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Article: Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia

TitleLinkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia
Authors
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
Neuroscience Research, 2007, v. 57 n. 2, p. 194-202 How to Cite?
AbstractSeveral previous studies have reported a significant linkage between markers in the alpha 7 nicotinic cholinergic receptor subunit (CHRNA7) gene and either schizophrenia or the P50 sensory gating deficit, a schizophrenia endophenotype. However, CHRFAM7A, a partially duplicated gene 1.6 Mb upstream of the CHRNA7 gene, has complicated further genetic analysis. We genotyped 14 polymorphic markers throughout the full-length CHRNA7 gene and the duplicated region in 188 unrelated Han Chinese patients with schizophrenia and 188 controls. The duplicated regions were assessed by genotyping up- and down-stream polymorphic markers in the vicinity of each region and analyzing the linkage disequilibrium (LD) between each pair of markers. No evidence of risk variants for schizophrenia in either the CHRNA7 gene or the partially duplicated region was found in the LD analysis. A significant deviation from the Hardy-Weinberg equilibrium (HWE) was found only in the genotypic distribution of SNP9 (IVS4-1912) in patients (p = 0.00829), but not in controls. In conclusion, our LD analysis did not reveal any association between schizophrenia in our Han Chinese population and the CHRNA7 gene or its partially duplicated region. However, we could not exclude the possibility of a weak genetic effect due to the small sample size. Analyses of larger samples and higher-density markers, particularly around SNP9 (IVS4-1912), are still needed. © 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society.
Persistent Identifierhttp://hdl.handle.net/10722/175963
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIwata, Yen_US
dc.contributor.authorNakajima, Men_US
dc.contributor.authorYamada, Ken_US
dc.contributor.authorNakamura, Ken_US
dc.contributor.authorSekine, Yen_US
dc.contributor.authorTsuchiya, KJen_US
dc.contributor.authorSugihara, Gen_US
dc.contributor.authorMatsuzaki, Hen_US
dc.contributor.authorSuda, Sen_US
dc.contributor.authorSuzuki, Ken_US
dc.contributor.authorTakei, Nen_US
dc.contributor.authorMori, Nen_US
dc.contributor.authorIwayama, Yen_US
dc.contributor.authorTakao, Hen_US
dc.contributor.authorYoshikawa, Ten_US
dc.contributor.authorRiley, Ben_US
dc.contributor.authorMakoff, Aen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorChen, Ren_US
dc.contributor.authorCollier, Den_US
dc.date.accessioned2012-11-26T09:03:02Z-
dc.date.available2012-11-26T09:03:02Z-
dc.date.issued2007en_US
dc.identifier.citationNeuroscience Research, 2007, v. 57 n. 2, p. 194-202en_US
dc.identifier.issn0168-0102en_US
dc.identifier.urihttp://hdl.handle.net/10722/175963-
dc.description.abstractSeveral previous studies have reported a significant linkage between markers in the alpha 7 nicotinic cholinergic receptor subunit (CHRNA7) gene and either schizophrenia or the P50 sensory gating deficit, a schizophrenia endophenotype. However, CHRFAM7A, a partially duplicated gene 1.6 Mb upstream of the CHRNA7 gene, has complicated further genetic analysis. We genotyped 14 polymorphic markers throughout the full-length CHRNA7 gene and the duplicated region in 188 unrelated Han Chinese patients with schizophrenia and 188 controls. The duplicated regions were assessed by genotyping up- and down-stream polymorphic markers in the vicinity of each region and analyzing the linkage disequilibrium (LD) between each pair of markers. No evidence of risk variants for schizophrenia in either the CHRNA7 gene or the partially duplicated region was found in the LD analysis. A significant deviation from the Hardy-Weinberg equilibrium (HWE) was found only in the genotypic distribution of SNP9 (IVS4-1912) in patients (p = 0.00829), but not in controls. In conclusion, our LD analysis did not reveal any association between schizophrenia in our Han Chinese population and the CHRNA7 gene or its partially duplicated region. However, we could not exclude the possibility of a weak genetic effect due to the small sample size. Analyses of larger samples and higher-density markers, particularly around SNP9 (IVS4-1912), are still needed. © 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuresen_US
dc.relation.ispartofNeuroscience Researchen_US
dc.rightsNeuroscience Research. Copyright © Elsevier Ireland Ltd.-
dc.subject.meshAsian Continental Ancestry Group - Ethnologyen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Nicotinic - Geneticsen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.titleLinkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neures.2006.10.002en_US
dc.identifier.pmid17113175-
dc.identifier.scopuseid_2-s2.0-33846685488en_US
dc.identifier.hkuros133090-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846685488&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume57en_US
dc.identifier.issue2en_US
dc.identifier.spage194en_US
dc.identifier.epage202en_US
dc.identifier.isiWOS:000244575200004-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridIwata, Y=7202730104en_US
dc.identifier.scopusauthoridNakajima, M=15754128900en_US
dc.identifier.scopusauthoridYamada, K=7405389843en_US
dc.identifier.scopusauthoridNakamura, K=7406773797en_US
dc.identifier.scopusauthoridSekine, Y=7201681655en_US
dc.identifier.scopusauthoridTsuchiya, KJ=8567495200en_US
dc.identifier.scopusauthoridSugihara, G=14036448600en_US
dc.identifier.scopusauthoridMatsuzaki, H=7202461913en_US
dc.identifier.scopusauthoridSuda, S=15046113400en_US
dc.identifier.scopusauthoridSuzuki, K=7501778438en_US
dc.identifier.scopusauthoridTakei, N=7102701392en_US
dc.identifier.scopusauthoridMori, N=7402512072en_US
dc.identifier.scopusauthoridIwayama, Y=8720196000en_US
dc.identifier.scopusauthoridTakao, H=8683253900en_US
dc.identifier.scopusauthoridYoshikawa, T=7402717943en_US
dc.identifier.scopusauthoridRiley, B=7004434002en_US
dc.identifier.scopusauthoridMakoff, A=7006063526en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridChen, R=16635066600en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US

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