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Article: Evidence of genomic imprinting in families with Gilles de la Tourette Syndrome in Chinese subjects

TitleEvidence of genomic imprinting in families with Gilles de la Tourette Syndrome in Chinese subjects
Authors
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2001, v. 105 n. 7, p. 587-588 How to Cite?
AbstractPrevious attempts using large multigenerational families to localize susceptibility loci of Gilles de la Tourette Syndrome (GTS) have been unsuccessful ,which primarily due to the complex mode of its inheritance. Recently, several studies reported that genomic imprinting may be involved in the transmission of GTS in caucasion population.In this study, a semi-structured schedule for the genetic research of Tourette syndrome and related disorders was used in the family study of genomic imprinting in 171 probands with GTS. The family data include information from 342 first degree relatives, 1283 second degree relatives and 2310 third degree relatives in addition to probands. Our data suggest that maternal transmission was associated with the symptom of complex motor tics in the proband; P = 0.01. Maternal transmission was more likely to present earlier-onset of the disease than paternal transmission 5.56 + 0.85 Yr; 6.07+1.10 Yr; t = 2.34; P = 0.02. However, paternal transmitted GTS was characterized by the increased attention problem score in CBCL behavioral scale of the proband t = 2.78; P = 0.01. This result indicated that parental specific expression exists in the transmission of GTS, which gives evidence that genomic imprinting may be involved in the inheritance of GTS in Chinese people.
Persistent Identifierhttp://hdl.handle.net/10722/175959
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorHuang, Yen_US
dc.contributor.authorLi, Ten_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorGuo, Len_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:02:54Z-
dc.date.available2012-11-26T09:02:54Z-
dc.date.issued2001en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2001, v. 105 n. 7, p. 587-588en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175959-
dc.description.abstractPrevious attempts using large multigenerational families to localize susceptibility loci of Gilles de la Tourette Syndrome (GTS) have been unsuccessful ,which primarily due to the complex mode of its inheritance. Recently, several studies reported that genomic imprinting may be involved in the transmission of GTS in caucasion population.In this study, a semi-structured schedule for the genetic research of Tourette syndrome and related disorders was used in the family study of genomic imprinting in 171 probands with GTS. The family data include information from 342 first degree relatives, 1283 second degree relatives and 2310 third degree relatives in addition to probands. Our data suggest that maternal transmission was associated with the symptom of complex motor tics in the proband; P = 0.01. Maternal transmission was more likely to present earlier-onset of the disease than paternal transmission 5.56 + 0.85 Yr; 6.07+1.10 Yr; t = 2.34; P = 0.02. However, paternal transmitted GTS was characterized by the increased attention problem score in CBCL behavioral scale of the proband t = 2.78; P = 0.01. This result indicated that parental specific expression exists in the transmission of GTS, which gives evidence that genomic imprinting may be involved in the inheritance of GTS in Chinese people.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleEvidence of genomic imprinting in families with Gilles de la Tourette Syndrome in Chinese subjectsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749112278en_US
dc.identifier.volume105en_US
dc.identifier.issue7en_US
dc.identifier.spage587en_US
dc.identifier.epage588en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHuang, Y=35596180300en_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridGuo, L=7403156762en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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