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Article: Soluble interleukin 2 receptor levels in families of people with schizophrenia

TitleSoluble interleukin 2 receptor levels in families of people with schizophrenia
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2002, v. 56 n. 3, p. 235-239 How to Cite?
AbstractBackground: Several authors have reported increased soluble interleukin 2 receptor (sIL2Rα) concentrations in schizophrenia. The aim of this work was to examine serum sIL2Rα in the first degree relatives of patients with schizophrenia. Methods: We sampled 51 first degree relatives of patients with DSM IIIR schizophrenia. These relatives were unaffected by psychosis and included nine fathers, thirteen mothers, seventeen sisters and twelve brothers. They were compared to 126 controls who were not pregnant, had no known autoimmune disorder and no intercurrent illness. Neither the controls, nor their first degree relatives, suffered from a psychotic illness. Serum sIL2Rα was analysed using a commercial ELISA preparation (Quantikine sIL2Rα immunoassay - R and D Systems, Inc.). We used non-parametric Mann Whitney U test and Spearman correlation throughout. SIL2Rα levels were adjusted for higher levels in females and with increasing age. Results: Adjusted mean sIL2Rα values of unaffected siblings, averaged within their families, were higher than controls (n=14, one-tailed p=0.027). There was no difference in sIL2Rα values between fathers or mothers and controls following regression for age and sex. Conclusion: Soluble interleukin 2 receptorα levels are increased in siblings of patients with schizophrenia. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175866
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGaughran, Fen_US
dc.contributor.authorO'neill, Een_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorDaly, RJen_US
dc.contributor.authorShanahan, Fen_US
dc.date.accessioned2012-11-26T09:01:54Z-
dc.date.available2012-11-26T09:01:54Z-
dc.date.issued2002en_US
dc.identifier.citationSchizophrenia Research, 2002, v. 56 n. 3, p. 235-239en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175866-
dc.description.abstractBackground: Several authors have reported increased soluble interleukin 2 receptor (sIL2Rα) concentrations in schizophrenia. The aim of this work was to examine serum sIL2Rα in the first degree relatives of patients with schizophrenia. Methods: We sampled 51 first degree relatives of patients with DSM IIIR schizophrenia. These relatives were unaffected by psychosis and included nine fathers, thirteen mothers, seventeen sisters and twelve brothers. They were compared to 126 controls who were not pregnant, had no known autoimmune disorder and no intercurrent illness. Neither the controls, nor their first degree relatives, suffered from a psychotic illness. Serum sIL2Rα was analysed using a commercial ELISA preparation (Quantikine sIL2Rα immunoassay - R and D Systems, Inc.). We used non-parametric Mann Whitney U test and Spearman correlation throughout. SIL2Rα levels were adjusted for higher levels in females and with increasing age. Results: Adjusted mean sIL2Rα values of unaffected siblings, averaged within their families, were higher than controls (n=14, one-tailed p=0.027). There was no difference in sIL2Rα values between fathers or mothers and controls following regression for age and sex. Conclusion: Soluble interleukin 2 receptorα levels are increased in siblings of patients with schizophrenia. © 2002 Elsevier Science B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNuclear Familyen_US
dc.subject.meshReceptors, Interleukin-2 - Blooden_US
dc.subject.meshSchizophrenia - Immunologyen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.titleSoluble interleukin 2 receptor levels in families of people with schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(01)00275-4en_US
dc.identifier.pmid12072172-
dc.identifier.scopuseid_2-s2.0-0036681184en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036681184&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue3en_US
dc.identifier.spage235en_US
dc.identifier.epage239en_US
dc.identifier.isiWOS:000176404300004-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridGaughran, F=6602336142en_US
dc.identifier.scopusauthoridO'Neill, E=35581015600en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridDaly, RJ=7103342062en_US
dc.identifier.scopusauthoridShanahan, F=7101814806en_US

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