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Article: Candidate transmission disequilibrium analysis for quantitative traits in tourette syndrome in a chinese family trio sample

TitleCandidate transmission disequilibrium analysis for quantitative traits in tourette syndrome in a chinese family trio sample
Authors
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 4, p. 524 How to Cite?
AbstractTourette's syndrome is a complex and heritable behavioral disorder with early onset (2-15 years), prominently characterized by motor and vocal ticks affecting up to 1/100 boys and 1/700 girls. Several neurotransmitter receptor pathways and related biosynthetic enzymes have been implicated in its etiology through previous genetic and/or biological analysis. Using genotypes from functional polymorphisms in the catechol-O-methyltransferase gene COMT (Val158Met), dopamine D4 receptor gene DRD4 (exon III VNTR and a promoter SNP), dopamine D2 receptor gene DRD2 (promoter SNP), monoamine oxidase A MAOA (promoter CA repeat sequence) and serotonin receptor gene HTR2A (promoter SNP), we performed association analysis using the Quantitative Transmission Disequilibrium approach with scores for the Conners, CBCL and Depression scale for the affected children and three QTD Tests proposed by Abecasis et al., Rabinowitz et al., and Allison et al. Significant associations (<0.05) were found between the 5-HTR2A gene and the traits 'delinquent' (p=0.0147, 66 probands), 'thought' (p=0.0417, 66 probands) and 'extrovert' (p=0.0347, 66 probands); COMT gene with the "compulsive" trait (p=0.0458, 69 probands); and DRD4 VNTR with the 'bad behavior' trait (p=0.048). Using the method proposed by Fulker et al. (1999) a test for population stratification was performed on all trios and no significant evidence for population stratification was found. Therefore, an overall test for association was performed (i.e. not a TDT). Significant associations (0.01) were found between the DRD2 promoter and the traits 'depression mood' (p=0.01, 94 probands), 'low confidence' (p=0.002); DRD4 VNTR and traits 'bad behavior' (p < 0.001, 95 probands), 'group activity' (p=0.008, 95 probands); MAO polymorphism and traits 'bad behavior' (p=0.007, 38 probands), 'somatic' (p=0.0046, 56 probands), 'aggressive' (p<0.001, 56 probands), 'extrovert' (p<0.001, 56 probands).
Persistent Identifierhttp://hdl.handle.net/10722/175960
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorJawaid, Aen_US
dc.contributor.authorHuang, Yen_US
dc.contributor.authorLi, Ten_US
dc.contributor.authorHu, Xen_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorGuo, Len_US
dc.contributor.authorMa, Xen_US
dc.contributor.authorLiu, Jen_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorCollier, Den_US
dc.contributor.authorSham, Pen_US
dc.date.accessioned2012-11-26T09:02:55Z-
dc.date.available2012-11-26T09:02:55Z-
dc.date.issued2000en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 4, p. 524en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175960-
dc.description.abstractTourette's syndrome is a complex and heritable behavioral disorder with early onset (2-15 years), prominently characterized by motor and vocal ticks affecting up to 1/100 boys and 1/700 girls. Several neurotransmitter receptor pathways and related biosynthetic enzymes have been implicated in its etiology through previous genetic and/or biological analysis. Using genotypes from functional polymorphisms in the catechol-O-methyltransferase gene COMT (Val158Met), dopamine D4 receptor gene DRD4 (exon III VNTR and a promoter SNP), dopamine D2 receptor gene DRD2 (promoter SNP), monoamine oxidase A MAOA (promoter CA repeat sequence) and serotonin receptor gene HTR2A (promoter SNP), we performed association analysis using the Quantitative Transmission Disequilibrium approach with scores for the Conners, CBCL and Depression scale for the affected children and three QTD Tests proposed by Abecasis et al., Rabinowitz et al., and Allison et al. Significant associations (<0.05) were found between the 5-HTR2A gene and the traits 'delinquent' (p=0.0147, 66 probands), 'thought' (p=0.0417, 66 probands) and 'extrovert' (p=0.0347, 66 probands); COMT gene with the "compulsive" trait (p=0.0458, 69 probands); and DRD4 VNTR with the 'bad behavior' trait (p=0.048). Using the method proposed by Fulker et al. (1999) a test for population stratification was performed on all trios and no significant evidence for population stratification was found. Therefore, an overall test for association was performed (i.e. not a TDT). Significant associations (0.01) were found between the DRD2 promoter and the traits 'depression mood' (p=0.01, 94 probands), 'low confidence' (p=0.002); DRD4 VNTR and traits 'bad behavior' (p < 0.001, 95 probands), 'group activity' (p=0.008, 95 probands); MAO polymorphism and traits 'bad behavior' (p=0.007, 38 probands), 'somatic' (p=0.0046, 56 probands), 'aggressive' (p<0.001, 56 probands), 'extrovert' (p<0.001, 56 probands).en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleCandidate transmission disequilibrium analysis for quantitative traits in tourette syndrome in a chinese family trio sampleen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749112707en_US
dc.identifier.volume96en_US
dc.identifier.issue4en_US
dc.identifier.spage524en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJawaid, A=12787441800en_US
dc.identifier.scopusauthoridHuang, Y=23977949200en_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridHu, X=7404710558en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridGuo, L=7403156762en_US
dc.identifier.scopusauthoridMa, X=35354066000en_US
dc.identifier.scopusauthoridLiu, J=27170630300en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US

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