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Article: A twin study of genetic relationships between psychotic symptoms

TitleA twin study of genetic relationships between psychotic symptoms
Authors
Issue Date2002
PublisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.org
Citation
American Journal Of Psychiatry, 2002, v. 159 n. 4, p. 539-545 How to Cite?
AbstractObjective: Biometrical model fitting was applied to clinical data from twins to investigate whether operationally defined schizophrenic, schizoaffective, and manic syndromes share genetic risk factors. Method: Seventy-seven monozygotic and 89 same-sex dizygotic twin pairs in which the proband met the Research Diagnostic Criteria (RDC) for lifetime-ever schizophrenic, schizoaffective, or manic syndrome were ascertained from the Maudsley Twin Register in London. The syndromes were defined nonhierarchically. Correlations in liability were calculated for each syndrome in the monozygotic and dizygotic pairs and across the three pairings of schizophrenic-manic, schizophrenic-schizoaffective, and schizoaffective-manic syndromes both within probands and within pairs. For the three syndromes considered together, an independent pathway model was fitted. Results: The model fitting showed significant genetic correlations between all three syndromes. There was evidence of both common and syndrome-specific genetic contributions to the variance in liability to the schizophrenic and manic syndromes, but the genetic liability to the schizoaffective syndrome was entirely shared in common with the other two syndromes. In contrast, environmental liability to the schizoaffective syndrome was not shared with the other syndromes. Conclusions: If diagnostic hierarchies are relaxed, there is a degree of overlap in the genes contributing to RDC schizophrenic, schizoaffective, and manic syndromes. Supplementing the traditional approach of assigning a single main lifetime diagnosis with information on within-person comorbidity of psychotic syndromes may provide valuable information about the familial aggregation of psychotic symptoms.
Persistent Identifierhttp://hdl.handle.net/10722/175859
ISSN
2015 Impact Factor: 13.505
2015 SCImago Journal Rankings: 5.218
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCardno, AGen_US
dc.contributor.authorRijsdijk, FVen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorMcguffin, Pen_US
dc.date.accessioned2012-11-26T09:01:52Z-
dc.date.available2012-11-26T09:01:52Z-
dc.date.issued2002en_US
dc.identifier.citationAmerican Journal Of Psychiatry, 2002, v. 159 n. 4, p. 539-545en_US
dc.identifier.issn0002-953Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/175859-
dc.description.abstractObjective: Biometrical model fitting was applied to clinical data from twins to investigate whether operationally defined schizophrenic, schizoaffective, and manic syndromes share genetic risk factors. Method: Seventy-seven monozygotic and 89 same-sex dizygotic twin pairs in which the proband met the Research Diagnostic Criteria (RDC) for lifetime-ever schizophrenic, schizoaffective, or manic syndrome were ascertained from the Maudsley Twin Register in London. The syndromes were defined nonhierarchically. Correlations in liability were calculated for each syndrome in the monozygotic and dizygotic pairs and across the three pairings of schizophrenic-manic, schizophrenic-schizoaffective, and schizoaffective-manic syndromes both within probands and within pairs. For the three syndromes considered together, an independent pathway model was fitted. Results: The model fitting showed significant genetic correlations between all three syndromes. There was evidence of both common and syndrome-specific genetic contributions to the variance in liability to the schizophrenic and manic syndromes, but the genetic liability to the schizoaffective syndrome was entirely shared in common with the other two syndromes. In contrast, environmental liability to the schizoaffective syndrome was not shared with the other syndromes. Conclusions: If diagnostic hierarchies are relaxed, there is a degree of overlap in the genes contributing to RDC schizophrenic, schizoaffective, and manic syndromes. Supplementing the traditional approach of assigning a single main lifetime diagnosis with information on within-person comorbidity of psychotic syndromes may provide valuable information about the familial aggregation of psychotic symptoms.en_US
dc.languageengen_US
dc.publisherAmerican Psychiatric Publishing, Inc. The Journal's web site is located at http://ajp.psychiatryonline.orgen_US
dc.relation.ispartofAmerican Journal of Psychiatryen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBipolar Disorder - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshDiseases In Twinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLondonen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPsychotic Disorders - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshRegistriesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.subject.meshSocial Environmenten_US
dc.subject.meshTwins, Dizygotic - Geneticsen_US
dc.subject.meshTwins, Monozygotic - Geneticsen_US
dc.titleA twin study of genetic relationships between psychotic symptomsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1176/appi.ajp.159.4.539en_US
dc.identifier.pmid11925290-
dc.identifier.scopuseid_2-s2.0-0036212511en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036212511&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume159en_US
dc.identifier.issue4en_US
dc.identifier.spage539en_US
dc.identifier.epage545en_US
dc.identifier.isiWOS:000174800000006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCardno, AG=7004499892en_US
dc.identifier.scopusauthoridRijsdijk, FV=6701830835en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US

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