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Article: Validation of single nucleotide polymorphism quantification in pooled DNA samples with SNaPIT™: A glycosylase-mediated methods for polymorphism detection method

TitleValidation of single nucleotide polymorphism quantification in pooled DNA samples with SNaPIT™: A glycosylase-mediated methods for polymorphism detection method
Authors
Issue Date2002
Citation
Applied Biochemistry And Biotechnology - Part B Molecular Biotechnology, 2002, v. 22 n. 3, p. 253-262 How to Cite?
AbstractAssociation studies using genome scans to identify quantitative trait loci for multifactorial disorders, with anything approaching reasonable power, have been compromised by the need for a very dense array of genetic markers and large numbers of affected individuals. These requirements impose enormous burdens on the genotyping capacity for most laboratories. DNA pooling has been proposed as a possible approach to reduce genotyping costs and effort. We report on the application of the SNaPIT™ technology to evaluate allele frequencies in pooled DNA samples and conclude that it offers a cost effective, efficient and accurate estimator and provides several advantages over competing technologies in this regard.
Persistent Identifierhttp://hdl.handle.net/10722/175925
ISSN
2015 Impact Factor: 1.752
2015 SCImago Journal Rankings: 0.787
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCurran, Sen_US
dc.contributor.authorHill, Len_US
dc.contributor.authorO'grady, Gen_US
dc.contributor.authorTuric, Den_US
dc.contributor.authorAsherson, Pen_US
dc.contributor.authorTaylor, Een_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorCraig, Ien_US
dc.contributor.authorVaughan, Pen_US
dc.date.accessioned2012-11-26T09:02:33Z-
dc.date.available2012-11-26T09:02:33Z-
dc.date.issued2002en_US
dc.identifier.citationApplied Biochemistry And Biotechnology - Part B Molecular Biotechnology, 2002, v. 22 n. 3, p. 253-262en_US
dc.identifier.issn1073-6085en_US
dc.identifier.urihttp://hdl.handle.net/10722/175925-
dc.description.abstractAssociation studies using genome scans to identify quantitative trait loci for multifactorial disorders, with anything approaching reasonable power, have been compromised by the need for a very dense array of genetic markers and large numbers of affected individuals. These requirements impose enormous burdens on the genotyping capacity for most laboratories. DNA pooling has been proposed as a possible approach to reduce genotyping costs and effort. We report on the application of the SNaPIT™ technology to evaluate allele frequencies in pooled DNA samples and conclude that it offers a cost effective, efficient and accurate estimator and provides several advantages over competing technologies in this regard.en_US
dc.languageengen_US
dc.relation.ispartofApplied Biochemistry and Biotechnology - Part B Molecular Biotechnologyen_US
dc.subject.meshChromosome Mapping - Methodsen_US
dc.subject.meshDna - Analysis - Genetics - Metabolismen_US
dc.subject.meshDna Glycosylasesen_US
dc.subject.meshDna Mutational Analysis - Methodsen_US
dc.subject.meshGene Frequency - Geneticsen_US
dc.subject.meshGenetic Testing - Methodsen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshN-Glycosyl Hydrolases - Metabolismen_US
dc.subject.meshPolymorphism, Single Nucleotide - Geneticsen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSequence Alignmenten_US
dc.titleValidation of single nucleotide polymorphism quantification in pooled DNA samples with SNaPIT™: A glycosylase-mediated methods for polymorphism detection methoden_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1385/MB:22:3:253en_US
dc.identifier.pmid12448880-
dc.identifier.scopuseid_2-s2.0-1842867186en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842867186&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue3en_US
dc.identifier.spage253en_US
dc.identifier.epage262en_US
dc.identifier.isiWOS:000178890300004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCurran, S=7103220956en_US
dc.identifier.scopusauthoridHill, L=7202617092en_US
dc.identifier.scopusauthoridO'Grady, G=6603937279en_US
dc.identifier.scopusauthoridTuric, D=6603622360en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US
dc.identifier.scopusauthoridTaylor, E=7403206584en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridCraig, I=7102548208en_US
dc.identifier.scopusauthoridVaughan, P=7103400874en_US

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