dc.subjectNeuropsychologyen_US
dc.subjectPsychosisen_US
dc.subjectSocial Cognitionen_US
dc.titleA family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findingsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11434-011-4734-2en_US
dc.identifier.scopuseid_2-s2.0-80355133289en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80355133289&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue32en_US
dc.identifier.spage3394en_US
dc.identifier.epage3397en_US
dc.identifier.isiWOS:000296641800007-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLui, SSY=35292835200en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridChan, RCK=35725165500en_US
dc.identifier.scopusauthoridCheung, EFC=7006522469en_US
dc.identifier.citeulike9761231-

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