File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.

TitleA note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.
Authors
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244
Citation
Behavior Genetics, 2006, v. 36 n. 6, p. 947-950 How to Cite?
AbstractTransmission distortion refers to deviation from the normal 50:50 transmission of alleles from parents to offspring. Identification of genomic regions which undergo distortion is necessary for the correct interpretation of linkage and association studies, since tests of linkage using affected relative pairs and family based tests of association will yield spurious results in the presence of transmission distortion. With the increasing availability of genome-wide high density SNP data (e.g. from the International HapMap project), identification of these loci is now a real possibility. Here we present an analytical formula which demonstrates that the power to detect transmission distortion is a simple function of the number of heterozygous parents in the sample and the level of distortion at the locus. Our results indicate that whilst it will be possible to identify loci undergoing major levels of distortion using tens or hundreds of trios, large sample sizes in the order of tens of thousands of trios will be necessary to detect minor levels of distortion with appreciable power. The corollary is that genome-wide searches are unlikely to identify loci where the level of distortion is small, although they may serve to identify interesting regions worthy of follow up.
Persistent Identifierhttp://hdl.handle.net/10722/175965
ISSN
2015 Impact Factor: 3.268
2015 SCImago Journal Rankings: 1.457
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorEvans, DMen_US
dc.contributor.authorMorris, APen_US
dc.contributor.authorCardon, LRen_US
dc.contributor.authorSham, PCen_US
dc.date.accessioned2012-11-26T09:03:03Z-
dc.date.available2012-11-26T09:03:03Z-
dc.date.issued2006en_US
dc.identifier.citationBehavior Genetics, 2006, v. 36 n. 6, p. 947-950en_US
dc.identifier.issn0001-8244en_US
dc.identifier.urihttp://hdl.handle.net/10722/175965-
dc.description.abstractTransmission distortion refers to deviation from the normal 50:50 transmission of alleles from parents to offspring. Identification of genomic regions which undergo distortion is necessary for the correct interpretation of linkage and association studies, since tests of linkage using affected relative pairs and family based tests of association will yield spurious results in the presence of transmission distortion. With the increasing availability of genome-wide high density SNP data (e.g. from the International HapMap project), identification of these loci is now a real possibility. Here we present an analytical formula which demonstrates that the power to detect transmission distortion is a simple function of the number of heterozygous parents in the sample and the level of distortion at the locus. Our results indicate that whilst it will be possible to identify loci undergoing major levels of distortion using tens or hundreds of trios, large sample sizes in the order of tens of thousands of trios will be necessary to detect minor levels of distortion with appreciable power. The corollary is that genome-wide searches are unlikely to identify loci where the level of distortion is small, although they may serve to identify interesting regions worthy of follow up.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244en_US
dc.relation.ispartofBehavior geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibrium - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshParent-Child Relationsen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshTwins - Geneticsen_US
dc.titleA note on the power to detect transmission distortion in parent-child trios via the transmission disequilibrium test.en_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10519-006-9087-2en_US
dc.identifier.pmid16804748-
dc.identifier.scopuseid_2-s2.0-34250317899en_US
dc.identifier.volume36en_US
dc.identifier.issue6en_US
dc.identifier.spage947en_US
dc.identifier.epage950en_US
dc.identifier.isiWOS:000249448900013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridEvans, DM=7601571931en_US
dc.identifier.scopusauthoridMorris, AP=7403404824en_US
dc.identifier.scopusauthoridCardon, LR=7005082964en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.citeulike762602-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats