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Article: Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: Computational morphometry study

TitleRegional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: Computational morphometry study
Authors
Issue Date2005
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 2005, v. 186 MAY, p. 369-377 How to Cite?
AbstractBackground: It is unclear whether schizophrenia and psychotic bipolar disorder are associated with similar deviations of brain morphometry. Aims: To assess volumetric abnormalities of grey and white matter throughout the entire brain in individuals with schizophrenia or with bipolar disorder compared with the same control group. Method: Brain scans were obtained by magnetic resonance imaging from 25 people with schizophrenia, 37 with bipolar disorder who had experienced psychotic symptoms and 52 healthy volunteers. Regional deviation in grey and white matter volume was assessed using computational morphometry. Results: Individuals with schizophrenia had distributed grey matter deficit predominantly involving the fronto-temporal neocortex, medial temporal lobe, insula, thalamus and cerebellum, whereas those with bipolar disorder had no significant regions of grey matter abnormality. Both groups had anatomically overlapping white matter deficits in regions normally occupied by major longitudinal and interhemispheric tracts. Conclusions: Schizophrenia and psychotic bipolar disorder are associated with distinct grey matter deficits but anatomically coincident white matter abnormalities.
Persistent Identifierhttp://hdl.handle.net/10722/175927
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorBullmore, Een_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorChitnis, Xen_US
dc.contributor.authorSuckling, Jen_US
dc.contributor.authorMaccabe, Jen_US
dc.contributor.authorWalshe, Men_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:02:34Z-
dc.date.available2012-11-26T09:02:34Z-
dc.date.issued2005en_US
dc.identifier.citationBritish Journal Of Psychiatry, 2005, v. 186 MAY, p. 369-377en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175927-
dc.description.abstractBackground: It is unclear whether schizophrenia and psychotic bipolar disorder are associated with similar deviations of brain morphometry. Aims: To assess volumetric abnormalities of grey and white matter throughout the entire brain in individuals with schizophrenia or with bipolar disorder compared with the same control group. Method: Brain scans were obtained by magnetic resonance imaging from 25 people with schizophrenia, 37 with bipolar disorder who had experienced psychotic symptoms and 52 healthy volunteers. Regional deviation in grey and white matter volume was assessed using computational morphometry. Results: Individuals with schizophrenia had distributed grey matter deficit predominantly involving the fronto-temporal neocortex, medial temporal lobe, insula, thalamus and cerebellum, whereas those with bipolar disorder had no significant regions of grey matter abnormality. Both groups had anatomically overlapping white matter deficits in regions normally occupied by major longitudinal and interhemispheric tracts. Conclusions: Schizophrenia and psychotic bipolar disorder are associated with distinct grey matter deficits but anatomically coincident white matter abnormalities.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBipolar Disorder - Pathologyen_US
dc.subject.meshBrain - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSchizophrenia - Pathologyen_US
dc.titleRegional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: Computational morphometry studyen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.186.5.369en_US
dc.identifier.pmid15863740-
dc.identifier.scopuseid_2-s2.0-18644367817en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18644367817&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume186en_US
dc.identifier.issueMAYen_US
dc.identifier.spage369en_US
dc.identifier.epage377en_US
dc.identifier.isiWOS:000228911200004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMcDonald, C=8749594800en_US
dc.identifier.scopusauthoridBullmore, E=35405771500en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridChitnis, X=6602314186en_US
dc.identifier.scopusauthoridSuckling, J=7004124496en_US
dc.identifier.scopusauthoridMacCabe, J=7003607616en_US
dc.identifier.scopusauthoridWalshe, M=8855469300en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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