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Article: A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia

TitleA controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
Authors
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2004, v. 56 n. 6, p. 454-461 How to Cite?
AbstractWe examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities. Magnetic resonance imaging brain scans were obtained from 14 monozygotic twin pairs concordant and 10 monozygotic pairs discordant for schizophrenia, as well as 17 pairs of monozygotic control twins. Twenty-two discordant sibling-pairs and 56 pairs of unrelated control subjects were included to assess the extent of genetic control over these structures. Within-pair similarities for whole brain volume increased as pair members were more closely related genetically (monozygotic twins > siblings > unrelated control subjects). Schizophrenic twins, whether from concordant or discordant pairs, had smaller whole brain volumes than control twins. The probands of discordant pairs showed more abnormalities in hippocampal, third and lateral ventricular volumes than concordant twins. Whole brain volume is under high genetic control and smaller whole brain volume is a reflection of the genetic liability to develop schizophrenia. The variation in hippocampal and ventricular volumes within discordant monozygotic pairs indicates a role for environmental factors in determining these volume abnormalities in schizophrenia. Such factors may also underlie the more extensive morphometric deviations in patients from monozygotic discordant twins than in their counterparts from concordant twins.
Persistent Identifierhttp://hdl.handle.net/10722/175970
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVan Haren, NEMen_US
dc.contributor.authorPicchioni, MMen_US
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorMarshall, Nen_US
dc.contributor.authorDavis, Nen_US
dc.contributor.authorRibchester, Ten_US
dc.contributor.authorHulshoff Pol, HEen_US
dc.contributor.authorSharma, Ten_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKahn, RSen_US
dc.contributor.authorMurray, Ren_US
dc.date.accessioned2012-11-26T09:03:07Z-
dc.date.available2012-11-26T09:03:07Z-
dc.date.issued2004en_US
dc.identifier.citationBiological Psychiatry, 2004, v. 56 n. 6, p. 454-461en_US
dc.identifier.issn0006-3223en_US
dc.identifier.urihttp://hdl.handle.net/10722/175970-
dc.description.abstractWe examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities. Magnetic resonance imaging brain scans were obtained from 14 monozygotic twin pairs concordant and 10 monozygotic pairs discordant for schizophrenia, as well as 17 pairs of monozygotic control twins. Twenty-two discordant sibling-pairs and 56 pairs of unrelated control subjects were included to assess the extent of genetic control over these structures. Within-pair similarities for whole brain volume increased as pair members were more closely related genetically (monozygotic twins > siblings > unrelated control subjects). Schizophrenic twins, whether from concordant or discordant pairs, had smaller whole brain volumes than control twins. The probands of discordant pairs showed more abnormalities in hippocampal, third and lateral ventricular volumes than concordant twins. Whole brain volume is under high genetic control and smaller whole brain volume is a reflection of the genetic liability to develop schizophrenia. The variation in hippocampal and ventricular volumes within discordant monozygotic pairs indicates a role for environmental factors in determining these volume abnormalities in schizophrenia. Such factors may also underlie the more extensive morphometric deviations in patients from monozygotic discordant twins than in their counterparts from concordant twins.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_US
dc.relation.ispartofBiological Psychiatryen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshBrain - Pathologyen_US
dc.subject.meshDiseases In Twins - Diagnosis - Epidemiology - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHippocampus - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisted - Methodsen_US
dc.subject.meshLateral Ventricles - Pathologyen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSchizophrenia - Epidemiology - Genetics - Pathologyen_US
dc.subject.meshSiblingsen_US
dc.subject.meshThird Ventricle - Pathologyen_US
dc.subject.meshTwins, Monozygoticen_US
dc.titleA controlled study of brain structure in monozygotic twins concordant and discordant for schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biopsych.2004.06.033en_US
dc.identifier.pmid15364044-
dc.identifier.scopuseid_2-s2.0-4444246518en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444246518&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue6en_US
dc.identifier.spage454en_US
dc.identifier.epage461en_US
dc.identifier.isiWOS:000223855200011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVan Haren, NEM=6603501057en_US
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_US
dc.identifier.scopusauthoridMcDonald, C=8749594800en_US
dc.identifier.scopusauthoridMarshall, N=7102431159en_US
dc.identifier.scopusauthoridDavis, N=7202358705en_US
dc.identifier.scopusauthoridRibchester, T=55405730800en_US
dc.identifier.scopusauthoridHulshoff Pol, HE=6603905466en_US
dc.identifier.scopusauthoridSharma, T=7202571892en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKahn, RS=7201463706en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US

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