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Article: Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives

TitleNeurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2007, v. 144B n. 4, p. 407-416 How to Cite?
AbstractSome neuropsychological abilities, particularly those affecting memory, attention and executive function, are impaired amongst both schizophrenic patients and their unaffected relatives, implying that these deficits are at least partly genetic in origin. However neuropsychological performance can be altered by medication, and has rarely been examined in first onset, drug naive patients. The objective of this study was to determine whether selected neurocognitive abilities are impaired in first-onset schizophrenic patients and their relatives compared to controls. We examined attention and speed of information processing, memory and learning, verbal function, visuoconstructive abilities and executive function in 207 first-episode schizophrenic patients (163 of whom were drug naïve), 322 of their first-degree relatives and 133 unrelated normal controls. The data were subjected to multilevel modeling to compare neurocognitive performance between schizophrenic probands, relatives and controls while taking into account potential correlations among members of the same family; age, gender, and years of education were included as covariates. Of the three groups, schizophrenic patients performed poorest at all neuropsychological tests, suggestive of a broad range of neurocognitive deficits. Their first-degree relatives showed a narrower pattern of poor performance at Digit Symbol, Digit Span, Trail Making, Verbal Fluency test, Tower of Hanoi, and WCST-M tests. Our findings show that selected neurocognitive deficits especially attention and executive function are impaired in the families of schizophrenic patients. These patterns of neurocognitive deficits may represent "endophenotypes" denoting varying degrees of vulnerability to schizophrenia and may be of value in future molecular genetic studies. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/175967
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, Xen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorRabe-Hesketh, Sen_US
dc.contributor.authorSun, Xen_US
dc.contributor.authorHu, Jen_US
dc.contributor.authorMeng, Hen_US
dc.contributor.authorChen, Wen_US
dc.contributor.authorChen, EYHen_US
dc.contributor.authorDeng, Wen_US
dc.contributor.authorChan, RCKen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorLi, Ten_US
dc.date.accessioned2012-11-26T09:03:04Z-
dc.date.available2012-11-26T09:03:04Z-
dc.date.issued2007en_US
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2007, v. 144B n. 4, p. 407-416en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175967-
dc.description.abstractSome neuropsychological abilities, particularly those affecting memory, attention and executive function, are impaired amongst both schizophrenic patients and their unaffected relatives, implying that these deficits are at least partly genetic in origin. However neuropsychological performance can be altered by medication, and has rarely been examined in first onset, drug naive patients. The objective of this study was to determine whether selected neurocognitive abilities are impaired in first-onset schizophrenic patients and their relatives compared to controls. We examined attention and speed of information processing, memory and learning, verbal function, visuoconstructive abilities and executive function in 207 first-episode schizophrenic patients (163 of whom were drug naïve), 322 of their first-degree relatives and 133 unrelated normal controls. The data were subjected to multilevel modeling to compare neurocognitive performance between schizophrenic probands, relatives and controls while taking into account potential correlations among members of the same family; age, gender, and years of education were included as covariates. Of the three groups, schizophrenic patients performed poorest at all neuropsychological tests, suggestive of a broad range of neurocognitive deficits. Their first-degree relatives showed a narrower pattern of poor performance at Digit Symbol, Digit Span, Trail Making, Verbal Fluency test, Tower of Hanoi, and WCST-M tests. Our findings show that selected neurocognitive deficits especially attention and executive function are impaired in the families of schizophrenic patients. These patterns of neurocognitive deficits may represent "endophenotypes" denoting varying degrees of vulnerability to schizophrenia and may be of value in future molecular genetic studies. © 2007 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Distributionen_US
dc.subject.meshAgeden_US
dc.subject.meshAttentionen_US
dc.subject.meshCognitionen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshDemographyen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMemoryen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeuropsychological Testsen_US
dc.subject.meshSchizophrenia - Physiopathologyen_US
dc.subject.meshSex Distributionen_US
dc.subject.meshVerbal Behavioren_US
dc.titleNeurocognitive deficits in first-episode schizophrenic patients and their first-degree relativesen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.emailChen, EYH: eyhchen@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.identifier.authorityChen, EYH=rp00392en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30330en_US
dc.identifier.pmid17440937-
dc.identifier.scopuseid_2-s2.0-34250859540en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250859540&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume144Ben_US
dc.identifier.issue4en_US
dc.identifier.spage407en_US
dc.identifier.epage416en_US
dc.identifier.isiWOS:000246982700002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMa, X=35354066000en_US
dc.identifier.scopusauthoridWang, Q=7406916913en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridRabeHesketh, S=7003779088en_US
dc.identifier.scopusauthoridSun, X=7405624871en_US
dc.identifier.scopusauthoridHu, J=14054355600en_US
dc.identifier.scopusauthoridMeng, H=9133658800en_US
dc.identifier.scopusauthoridChen, W=35975528400en_US
dc.identifier.scopusauthoridChen, EYH=7402315729en_US
dc.identifier.scopusauthoridDeng, W=7202222559en_US
dc.identifier.scopusauthoridChan, RCK=35236280300en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.customcontrol.immutablesml 140918-

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