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Article: Further evidence of transmission disequilibrium of the catechol-O-methyl transferase (COMT) gene in schizophrenia in a Chinese population

TitleFurther evidence of transmission disequilibrium of the catechol-O-methyl transferase (COMT) gene in schizophrenia in a Chinese population
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1998, v. 81 n. 6, p. 515 How to Cite?
AbstractSeveral lines of evidence pointed to a locus for psychosis near the COMT gene on chromosome 22q11. We previously reported linkage disequilibrium between Chinese schizophrenic subjects and a Val158Met polymorphism in exon 4 of the COMT gene [Li et al., 1996]. We have now genotyped an additional four biallelic polymorphic markers (promoter/Hind III, exon 3/Pml I, exon 4/Bcl I, and exon 6/Bgl I) in 200 family trios, consisting of Han Chinese schizophrenic subjects and their parents. These five polymorphic markers (including of Val158Met) were in strong linkage disequilibrium with each other (P value from 0.0001 to 0) except between exon 4/Bcl I and exon6/Bgl I (P = 0.77). The data were analysed using the transmission disequilibrium test (TDT) for individual polymorphism markers and haplotypes between paired markers. We found evidence of linkage disequilibrium for one polymorphism alone in exon 3/Pml I (P = 0.02, two tailed), but others were not significant. When we used haplotype of pairs of markers for TDT analysis (ETDT2 program, David Curtis and Pak Sham), the results gave much stronger evidence of linkage disequilibrium between the COMT gene and schizophrenia. Seven haplotypes out of ten analysed and gave P value less than 0.05 (from 0.0006 to 0.036 for allele-wise). P values were 0.0006 for allele-wise and 0.004 for genotype-wise when using haplotype of Val158Met and exon 6/Bgl I for TDT analysis. Our results support the hypothesis that COMT is a susceptibility gene, or this region of chromosome 22 contains a susceptibility gene which is in linkage disequilibrium with the COMT gene.
Persistent Identifierhttp://hdl.handle.net/10722/175953
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:02:51Z-
dc.date.available2012-11-26T09:02:51Z-
dc.date.issued1998en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1998, v. 81 n. 6, p. 515en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175953-
dc.description.abstractSeveral lines of evidence pointed to a locus for psychosis near the COMT gene on chromosome 22q11. We previously reported linkage disequilibrium between Chinese schizophrenic subjects and a Val158Met polymorphism in exon 4 of the COMT gene [Li et al., 1996]. We have now genotyped an additional four biallelic polymorphic markers (promoter/Hind III, exon 3/Pml I, exon 4/Bcl I, and exon 6/Bgl I) in 200 family trios, consisting of Han Chinese schizophrenic subjects and their parents. These five polymorphic markers (including of Val158Met) were in strong linkage disequilibrium with each other (P value from 0.0001 to 0) except between exon 4/Bcl I and exon6/Bgl I (P = 0.77). The data were analysed using the transmission disequilibrium test (TDT) for individual polymorphism markers and haplotypes between paired markers. We found evidence of linkage disequilibrium for one polymorphism alone in exon 3/Pml I (P = 0.02, two tailed), but others were not significant. When we used haplotype of pairs of markers for TDT analysis (ETDT2 program, David Curtis and Pak Sham), the results gave much stronger evidence of linkage disequilibrium between the COMT gene and schizophrenia. Seven haplotypes out of ten analysed and gave P value less than 0.05 (from 0.0006 to 0.036 for allele-wise). P values were 0.0006 for allele-wise and 0.004 for genotype-wise when using haplotype of Val158Met and exon 6/Bgl I for TDT analysis. Our results support the hypothesis that COMT is a susceptibility gene, or this region of chromosome 22 contains a susceptibility gene which is in linkage disequilibrium with the COMT gene.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleFurther evidence of transmission disequilibrium of the catechol-O-methyl transferase (COMT) gene in schizophrenia in a Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749087494en_US
dc.identifier.volume81en_US
dc.identifier.issue6en_US
dc.identifier.spage515en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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