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Article: Estimation of sib-pair IBD sharing and multipoint polymorphism information content by linear regression

TitleEstimation of sib-pair IBD sharing and multipoint polymorphism information content by linear regression
Authors
Issue Date2002
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244
Citation
Behavior Genetics, 2002, v. 32 n. 3, p. 211-220 How to Cite?
AbstractA simple method of estimating IBD sharing (τ) of sibling pairs from multipoint genotype data based on linear regression is presented. The new method is an extension of that developed by Fulker, Cherny, and Cardon (1995) and involves a measure of sib-pair specific information, W, defined as the difference between the unconditional variance of τ and the conditional variance of τ given the marker genotype data. When markers are not fully informative, the W method provides estimates closer to those obtained from the exact hidden Markov method (HMM) than the original Fulker method. Using W, we also derive a generalisation for the polymorphism information content (PIC) for multiple markers. This multipoint polymorphism information content (MPIC) can be evaluated at any location along a marker map and is proportional to the noncentrality parameter for linkage. We illustrate MPIC by assessing the relative information content of single nucleotide polymorphism (SNP) and microsatellite markers.
Persistent Identifierhttp://hdl.handle.net/10722/175861
ISSN
2015 Impact Factor: 3.268
2015 SCImago Journal Rankings: 1.457
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRijsdijk, FVen_US
dc.contributor.authorSham, PCen_US
dc.date.accessioned2012-11-26T09:01:52Z-
dc.date.available2012-11-26T09:01:52Z-
dc.date.issued2002en_US
dc.identifier.citationBehavior Genetics, 2002, v. 32 n. 3, p. 211-220en_US
dc.identifier.issn0001-8244en_US
dc.identifier.urihttp://hdl.handle.net/10722/175861-
dc.description.abstractA simple method of estimating IBD sharing (τ) of sibling pairs from multipoint genotype data based on linear regression is presented. The new method is an extension of that developed by Fulker, Cherny, and Cardon (1995) and involves a measure of sib-pair specific information, W, defined as the difference between the unconditional variance of τ and the conditional variance of τ given the marker genotype data. When markers are not fully informative, the W method provides estimates closer to those obtained from the exact hidden Markov method (HMM) than the original Fulker method. Using W, we also derive a generalisation for the polymorphism information content (PIC) for multiple markers. This multipoint polymorphism information content (MPIC) can be evaluated at any location along a marker map and is proportional to the noncentrality parameter for linkage. We illustrate MPIC by assessing the relative information content of single nucleotide polymorphism (SNP) and microsatellite markers.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244en_US
dc.relation.ispartofBehavior Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshGene Frequency - Geneticsen_US
dc.subject.meshGenetic Markers - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMarkov Chainsen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshNuclear Familyen_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshQuantitative Trait, Heritableen_US
dc.subject.meshRegression Analysisen_US
dc.titleEstimation of sib-pair IBD sharing and multipoint polymorphism information content by linear regressionen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1023/A:1016073113019en_US
dc.identifier.pmid12141782-
dc.identifier.scopuseid_2-s2.0-0036318070en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036318070&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue3en_US
dc.identifier.spage211en_US
dc.identifier.epage220en_US
dc.identifier.isiWOS:000176389000005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRijsdijk, FV=6701830835en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.citeulike2496839-

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