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Article: Genetic and environmental influences on psychological distress in the population: General Health Questionnaire analyses in UK twins

TitleGenetic and environmental influences on psychological distress in the population: General Health Questionnaire analyses in UK twins
Authors
Issue Date2003
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2003, v. 33 n. 5, p. 793-801 How to Cite?
AbstractBackground. The General Health Questionnaire (GHQ) is the most popular screening instrument for detecting psychiatric disorders in community samples. Using longitudinal data of a large sample of UK twin pairs, we explored (i) heritabilities of the four scales and the total score; (ii) the genetic stability over time; and (iii) the existence of differential heritable influences at the high (ill) and low (healthy) tail of the distribution. Method. At baseline we assessed the GHQ in 627 MZ and 1323 DZ female pairs and at a second occasion (3.5 years later) for a small subsample (90 MZ and 270 DZ pairs). Liability threshold models and raw ordinal maximum likelihood were used to estimate twin correlations and to fit longitudinal genetic models. We estimated extreme group heritabilities of the GHQ distribution by using a model-fitting implementation of the DeFries-Fulker regression method for selected twin data. Results. Heritabilities for Somatic Symptoms, Anxiety, Social Dysfunction, Depression and total score were 0.37, 0.40, 0.20, 0.42 and 0.44, respectively. The contribution of shared genetic factors to the correlations between time points is substantial for the total score (73%). Group heritabilities of 0.48 and 0.43 were estimated for the top and bottom 10% of the total GHQ score distribution, respectively. Conclusion. The overall heritability of the GHQ as a measure of psychosocial distress was substantial (44%), with all scales having significant additive genetic influences that persisted across time periods. Extreme group analyses suggest that the genetic control of resilience is as important as the genetic control of vulnerability.
Persistent Identifierhttp://hdl.handle.net/10722/175890
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRijsdijk, FVen_US
dc.contributor.authorSnieder, Hen_US
dc.contributor.authorOrmel, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorGoldberg, DPen_US
dc.contributor.authorSpector, TDen_US
dc.date.accessioned2012-11-26T09:02:12Z-
dc.date.available2012-11-26T09:02:12Z-
dc.date.issued2003en_US
dc.identifier.citationPsychological Medicine, 2003, v. 33 n. 5, p. 793-801en_US
dc.identifier.issn0033-2917en_US
dc.identifier.urihttp://hdl.handle.net/10722/175890-
dc.description.abstractBackground. The General Health Questionnaire (GHQ) is the most popular screening instrument for detecting psychiatric disorders in community samples. Using longitudinal data of a large sample of UK twin pairs, we explored (i) heritabilities of the four scales and the total score; (ii) the genetic stability over time; and (iii) the existence of differential heritable influences at the high (ill) and low (healthy) tail of the distribution. Method. At baseline we assessed the GHQ in 627 MZ and 1323 DZ female pairs and at a second occasion (3.5 years later) for a small subsample (90 MZ and 270 DZ pairs). Liability threshold models and raw ordinal maximum likelihood were used to estimate twin correlations and to fit longitudinal genetic models. We estimated extreme group heritabilities of the GHQ distribution by using a model-fitting implementation of the DeFries-Fulker regression method for selected twin data. Results. Heritabilities for Somatic Symptoms, Anxiety, Social Dysfunction, Depression and total score were 0.37, 0.40, 0.20, 0.42 and 0.44, respectively. The contribution of shared genetic factors to the correlations between time points is substantial for the total score (73%). Group heritabilities of 0.48 and 0.43 were estimated for the top and bottom 10% of the total GHQ score distribution, respectively. Conclusion. The overall heritability of the GHQ as a measure of psychosocial distress was substantial (44%), with all scales having significant additive genetic influences that persisted across time periods. Extreme group analyses suggest that the genetic control of resilience is as important as the genetic control of vulnerability.en_US
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_US
dc.relation.ispartofPsychological Medicineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDiseases In Twinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGreat Britain - Epidemiologyen_US
dc.subject.meshHealth Status Indicatorsen_US
dc.subject.meshHumansen_US
dc.subject.meshMental Disorders - Epidemiology - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshStress, Psychological - Epidemiology - Geneticsen_US
dc.subject.meshTwins, Dizygoticen_US
dc.subject.meshTwins, Monozygoticen_US
dc.titleGenetic and environmental influences on psychological distress in the population: General Health Questionnaire analyses in UK twinsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0033291703007451en_US
dc.identifier.pmid12877394-
dc.identifier.scopuseid_2-s2.0-0038447159en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038447159&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue5en_US
dc.identifier.spage793en_US
dc.identifier.epage801en_US
dc.identifier.isiWOS:000184362600005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridRijsdijk, FV=6701830835en_US
dc.identifier.scopusauthoridSnieder, H=7006990967en_US
dc.identifier.scopusauthoridOrmel, J=34572659400en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridGoldberg, DP=7401442597en_US
dc.identifier.scopusauthoridSpector, TD=35351391300en_US
dc.identifier.citeulike10230065-

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