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Article: Obstetric complications in patients with schizophrenia and their unaffected siblings

TitleObstetric complications in patients with schizophrenia and their unaffected siblings
Authors
Issue Date2005
PublisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/eurpsy
Citation
European Psychiatry, 2005, v. 20 n. 1, p. 28-34 How to Cite?
AbstractObjective.- We sought to explore whether obstetric complications (OCs) are more likely to occur in the presence of familial/genetic susceptibility for schizophrenia or whether they themselves represent an independent environmental risk factor for schizophrenia. Methods.- The presence of OCs was assessed through maternal interview on 216 subjects, comprising 36 patients with schizophrenia from multiply affected families, 38 of their unaffected siblings, 31 schizophrenic patients with no family history of psychosis, 51 of their unaffected siblings and 60 normal comparison subjects. We examined the familiality of OCs and whether OCs were commoner in the patient and sibling groups than in the control group. Results.- OCs tended to cluster within families, especially in multiply affected families. Patients with schizophrenia, especially those from multiply affected families, had a significantly higher rate of OCs compared to normal comparison subjects, but there was no evidence for an elevated rate of OCs in unaffected siblings. Conclusion.- Our data provides little evidence for a link between OCs and genetic susceptibility to schizophrenia. If high rates of OCs are related to schizophrenia genes, this relationship is weak and will only be detected by very large sample sizes. © 2004 Elsevier SAS. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175901
ISSN
2015 Impact Factor: 3.912
2015 SCImago Journal Rankings: 1.540
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWalshe, Men_US
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorTaylor, Men_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorGrech, Aen_US
dc.contributor.authorSchulze, Ken_US
dc.contributor.authorBramon, Een_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:02:20Z-
dc.date.available2012-11-26T09:02:20Z-
dc.date.issued2005en_US
dc.identifier.citationEuropean Psychiatry, 2005, v. 20 n. 1, p. 28-34en_US
dc.identifier.issn0924-9338en_US
dc.identifier.urihttp://hdl.handle.net/10722/175901-
dc.description.abstractObjective.- We sought to explore whether obstetric complications (OCs) are more likely to occur in the presence of familial/genetic susceptibility for schizophrenia or whether they themselves represent an independent environmental risk factor for schizophrenia. Methods.- The presence of OCs was assessed through maternal interview on 216 subjects, comprising 36 patients with schizophrenia from multiply affected families, 38 of their unaffected siblings, 31 schizophrenic patients with no family history of psychosis, 51 of their unaffected siblings and 60 normal comparison subjects. We examined the familiality of OCs and whether OCs were commoner in the patient and sibling groups than in the control group. Results.- OCs tended to cluster within families, especially in multiply affected families. Patients with schizophrenia, especially those from multiply affected families, had a significantly higher rate of OCs compared to normal comparison subjects, but there was no evidence for an elevated rate of OCs in unaffected siblings. Conclusion.- Our data provides little evidence for a link between OCs and genetic susceptibility to schizophrenia. If high rates of OCs are related to schizophrenia genes, this relationship is weak and will only be detected by very large sample sizes. © 2004 Elsevier SAS. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/eurpsyen_US
dc.relation.ispartofEuropean Psychiatryen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshComorbidityen_US
dc.subject.meshFamily - Psychologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Disease - Genetics - Psychologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInterviews As Topicen_US
dc.subject.meshMaleen_US
dc.subject.meshMothers - Psychologyen_US
dc.subject.meshObstetric Labor Complications - Epidemiology - Psychologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Epidemiology - Geneticsen_US
dc.subject.meshSiblings - Psychologyen_US
dc.titleObstetric complications in patients with schizophrenia and their unaffected siblingsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.eurpsy.2004.07.007en_US
dc.identifier.pmid15642440-
dc.identifier.scopuseid_2-s2.0-12144280612en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12144280612&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.spage28en_US
dc.identifier.epage34en_US
dc.identifier.isiWOS:000226712800004-
dc.publisher.placeFranceen_US
dc.identifier.scopusauthoridWalshe, M=8855469300en_US
dc.identifier.scopusauthoridMcDonald, C=8749594800en_US
dc.identifier.scopusauthoridTaylor, M=35556198800en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridGrech, A=6602744459en_US
dc.identifier.scopusauthoridSchulze, K=7103137549en_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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