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Article: The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample

TitleThe dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample
Authors
Issue Date2003
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
Citation
Molecular Psychiatry, 2003, v. 8 n. 4, p. 393-396 How to Cite?
AbstractGenetic variation of the dopamine transporter gene (DAT1) is of particular interest in the study of attention-deficit hyperactivity disorder (ADHD), since stimulant drugs interact directly with the transporter protein. Association between ADHD and the 10-repeat allele of a 40-bp VNTR polymorphism that lies within the 3′-UTR of DAT1 was first reported in 1995, a finding that has been replicated in at least six independent samples from Caucasian populations. We analysed the DAT1 polymorphism in a sample of 110 Taiwanese probands with a DSM-IV diagnosis of ADHD and found evidence of increased transmission of the 10-repeat allele using TRANSMIT (χ2=10.8, 1 d.f., p=0.001, OR=2.9, 95% CI 1.4-6.3). These data give rise to a similar odds ratio to that observed in Caucasian poplulations despite a far higher frequency of the risk allele in this Taiwanese population; 82.3% in the un-transmitted parental alleles and 94.5% in the ADHD probands. These data support the role of DAT1 in ADHD susceptibility among Asian populations.
Persistent Identifierhttp://hdl.handle.net/10722/175891
ISSN
2015 Impact Factor: 13.314
2015 SCImago Journal Rankings: 6.790
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, CKen_US
dc.contributor.authorChen, SLen_US
dc.contributor.authorMill, Jen_US
dc.contributor.authorHuang, YSen_US
dc.contributor.authorLin, SKen_US
dc.contributor.authorCurran, Sen_US
dc.contributor.authorPurcell, Sen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorAsherson, Pen_US
dc.date.accessioned2012-11-26T09:02:12Z-
dc.date.available2012-11-26T09:02:12Z-
dc.date.issued2003en_US
dc.identifier.citationMolecular Psychiatry, 2003, v. 8 n. 4, p. 393-396en_US
dc.identifier.issn1359-4184en_US
dc.identifier.urihttp://hdl.handle.net/10722/175891-
dc.description.abstractGenetic variation of the dopamine transporter gene (DAT1) is of particular interest in the study of attention-deficit hyperactivity disorder (ADHD), since stimulant drugs interact directly with the transporter protein. Association between ADHD and the 10-repeat allele of a 40-bp VNTR polymorphism that lies within the 3′-UTR of DAT1 was first reported in 1995, a finding that has been replicated in at least six independent samples from Caucasian populations. We analysed the DAT1 polymorphism in a sample of 110 Taiwanese probands with a DSM-IV diagnosis of ADHD and found evidence of increased transmission of the 10-repeat allele using TRANSMIT (χ2=10.8, 1 d.f., p=0.001, OR=2.9, 95% CI 1.4-6.3). These data give rise to a similar odds ratio to that observed in Caucasian poplulations despite a far higher frequency of the risk allele in this Taiwanese population; 82.3% in the un-transmitted parental alleles and 94.5% in the ADHD probands. These data support the role of DAT1 in ADHD susceptibility among Asian populations.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mpen_US
dc.relation.ispartofMolecular Psychiatryen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAllelesen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshAttention Deficit Disorder With Hyperactivity - Geneticsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDna Primersen_US
dc.subject.meshDopamine Plasma Membrane Transport Proteinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Glycoproteinsen_US
dc.subject.meshMembrane Transport Proteins - Geneticsen_US
dc.subject.meshMinisatellite Repeats - Geneticsen_US
dc.subject.meshNerve Tissue Proteinsen_US
dc.subject.meshParentsen_US
dc.subject.meshTaiwanen_US
dc.titleThe dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sampleen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.mp.4001238en_US
dc.identifier.pmid12740596-
dc.identifier.scopuseid_2-s2.0-0038629451en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038629451&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.issue4en_US
dc.identifier.spage393en_US
dc.identifier.epage396en_US
dc.identifier.isiWOS:000182646800007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChen, CK=7501961684en_US
dc.identifier.scopusauthoridChen, SL=7410254110en_US
dc.identifier.scopusauthoridMill, J=7006450209en_US
dc.identifier.scopusauthoridHuang, YS=23018475900en_US
dc.identifier.scopusauthoridLin, SK=7407607751en_US
dc.identifier.scopusauthoridCurran, S=7103220956en_US
dc.identifier.scopusauthoridPurcell, S=7005489464en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US

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