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Article: Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia

TitleGenetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia
Authors
Issue Date2002
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2002, v. 99 n. 21, p. 13675-13680 How to Cite?
AbstractA map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 schizophrenic patients and 241 normal individuals from Canada were genotyped with this marker set. Two 1,400- and 65-kb regions contained markers associated with the disease. Two markers from the 65-kb region were also found to be associated to schizophrenia in a Russian sample. Two overlapping genes G72 and G30 transcribed in brain were experimentally annotated in this 65-kb region. Transfection experiments point to the existence of a 153-aa protein coded by the G72 gene. This protein is rapidly evolving in primates, is localized to endoplasmic reticulum/Golgi in transfected cells, is able to form multimers and specifically binds to carbohydrates. Yeast two-hybrid experiments with the G72 protein identified the enzyme D-amino acid oxidase (DAAO) as an interacting partner. DAAO is expressed in human brain where it oxidizes D-serine, a potent activator of N-methyl-D-aspartate type glutamate receptor. The interaction between G72 and DAAO was confirmed in vitro and resulted in activation of DAAO. Four SNP markers from DAAO were found to be associated with schizophrenia in the Canadian samples. Logistic regression revealed genetic interaction between associated SNPs in vicinity of two genes. The association of both DAAO and a new gene G72 from 13q34 with schizophrenia together with activation of DAAO activity by a G72 protein product points to the involvement of this N-methyl-D-aspartate receptor regulation pathway in schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/175877
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChumakov, Ien_US
dc.contributor.authorBlumenfeld, Men_US
dc.contributor.authorGuerassimenko, Oen_US
dc.contributor.authorCavarec, Len_US
dc.contributor.authorPalicio, Men_US
dc.contributor.authorAbderrahim, Hen_US
dc.contributor.authorBougueleret, Len_US
dc.contributor.authorBarry, Cen_US
dc.contributor.authorTanaka, Hen_US
dc.contributor.authorLa Rosa, Pen_US
dc.contributor.authorPuech, Aen_US
dc.contributor.authorTahri, Nen_US
dc.contributor.authorCohenAkenine, Aen_US
dc.contributor.authorDelabrosse, Sen_US
dc.contributor.authorLissarrague, Sen_US
dc.contributor.authorPicard, FPen_US
dc.contributor.authorMaurice, Ken_US
dc.contributor.authorEssioux, Len_US
dc.contributor.authorMillasseau, Pen_US
dc.contributor.authorGrel, Pen_US
dc.contributor.authorDebailleul, Ven_US
dc.contributor.authorSimon, AMen_US
dc.contributor.authorCaterina, Den_US
dc.contributor.authorDufaure, Ien_US
dc.contributor.authorMalekzadeh, Ken_US
dc.contributor.authorBelova, Men_US
dc.contributor.authorLuan, JJen_US
dc.contributor.authorBouillot, Men_US
dc.contributor.authorSambucy, JLen_US
dc.contributor.authorPrimas, Gen_US
dc.contributor.authorSaumier, Men_US
dc.contributor.authorBoubkiri, Nen_US
dc.contributor.authorMartinSaumier, Sen_US
dc.contributor.authorNasroune, Men_US
dc.contributor.authorPeixoto, Hen_US
dc.contributor.authorDelaye, Aen_US
dc.contributor.authorPinchot, Ven_US
dc.contributor.authorBastucci, Men_US
dc.contributor.authorGuillou, Sen_US
dc.contributor.authorChevillon, Men_US
dc.contributor.authorSainzFuertes, Ren_US
dc.contributor.authorMeguenni, Sen_US
dc.contributor.authorAurichCosta, Jen_US
dc.contributor.authorCherif, Den_US
dc.contributor.authorGimalac, Aen_US
dc.contributor.authorVan Duijn, Cen_US
dc.contributor.authorGauvreau, Den_US
dc.contributor.authorOuellette, Gen_US
dc.contributor.authorFortier, Ien_US
dc.contributor.authorRaelson, Jen_US
dc.contributor.authorSherbatich, Ten_US
dc.contributor.authorRiazanskaia, Nen_US
dc.contributor.authorRogaev, Een_US
dc.contributor.authorRaeymaekers, Pen_US
dc.contributor.authorAerssens, Jen_US
dc.contributor.authorKonings, Fen_US
dc.contributor.authorLuyten, Wen_US
dc.contributor.authorMacciardi, Fen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorStraub, REen_US
dc.contributor.authorWeinberger, DRen_US
dc.contributor.authorCohen, Nen_US
dc.contributor.authorCohen, Den_US
dc.date.accessioned2012-11-26T09:02:02Z-
dc.date.available2012-11-26T09:02:02Z-
dc.date.issued2002en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2002, v. 99 n. 21, p. 13675-13680en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/175877-
