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Article: A twin study of clinical variables in psychotic disorders

TitleA twin study of clinical variables in psychotic disorders
Authors
Issue Date2000
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 4, p. 503-504 How to Cite?
AbstractBackground: Psychotic disorders show considerable clinical heterogeneity. However, little is known about the genetic basis of most clinical variables. Methods: 224 proband-wise twin pairs (106 MZ, 118 same-sex DZ) where probands had a lifetime history of psychosis were ascertained from the Maudsley Hospital Twin Register in London. Familial aggregation for a range of subtypes, symptoms, illness history and comorbidity variables was investigated in twin pairs concordant for RDC psychotic disorders. Relationships between clinical variables and genetic liability to psychoses, as measured by risk of psychoses in co-twins, were assessed using logistic regression analysis. Results: Familial aggregation was greater in MZ than DZ pairs and/ or previous sib-pair studies for age of onset; hebephrenic vs other subtypes of schizophrenia; inappropriate affect, and positive formal thought disorder; and for illness course, life-time marital status and premorbid social adjustment in schizophrenia and all psychoses combined (and delusions of influence and catatonia in schizophrenia). There was a modest relationship between familial liability to psychoses and younger age of illness onset; positive formal thought disorder, and catatonia; and poor premorbid social adjust-ment and never marrying. Conclusions: On the basis of this and previous studies there is strong evidence for a genetic contribution to age of onset in psychotic disorders, and some evidence of a genetic contribution to other clinically relevant variables.
Persistent Identifierhttp://hdl.handle.net/10722/175954
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorCardno, Aen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorMurray, Pen_US
dc.contributor.authorMcguffin, Pen_US
dc.date.accessioned2012-11-26T09:02:51Z-
dc.date.available2012-11-26T09:02:51Z-
dc.date.issued2000en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2000, v. 96 n. 4, p. 503-504en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175954-
dc.description.abstractBackground: Psychotic disorders show considerable clinical heterogeneity. However, little is known about the genetic basis of most clinical variables. Methods: 224 proband-wise twin pairs (106 MZ, 118 same-sex DZ) where probands had a lifetime history of psychosis were ascertained from the Maudsley Hospital Twin Register in London. Familial aggregation for a range of subtypes, symptoms, illness history and comorbidity variables was investigated in twin pairs concordant for RDC psychotic disorders. Relationships between clinical variables and genetic liability to psychoses, as measured by risk of psychoses in co-twins, were assessed using logistic regression analysis. Results: Familial aggregation was greater in MZ than DZ pairs and/ or previous sib-pair studies for age of onset; hebephrenic vs other subtypes of schizophrenia; inappropriate affect, and positive formal thought disorder; and for illness course, life-time marital status and premorbid social adjustment in schizophrenia and all psychoses combined (and delusions of influence and catatonia in schizophrenia). There was a modest relationship between familial liability to psychoses and younger age of illness onset; positive formal thought disorder, and catatonia; and poor premorbid social adjust-ment and never marrying. Conclusions: On the basis of this and previous studies there is strong evidence for a genetic contribution to age of onset in psychotic disorders, and some evidence of a genetic contribution to other clinically relevant variables.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleA twin study of clinical variables in psychotic disordersen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749090811en_US
dc.identifier.volume96en_US
dc.identifier.issue4en_US
dc.identifier.spage503en_US
dc.identifier.epage504en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCardno, A=7004499892en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridMurray, P=14634422500en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US

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