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Article: Influence of serotonergic transmission on response to olanzapine | Influencia de la transmisión serotoninérgica en la respuesta a olanzapina

TitleInfluence of serotonergic transmission on response to olanzapine | Influencia de la transmisión serotoninérgica en la respuesta a olanzapina
Authors
Issue Date2002
Citation
Actas Espanolas De Psiquiatria, 2002, v. 30 n. 5, p. 265-271 How to Cite?
AbstractIntroduction. This study aimed to investigate associations between the response to olanzapine and genetic variations (polymorphisms) in serotonergic transmission related genes in a sample of prospectively studied schizophrenic patients treated with this drug. Methodology. A total of 51 non-related patients with a DSM-IV diagnosis of schizophrenia were treated with olanzapine (mean dose: 12 mg/day; range: 5-25 mg) and followed-up for at least three months. Response to olanzapine was measured by the difference between baseline and post-treatment scores on the PANSS and GAS scales. The following polymorphisms were studied: serotonin receptor 5-HT2A (102-T/C, His452Tyr), serotonin receptor 5-HT2C (Cys23Ser, -330-GGT/-244-CT), and serotonin transporter (VNTR, 5-HTTLPR). Results. Global clinical improvement, measured with both the GAS and PANSS total scores, was observed. When patients were divided into responders and non-responders, the distribution of genotypic and allelic frequencies was similar to the one observed in previous studies with clozapine. When regression analyses were undertaken, polymorphism -330-GT/-244-CT of the 5-HT2C serotonin receptor and 5-HTTLPR of the serotonin transporter showed a tendency towards the association to olanzapine response. Conclusions. The present study provides preliminary evidence of the important role of variations in serotonin transmission related genes in determining clinical response to olanzapine. Considering previous studies, it can also be concluded that olanzapine and clozapine may have similar affinities to serotonin receptors.
Persistent Identifierhttp://hdl.handle.net/10722/175919
ISSN
2015 Impact Factor: 0.813
2015 SCImago Journal Rankings: 0.443
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMataPastor, Ien_US
dc.contributor.authorArranzCalderón, MJen_US
dc.contributor.authorBeperetUrmeneta, Men_US
dc.contributor.authorPérezNievas, Fen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKerwin, Ren_US
dc.date.accessioned2012-11-26T09:02:29Z-
dc.date.available2012-11-26T09:02:29Z-
dc.date.issued2002en_US
dc.identifier.citationActas Espanolas De Psiquiatria, 2002, v. 30 n. 5, p. 265-271en_US
dc.identifier.issn1139-9287en_US
dc.identifier.urihttp://hdl.handle.net/10722/175919-
dc.description.abstractIntroduction. This study aimed to investigate associations between the response to olanzapine and genetic variations (polymorphisms) in serotonergic transmission related genes in a sample of prospectively studied schizophrenic patients treated with this drug. Methodology. A total of 51 non-related patients with a DSM-IV diagnosis of schizophrenia were treated with olanzapine (mean dose: 12 mg/day; range: 5-25 mg) and followed-up for at least three months. Response to olanzapine was measured by the difference between baseline and post-treatment scores on the PANSS and GAS scales. The following polymorphisms were studied: serotonin receptor 5-HT2A (102-T/C, His452Tyr), serotonin receptor 5-HT2C (Cys23Ser, -330-GGT/-244-CT), and serotonin transporter (VNTR, 5-HTTLPR). Results. Global clinical improvement, measured with both the GAS and PANSS total scores, was observed. When patients were divided into responders and non-responders, the distribution of genotypic and allelic frequencies was similar to the one observed in previous studies with clozapine. When regression analyses were undertaken, polymorphism -330-GT/-244-CT of the 5-HT2C serotonin receptor and 5-HTTLPR of the serotonin transporter showed a tendency towards the association to olanzapine response. Conclusions. The present study provides preliminary evidence of the important role of variations in serotonin transmission related genes in determining clinical response to olanzapine. Considering previous studies, it can also be concluded that olanzapine and clozapine may have similar affinities to serotonin receptors.en_US
dc.languageengen_US
dc.relation.ispartofActas Espanolas de Psiquiatriaen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBenzodiazepinesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPirenzepine - Analogs & Derivatives - Pharmacokinetics - Therapeutic Useen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshSchizophrenia - Diagnosis - Drug Therapyen_US
dc.subject.meshSerotonin - Metabolismen_US
dc.subject.meshSerotonin Uptake Inhibitors - Pharmacokinetics - Therapeutic Useen_US
dc.titleInfluence of serotonergic transmission on response to olanzapine | Influencia de la transmisión serotoninérgica en la respuesta a olanzapinaen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12372221-
dc.identifier.scopuseid_2-s2.0-17044441392en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17044441392&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue5en_US
dc.identifier.spage265en_US
dc.identifier.epage271en_US
dc.identifier.isiWOS:000178795300001-
dc.publisher.placeSpainen_US
dc.identifier.scopusauthoridMataPastor, I=6505864029en_US
dc.identifier.scopusauthoridArranzCalderón, MJ=6503966263en_US
dc.identifier.scopusauthoridBeperetUrmeneta, M=6505573150en_US
dc.identifier.scopusauthoridPérezNievas, F=8089160900en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKerwin, R=7102904567en_US

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