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Article: Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis

TitleMorbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis
Authors
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 136 B n. 1, p. 87-91 How to Cite?
AbstractIt is not clear why some methamphetamine (MAMP) abusers develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We tested the hypotheses that those users who develop MAMP-induced psychosis (MIP) have greater familial loading for psychotic disorders than users with no psychosis. Four hundred forty-five MAMP users were recruited from a psychiatric hospital and a detention center in Taipei, and were assessed with the Diagnostic Interview for genetic studies (DIGS-C) and the Family Interview for genetic study (FIGS-C). Morbid risk (MR) for psychiatric disorders in first-degree relatives was compared between those MAMP users with a lifetime diagnosis of MAMP psychosis and those without. The relatives of MAMP users with a lifetime diagnosis of MAMP psychosis had a significantly higher MR for schizophrenia (OR = 5.4, 95% CI: 2.0-14.7, P < 0.001) than the relatives of those probands who never became psychotic. Furthermore, the MR for schizophrenia in the relatives of the subjects with a prolonged MAMP psychosis (MIP-P) was higher than in the relatives of those users with a brief MAMP psychosis (MIP-B) (OR = 2.8, 95% CI: 1.0-8.0, P = 0.042). The greater his or her familial loading for schizophrenia, the more likely a MAMP user is to develop psychosis, and the longer that psychosis is likely to last. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/175932
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, CKen_US
dc.contributor.authorLin, SKen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorBall, Den_US
dc.contributor.authorLoh, EWen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:02:37Z-
dc.date.available2012-11-26T09:02:37Z-
dc.date.issued2005en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 136 B n. 1, p. 87-91en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175932-
dc.description.abstractIt is not clear why some methamphetamine (MAMP) abusers develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We tested the hypotheses that those users who develop MAMP-induced psychosis (MIP) have greater familial loading for psychotic disorders than users with no psychosis. Four hundred forty-five MAMP users were recruited from a psychiatric hospital and a detention center in Taipei, and were assessed with the Diagnostic Interview for genetic studies (DIGS-C) and the Family Interview for genetic study (FIGS-C). Morbid risk (MR) for psychiatric disorders in first-degree relatives was compared between those MAMP users with a lifetime diagnosis of MAMP psychosis and those without. The relatives of MAMP users with a lifetime diagnosis of MAMP psychosis had a significantly higher MR for schizophrenia (OR = 5.4, 95% CI: 2.0-14.7, P < 0.001) than the relatives of those probands who never became psychotic. Furthermore, the MR for schizophrenia in the relatives of the subjects with a prolonged MAMP psychosis (MIP-P) was higher than in the relatives of those users with a brief MAMP psychosis (MIP-B) (OR = 2.8, 95% CI: 1.0-8.0, P = 0.042). The greater his or her familial loading for schizophrenia, the more likely a MAMP user is to develop psychosis, and the longer that psychosis is likely to last. © 2005 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAmphetamine-Related Disorders - Epidemiology - Geneticsen_US
dc.subject.meshComorbidityen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInterviews As Topicen_US
dc.subject.meshMaleen_US
dc.subject.meshMental Disorders - Geneticsen_US
dc.subject.meshMethamphetamine - Poisoningen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshPsychotic Disorders - Epidemiology - Etiologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Epidemiology - Geneticsen_US
dc.titleMorbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosisen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30187en_US
dc.identifier.pmid15892150-
dc.identifier.scopuseid_2-s2.0-21444451423en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21444451423&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume136 Ben_US
dc.identifier.issue1en_US
dc.identifier.spage87en_US
dc.identifier.epage91en_US
dc.identifier.isiWOS:000230052700015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, CK=7501961684en_US
dc.identifier.scopusauthoridLin, SK=7407607751en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridBall, D=7202703810en_US
dc.identifier.scopusauthoridLoh, EW=7102994165en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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