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Article: Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes

TitleJoint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes
Authors
Issue Date2004
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
Citation
American Journal Of Human Genetics, 2004, v. 74 n. 2, p. 348-356 How to Cite?
AbstractAttention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant genetic component, and theories of etiology include abnormalities in the dopaminergic system, with DRD4, DAT1, SNAP25, and DRD5 being implicated as major susceptibility genes. An initial report of association between ADHD and the common 148-bp allele of a microsatellite marker located 18.5 kb from the DRD5 gene has been followed by several studies showing nonsignificant trends toward association with the same allele. To establish the postulated association of the (CA)n repeat with ADHD, we collected genotypic information from 14 independent samples of probands and their parents, analyzed them individually and, in the absence of heterogeneity, analyzed them as a joint sample. The joint analysis showed association with the DRD5 locus (P = .00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes.
Persistent Identifierhttp://hdl.handle.net/10722/175900
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLowe, Nen_US
dc.contributor.authorKirley, Aen_US
dc.contributor.authorHawi, Zen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorWickham, Hen_US
dc.contributor.authorKratochvil, CJen_US
dc.contributor.authorSmith, SDen_US
dc.contributor.authorLee, SYen_US
dc.contributor.authorLevy, Fen_US
dc.contributor.authorKent, Len_US
dc.contributor.authorMiddle, Fen_US
dc.contributor.authorRohde, LAen_US
dc.contributor.authorRoman, Ten_US
dc.contributor.authorTahir, Een_US
dc.contributor.authorYazgan, Yen_US
dc.contributor.authorAsherson, Pen_US
dc.contributor.authorMil, Jen_US
dc.contributor.authorThapar, Aen_US
dc.contributor.authorPayton, Aen_US
dc.contributor.authorTodd, RDen_US
dc.contributor.authorStephens, Ten_US
dc.contributor.authorEbstein, RPen_US
dc.contributor.authorManor, Ien_US
dc.contributor.authorBarr, CLen_US
dc.contributor.authorWigg, KGen_US
dc.contributor.authorSinke, RJen_US
dc.contributor.authorBuitelaar, JKen_US
dc.contributor.authorSmalley, SLen_US
dc.contributor.authorNelson, SFen_US
dc.contributor.authorBiederman, Jen_US
dc.contributor.authorFaraone, SVen_US
dc.contributor.authorGill, Men_US
dc.date.accessioned2012-11-26T09:02:19Z-
dc.date.available2012-11-26T09:02:19Z-
dc.date.issued2004en_US
dc.identifier.citationAmerican Journal Of Human Genetics, 2004, v. 74 n. 2, p. 348-356en_US
dc.identifier.issn0002-9297en_US
dc.identifier.urihttp://hdl.handle.net/10722/175900-
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant genetic component, and theories of etiology include abnormalities in the dopaminergic system, with DRD4, DAT1, SNAP25, and DRD5 being implicated as major susceptibility genes. An initial report of association between ADHD and the common 148-bp allele of a microsatellite marker located 18.5 kb from the DRD5 gene has been followed by several studies showing nonsignificant trends toward association with the same allele. To establish the postulated association of the (CA)n repeat with ADHD, we collected genotypic information from 14 independent samples of probands and their parents, analyzed them individually and, in the absence of heterogeneity, analyzed them as a joint sample. The joint analysis showed association with the DRD5 locus (P = .00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes.en_US
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/en_US
dc.relation.ispartofAmerican Journal of Human Geneticsen_US
dc.subject.meshAttention Deficit Disorder With Hyperactivity - Classification - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshOdds Ratioen_US
dc.titleJoint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypesen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1086/381561en_US
dc.identifier.pmid14732906-
dc.identifier.scopuseid_2-s2.0-10744231602en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10744231602&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume74en_US
dc.identifier.issue2en_US
dc.identifier.spage348en_US
dc.identifier.epage356en_US
dc.identifier.isiWOS:000188860000015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLowe, N=23106270400en_US
dc.identifier.scopusauthoridKirley, A=6603183634en_US
dc.identifier.scopusauthoridHawi, Z=7004471941en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridWickham, H=6701762103en_US
dc.identifier.scopusauthoridKratochvil, CJ=25955410200en_US
dc.identifier.scopusauthoridSmith, SD=7406648635en_US
dc.identifier.scopusauthoridLee, SY=36485039100en_US
dc.identifier.scopusauthoridLevy, F=7202927202en_US
dc.identifier.scopusauthoridKent, L=7006258806en_US
dc.identifier.scopusauthoridMiddle, F=6603307514en_US
dc.identifier.scopusauthoridRohde, LA=35461622300en_US
dc.identifier.scopusauthoridRoman, T=7004356066en_US
dc.identifier.scopusauthoridTahir, E=6603210119en_US
dc.identifier.scopusauthoridYazgan, Y=36485679600en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US
dc.identifier.scopusauthoridMil, J=36485208000en_US
dc.identifier.scopusauthoridThapar, A=34572905300en_US
dc.identifier.scopusauthoridPayton, A=6701719161en_US
dc.identifier.scopusauthoridTodd, RD=7202843582en_US
dc.identifier.scopusauthoridStephens, T=36485596900en_US
dc.identifier.scopusauthoridEbstein, RP=7007152650en_US
dc.identifier.scopusauthoridManor, I=6701576599en_US
dc.identifier.scopusauthoridBarr, CL=35447356300en_US
dc.identifier.scopusauthoridWigg, KG=6602896419en_US
dc.identifier.scopusauthoridSinke, RJ=8958907900en_US
dc.identifier.scopusauthoridBuitelaar, JK=26640178500en_US
dc.identifier.scopusauthoridSmalley, SL=7005767429en_US
dc.identifier.scopusauthoridNelson, SF=7403078142en_US
dc.identifier.scopusauthoridBiederman, J=36013380100en_US
dc.identifier.scopusauthoridFaraone, SV=36047714700en_US
dc.identifier.scopusauthoridGill, M=35228962600en_US

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