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Article: Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population

TitleEvidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2004, v. 129 B n. 1, p. 13-15 How to Cite?
AbstractHaploinsufficiency for or mutation in at least one gene from the velocardiofacial syndrome (VCFS) region at chromosome 22q11 is implicated in psychosis. Linkage disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al., 2002a] and by analysis of additional polymorphisms the PRODH gene was associated with schizophrenia in adult and early onset patients. In the present study we provide additional evidence in support of genetic association between PRODH and schizophrenia in a Chinese population. We analyzed the PRODH gene in a samples of schizophrenic patients and their families from Sichuan, SW China consisting of 528 family trios and sibling pairs. We genotyped six SNPs, PRODH* 1195C→T, PRODH* 1482C→T, PRODH*1483A→G, PRODH* 1766A→G, PRODH*1852G→A PRODH*1945T→C, two of which (PRODH*1483A→G and PRODH* 1852G→A) have not been previously reported. We found association with schizophrenia for two haplotypes consisting of PRODH*1945T→C and PRODH*1852G→A (Global P=0.006), and PRODH*1852G→A and PRODH*1766A→G (Global P = 0.01) which include one of the newly identified markers. After six-fold Bonferroni correction for multiple testing the PRODH*1945T-C/PRODH*1852G-A haplotypes remained significant. This is a sub-haplotype of the PRODH haplotype previously associated with schizophrenia and it also maps to the 3′ region of the gene, indicating that this is the region most likely to contain the underlying risk alleles. Overall this finding supports a role for the PRODH locus in schizophrenia. © 2004 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/175949
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorMa, Xen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorSun, Xen_US
dc.contributor.authorHu, Xen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorMeng, Hen_US
dc.contributor.authorDeng, Wen_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:02:49Z-
dc.date.available2012-11-26T09:02:49Z-
dc.date.issued2004en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2004, v. 129 B n. 1, p. 13-15en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175949-
dc.description.abstractHaploinsufficiency for or mutation in at least one gene from the velocardiofacial syndrome (VCFS) region at chromosome 22q11 is implicated in psychosis. Linkage disequilibrium mapping of the region in patients identified a segment containing two genes, proline dehydrogenase (PRODH) and DGCR6, as candidates [Liu et al., 2002a] and by analysis of additional polymorphisms the PRODH gene was associated with schizophrenia in adult and early onset patients. In the present study we provide additional evidence in support of genetic association between PRODH and schizophrenia in a Chinese population. We analyzed the PRODH gene in a samples of schizophrenic patients and their families from Sichuan, SW China consisting of 528 family trios and sibling pairs. We genotyped six SNPs, PRODH* 1195C→T, PRODH* 1482C→T, PRODH*1483A→G, PRODH* 1766A→G, PRODH*1852G→A PRODH*1945T→C, two of which (PRODH*1483A→G and PRODH* 1852G→A) have not been previously reported. We found association with schizophrenia for two haplotypes consisting of PRODH*1945T→C and PRODH*1852G→A (Global P=0.006), and PRODH*1852G→A and PRODH*1766A→G (Global P = 0.01) which include one of the newly identified markers. After six-fold Bonferroni correction for multiple testing the PRODH*1945T-C/PRODH*1852G-A haplotypes remained significant. This is a sub-haplotype of the PRODH haplotype previously associated with schizophrenia and it also maps to the 3′ region of the gene, indicating that this is the region most likely to contain the underlying risk alleles. Overall this finding supports a role for the PRODH locus in schizophrenia. © 2004 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshChinaen_US
dc.subject.meshFamily Healthen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshPedigreeen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshProline Oxidase - Geneticsen_US
dc.subject.meshSchizophrenia - Enzymology - Geneticsen_US
dc.subject.meshSiblingsen_US
dc.titleEvidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30049-
dc.identifier.pmid15274030-
dc.identifier.scopuseid_2-s2.0-3343019031en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3343019031&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume129 Ben_US
dc.identifier.issue1en_US
dc.identifier.spage13en_US
dc.identifier.epage15en_US
dc.identifier.isiWOS:000222975700003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridMa, X=35354066000en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridSun, X=7405624871en_US
dc.identifier.scopusauthoridHu, X=7404709241en_US
dc.identifier.scopusauthoridWang, Q=7406916913en_US
dc.identifier.scopusauthoridMeng, H=9133658800en_US
dc.identifier.scopusauthoridDeng, W=7202222559en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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