File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Serotonergic Polymorphisms and Psychotic Disorders in Populations from North Spain

TitleSerotonergic Polymorphisms and Psychotic Disorders in Populations from North Spain
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2004, v. 126 B n. 1, p. 88-94 How to Cite?
AbstractThere is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and transporter. To test this hypothesis we investigated three genetic variants of the 5-HT2A receptor (-1438G/A, 102T/C and His452Tyr) and two variants of the serotonin transporter (a VNTR in the second intron and a 44 bp insertion/delition in the promoter region of the gene) in a clinical sample recruited in a human isolate and in surrounding areas in Northern Spain (N = 257) and in ethnically matched controls (N = 334). No clear association was found between 5-HT2A variants and psychosis. However, marginal associations were observed between the 5-HTT LPR and VNTR variants and psychosis (P ≤ 0.05) indicating a minor contribution to psychosis of genetic alterations in this gene. © 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/175902
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMata, Ien_US
dc.contributor.authorArranz, MJen_US
dc.contributor.authorPatiño, Aen_US
dc.contributor.authorLai, Ten_US
dc.contributor.authorBeperet, Men_US
dc.contributor.authorSierrasesumaga, Len_US
dc.contributor.authorClark, Den_US
dc.contributor.authorPerezNievas, Fen_US
dc.contributor.authorRichards, Len_US
dc.contributor.authorOrtuño, Fen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKerwin, RWen_US
dc.date.accessioned2012-11-26T09:02:20Z-
dc.date.available2012-11-26T09:02:20Z-
dc.date.issued2004en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2004, v. 126 B n. 1, p. 88-94en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175902-
dc.description.abstractThere is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and transporter. To test this hypothesis we investigated three genetic variants of the 5-HT2A receptor (-1438G/A, 102T/C and His452Tyr) and two variants of the serotonin transporter (a VNTR in the second intron and a 44 bp insertion/delition in the promoter region of the gene) in a clinical sample recruited in a human isolate and in surrounding areas in Northern Spain (N = 257) and in ethnically matched controls (N = 334). No clear association was found between 5-HT2A variants and psychosis. However, marginal associations were observed between the 5-HTT LPR and VNTR variants and psychosis (P ≤ 0.05) indicating a minor contribution to psychosis of genetic alterations in this gene. © 2003 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetics, Populationen_US
dc.subject.meshHaplotypes - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMinisatellite Repeats - Geneticsen_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.subject.meshPsychotic Disorders - Geneticsen_US
dc.subject.meshReceptor, Serotonin, 5-Ht2a - Geneticsen_US
dc.subject.meshSpain - Epidemiologyen_US
dc.titleSerotonergic Polymorphisms and Psychotic Disorders in Populations from North Spainen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.20150-
dc.identifier.pmid15048655-
dc.identifier.scopuseid_2-s2.0-12144290388en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12144290388&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume126 Ben_US
dc.identifier.issue1en_US
dc.identifier.spage88en_US
dc.identifier.epage94en_US
dc.identifier.isiWOS:000220607300017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMata, I=9638989000en_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridPatiño, A=7004235894en_US
dc.identifier.scopusauthoridLai, T=8089161300en_US
dc.identifier.scopusauthoridBeperet, M=18134905100en_US
dc.identifier.scopusauthoridSierrasesumaga, L=7004703567en_US
dc.identifier.scopusauthoridClark, D=7404789238en_US
dc.identifier.scopusauthoridPerezNievas, F=8089160900en_US
dc.identifier.scopusauthoridRichards, L=8089161500en_US
dc.identifier.scopusauthoridOrtuño, F=7003786852en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKerwin, RW=7102904567en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats