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Article: Heritability and reliability of P300, P50 and duration mismatch negativity.

TitleHeritability and reliability of P300, P50 and duration mismatch negativity.
Authors
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244
Citation
Behavior Genetics, 2006, v. 36 n. 6, p. 845-857 How to Cite?
AbstractBACKGROUND: Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs. METHODS: ERP components (P300, P50 and MMN) were recorded using a 19-channel electroencephalogram (EEG) in 40 healthy monozygotic twin pairs, 19 of them on two separate occasions, and 30 dizygotic twin pairs. Zygosity was determined using DNA genotyping. RESULTS: High reliabilities were found for the P300 amplitude and its latency, MMN amplitude, and P50 suppression ratio components. ICC=0.86 and 0.88 for the P300 amplitude and P300 latency respectively. Reliability of MMN peak amplitude and mean amplitude were 0.67 and 0.66 respectively. P50 T/C ratio reliability was 0.66. Model fitting analyses indicated a substantial heritability or familial component of variance for these ERP measures. Heritability estimates were 63 and 68% for MMN peak amplitude and mean amplitude respectively. For P50 T/C ratio, 68% heritability was estimated. P300 amplitude heritability was estimated at 69%, and while a significant familiality effect was found for P300 latency there was insufficient power to distinguish between shared environment and genetic factors. CONCLUSIONS: The high reliability and heritability of the P300 amplitude, MMN amplitude, and P50 suppression ratio components supports their use as candidate endophenotypes for psychiatric research.
Persistent Identifierhttp://hdl.handle.net/10722/175962
ISSN
2015 Impact Factor: 3.268
2015 SCImago Journal Rankings: 1.457
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHall, MHen_US
dc.contributor.authorSchulze, Ken_US
dc.contributor.authorRijsdijk, Fen_US
dc.contributor.authorPicchioni, Men_US
dc.contributor.authorEttinger, Uen_US
dc.contributor.authorBramon, Een_US
dc.contributor.authorFreedman, Ren_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorSham, Pen_US
dc.date.accessioned2012-11-26T09:03:01Z-
dc.date.available2012-11-26T09:03:01Z-
dc.date.issued2006en_US
dc.identifier.citationBehavior Genetics, 2006, v. 36 n. 6, p. 845-857en_US
dc.identifier.issn0001-8244en_US
dc.identifier.urihttp://hdl.handle.net/10722/175962-
dc.description.abstractBACKGROUND: Event-related potentials (ERPs) have been suggested as possible endophenotypes of schizophrenia. We investigated the test-retest reliabilities and heritabilities of three ERP components in healthy monozygotic and dizygotic twin pairs. METHODS: ERP components (P300, P50 and MMN) were recorded using a 19-channel electroencephalogram (EEG) in 40 healthy monozygotic twin pairs, 19 of them on two separate occasions, and 30 dizygotic twin pairs. Zygosity was determined using DNA genotyping. RESULTS: High reliabilities were found for the P300 amplitude and its latency, MMN amplitude, and P50 suppression ratio components. ICC=0.86 and 0.88 for the P300 amplitude and P300 latency respectively. Reliability of MMN peak amplitude and mean amplitude were 0.67 and 0.66 respectively. P50 T/C ratio reliability was 0.66. Model fitting analyses indicated a substantial heritability or familial component of variance for these ERP measures. Heritability estimates were 63 and 68% for MMN peak amplitude and mean amplitude respectively. For P50 T/C ratio, 68% heritability was estimated. P300 amplitude heritability was estimated at 69%, and while a significant familiality effect was found for P300 latency there was insufficient power to distinguish between shared environment and genetic factors. CONCLUSIONS: The high reliability and heritability of the P300 amplitude, MMN amplitude, and P50 suppression ratio components supports their use as candidate endophenotypes for psychiatric research.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244en_US
dc.relation.ispartofBehavior geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshEvoked Potentials - Geneticsen_US
dc.subject.meshEye Movements - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshLondonen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshRegistriesen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshTwins, Dizygoticen_US
dc.subject.meshTwins, Monozygoticen_US
dc.titleHeritability and reliability of P300, P50 and duration mismatch negativity.en_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10519-006-9091-6en_US
dc.identifier.pmid16826459-
dc.identifier.scopuseid_2-s2.0-33845877343en_US
dc.identifier.volume36en_US
dc.identifier.issue6en_US
dc.identifier.spage845en_US
dc.identifier.epage857en_US
dc.identifier.isiWOS:000249448900005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHall, MH=14013171900en_US
dc.identifier.scopusauthoridSchulze, K=7103137549en_US
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_US
dc.identifier.scopusauthoridPicchioni, M=6507443795en_US
dc.identifier.scopusauthoridEttinger, U=6602766172en_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridFreedman, R=7202526906en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.citeulike949832-

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