dc.description.abstractA map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 schizophrenic patients and 241 normal individuals from Canada were genotyped with this marker set. Two 1,400- and 65-kb regions contained markers associated with the disease. Two markers from the 65-kb region were also found to be associated to schizophrenia in a Russian sample. Two overlapping genes G72 and G30 transcribed in brain were experimentally annotated in this 65-kb region. Transfection experiments point to the existence of a 153-aa protein coded by the G72 gene. This protein is rapidly evolving in primates, is localized to endoplasmic reticulum/Golgi in transfected cells, is able to form multimers and specifically binds to carbohydrates. Yeast two-hybrid experiments with the G72 protein identified the enzyme D-amino acid oxidase (DAAO) as an interacting partner. DAAO is expressed in human brain where it oxidizes D-serine, a potent activator of N-methyl-D-aspartate type glutamate receptor. The interaction between G72 and DAAO was confirmed in vitro and resulted in activation of DAAO. Four SNP markers from DAAO were found to be associated with schizophrenia in the Canadian samples. Logistic regression revealed genetic interaction between associated SNPs in vicinity of two genes. The association of both DAAO and a new gene G72 from 13q34 with schizophrenia together with activation of DAAO activity by a G72 protein product points to the involvement of this N-methyl-D-aspartate receptor regulation pathway in schizophrenia.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Artificial, Bacterial - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 13 - Geneticsen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshD-Amino-Acid Oxidase - Genetics - Metabolismen_US
dc.subject.meshEnzyme Activationen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshReceptors, N-Methyl-D-Aspartate - Geneticsen_US
dc.subject.meshSchizophrenia - Genetics - Physiopathologyen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshTwo-Hybrid System Techniquesen_US
dc.titleGenetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.182412499en_US
dc.identifier.pmid12364586-
dc.identifier.scopuseid_2-s2.0-0037108758en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037108758&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume99en_US
dc.identifier.issue21en_US
dc.identifier.spage13675en_US
dc.identifier.epage13680en_US
dc.identifier.isiWOS:000178635700062-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10001010617-
dc.identifier.scopusauthoridChumakov, I=7005327316en_US
dc.identifier.scopusauthoridBlumenfeld, M=7003633740en_US
dc.identifier.scopusauthoridGuerassimenko, O=6507618121en_US
dc.identifier.scopusauthoridCavarec, L=6603132803en_US
dc.identifier.scopusauthoridPalicio, M=6506803774en_US
dc.identifier.scopusauthoridAbderrahim, H=6602763181en_US
dc.identifier.scopusauthoridBougueleret, L=6701823126en_US
dc.identifier.scopusauthoridBarry, C=22946487400en_US
dc.identifier.scopusauthoridTanaka, H=7406600711en_US
dc.identifier.scopusauthoridLa Rosa, P=36873011500en_US
dc.identifier.scopusauthoridPuech, A=7102678024en_US
dc.identifier.scopusauthoridTahri, N=6602536780en_US
dc.identifier.scopusauthoridCohenAkenine, A=6507486856en_US
dc.identifier.scopusauthoridDelabrosse, S=6507555299en_US
dc.identifier.scopusauthoridLissarrague, S=22947938300en_US
dc.identifier.scopusauthoridPicard, FP=35515487400en_US
dc.identifier.scopusauthoridMaurice, K=6602949978en_US
dc.identifier.scopusauthoridEssioux, L=6603321829en_US
dc.identifier.scopusauthoridMillasseau, P=6701797997en_US
dc.identifier.scopusauthoridGrel, P=22947002300en_US
dc.identifier.scopusauthoridDebailleul, V=6602652884en_US
dc.identifier.scopusauthoridSimon, AM=36989663800en_US
dc.identifier.scopusauthoridCaterina, D=6507124336en_US
dc.identifier.scopusauthoridDufaure, I=7801457784en_US
dc.identifier.scopusauthoridMalekzadeh, K=6507378327en_US
dc.identifier.scopusauthoridBelova, M=7003847267en_US
dc.identifier.scopusauthoridLuan, JJ=16203602900en_US
dc.identifier.scopusauthoridBouillot, M=36942667700en_US
dc.identifier.scopusauthoridSambucy, JL=6507191488en_US
dc.identifier.scopusauthoridPrimas, G=6505849122en_US
dc.identifier.scopusauthoridSaumier, M=6507350458en_US
dc.identifier.scopusauthoridBoubkiri, N=6506659108en_US
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dc.identifier.scopusauthoridNasroune, M=16550198800en_US
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dc.identifier.scopusauthoridDelaye, A=7003967620en_US
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dc.identifier.scopusauthoridGuillou, S=6603943762en_US
dc.identifier.scopusauthoridChevillon, M=6507043000en_US
dc.identifier.scopusauthoridSainzFuertes, R=6505999736en_US
dc.identifier.scopusauthoridMeguenni, S=6603562674en_US
dc.identifier.scopusauthoridAurichCosta, J=8439745900en_US
dc.identifier.scopusauthoridCherif, D=7003766952en_US
dc.identifier.scopusauthoridGimalac, A=6508247411en_US
dc.identifier.scopusauthoridVan Duijn, C=36037246700en_US
dc.identifier.scopusauthoridGauvreau, D=7003691699en_US
dc.identifier.scopusauthoridOuellette, G=7003294731en_US
dc.identifier.scopusauthoridFortier, I=6602608336en_US
dc.identifier.scopusauthoridRaelson, J=6506110507en_US
dc.identifier.scopusauthoridSherbatich, T=6508072068en_US
dc.identifier.scopusauthoridRiazanskaia, N=6508344407en_US
dc.identifier.scopusauthoridRogaev, E=35391858800en_US
dc.identifier.scopusauthoridRaeymaekers, P=7003678826en_US
dc.identifier.scopusauthoridAerssens, J=7004029873en_US
dc.identifier.scopusauthoridKonings, F=6602119907en_US
dc.identifier.scopusauthoridLuyten, W=15763156800en_US
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dc.identifier.scopusauthoridCohen, N=7401789829en_US
dc.identifier.scopusauthoridCohen, D=7404417964en_US

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