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- Publisher Website: 10.1159/000083030
- Scopus: eid_2-s2.0-18444396148
- PMID: 15711089
- WOS: WOS:000226979500005
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Article: Properties of structured association approaches to detecting population stratification
Title | Properties of structured association approaches to detecting population stratification |
---|---|
Authors | |
Keywords | Genomic control Lateral class analysis Linkage disequilibrium Population stratification Structured association |
Issue Date | 2004 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/HHE |
Citation | Human Heredity, 2004, v. 58 n. 2, p. 93-107 How to Cite? |
Abstract | Objective: To examine the properties of the structured association approach for the detection and correction of population stratification. Method: A method is developed, within a latent class analysis framework, similar to the methods proposed by Satten et al. (2001) and Pritchard et al. (2000). A series of simulations illustrate the relative impact of number and type of loci, sample size and population structure. Results: The ability to detect stratification and assign individuals to population strata is determined for a number of different scenarios. Conclusion: The results underline the importance of careful marker selection. Copyright © 2004 S. Karger AG. |
Persistent Identifier | http://hdl.handle.net/10722/175926 |
ISSN | 2023 Impact Factor: 1.1 2023 SCImago Journal Rankings: 0.483 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Purcell, S | en_US |
dc.contributor.author | Sham, P | en_US |
dc.date.accessioned | 2012-11-26T09:02:34Z | - |
dc.date.available | 2012-11-26T09:02:34Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Human Heredity, 2004, v. 58 n. 2, p. 93-107 | en_US |
dc.identifier.issn | 0001-5652 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175926 | - |
dc.description.abstract | Objective: To examine the properties of the structured association approach for the detection and correction of population stratification. Method: A method is developed, within a latent class analysis framework, similar to the methods proposed by Satten et al. (2001) and Pritchard et al. (2000). A series of simulations illustrate the relative impact of number and type of loci, sample size and population structure. Results: The ability to detect stratification and assign individuals to population strata is determined for a number of different scenarios. Conclusion: The results underline the importance of careful marker selection. Copyright © 2004 S. Karger AG. | en_US |
dc.language | eng | en_US |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/HHE | en_US |
dc.relation.ispartof | Human Heredity | en_US |
dc.subject | Genomic control | - |
dc.subject | Lateral class analysis | - |
dc.subject | Linkage disequilibrium | - |
dc.subject | Population stratification | - |
dc.subject | Structured association | - |
dc.subject.mesh | Algorithms | en_US |
dc.subject.mesh | Computer Simulation | en_US |
dc.subject.mesh | Data Interpretation, Statistical | en_US |
dc.subject.mesh | Gene Frequency | en_US |
dc.subject.mesh | Genetics, Population - Statistics & Numerical Data | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Linkage Disequilibrium | en_US |
dc.title | Properties of structured association approaches to detecting population stratification | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, P: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, P=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1159/000083030 | en_US |
dc.identifier.pmid | 15711089 | - |
dc.identifier.scopus | eid_2-s2.0-18444396148 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-18444396148&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 93 | en_US |
dc.identifier.epage | 107 | en_US |
dc.identifier.isi | WOS:000226979500005 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Purcell, S=7005489464 | en_US |
dc.identifier.scopusauthorid | Sham, P=34573429300 | en_US |
dc.identifier.issnl | 0001-5652 | - |