File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Transmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population

TitleTransmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population
Authors
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2001, v. 49 n. 1-2, p. 73-78 How to Cite?
AbstractOur goal was to evaluate the role of HLA in the risk of developing schizophrenia, in a Han Chinese population. In several Japanese studies, there is evidence of association with DR1 and schizophrenia. A variety of other associations have been reported in other populations, including negative associations with DQβ*0602 and positive associations with DR1*0101. Using sequence specific oligonucleotides, we genotyped four HLA markers (DRB1, DQA1, DQB1 and DPB1) in 165 family trios, consisting of Han Chinese schizophrenic subjects and their parents. Individual markers were analysed for transmission distortion in the trios using the transmission disequilibrium test. Multiple haplotype transmission was performed using the program TRANSMIT v2.5. The four markers were in strong linkage disequilibrium with each other (P value from 0.002 to 0). There was no evidence of overall transmission disequilibrium for each of the four loci. For DRB1, we did not find transmission distortion for the DRB1*04 and DRB1*08 alleles, as reported previously, but the DRB1*03 allele was preferentially not transmitted (P = 0.009), and the DRB1*13 allele was preferentially transmitted from parents to schizophrenic offspring (P = 0.041). Using haplotypes of pairs of markers, a significant global P value of 0.019 was achieved when using DRB1 and DQA1, mainly as a result of the excess transmission of DRB1*13-DQA1*01 (P = 0.012) and a deficit in transmission of DRB1*03-DQA1*05 (P = 0.002). In summary, we did not confirm any of the specific HLA allelic associations reported previously in Japanese or other populations. However, our results are compatible with the view that this region of HLA might contain a susceptibility gene which is in linkage disequilibrium with DRB1 and DQA1 genes. © 2001 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/175852
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorUnderhill, Jen_US
dc.contributor.authorLiu, XHen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorDonaldson, Pen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorWright, Pen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:01:49Z-
dc.date.available2012-11-26T09:01:49Z-
dc.date.issued2001en_US
dc.identifier.citationSchizophrenia Research, 2001, v. 49 n. 1-2, p. 73-78en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175852-
dc.description.abstractOur goal was to evaluate the role of HLA in the risk of developing schizophrenia, in a Han Chinese population. In several Japanese studies, there is evidence of association with DR1 and schizophrenia. A variety of other associations have been reported in other populations, including negative associations with DQβ*0602 and positive associations with DR1*0101. Using sequence specific oligonucleotides, we genotyped four HLA markers (DRB1, DQA1, DQB1 and DPB1) in 165 family trios, consisting of Han Chinese schizophrenic subjects and their parents. Individual markers were analysed for transmission distortion in the trios using the transmission disequilibrium test. Multiple haplotype transmission was performed using the program TRANSMIT v2.5. The four markers were in strong linkage disequilibrium with each other (P value from 0.002 to 0). There was no evidence of overall transmission disequilibrium for each of the four loci. For DRB1, we did not find transmission distortion for the DRB1*04 and DRB1*08 alleles, as reported previously, but the DRB1*03 allele was preferentially not transmitted (P = 0.009), and the DRB1*13 allele was preferentially transmitted from parents to schizophrenic offspring (P = 0.041). Using haplotypes of pairs of markers, a significant global P value of 0.019 was achieved when using DRB1 and DQA1, mainly as a result of the excess transmission of DRB1*13-DQA1*01 (P = 0.012) and a deficit in transmission of DRB1*03-DQA1*05 (P = 0.002). In summary, we did not confirm any of the specific HLA allelic associations reported previously in Japanese or other populations. However, our results are compatible with the view that this region of HLA might contain a susceptibility gene which is in linkage disequilibrium with DRB1 and DQA1 genes. © 2001 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshChromosomes, Human, Pair 6 - Geneticsen_US
dc.subject.meshGene Frequency - Geneticsen_US
dc.subject.meshHla Antigens - Geneticsen_US
dc.subject.meshHla-B Antigens - Geneticsen_US
dc.subject.meshHla-Dq Antigens - Geneticsen_US
dc.subject.meshHla-Dq Alpha-Chainsen_US
dc.subject.meshHla-Dq Beta-Chainsen_US
dc.subject.meshHla-Dr Antigens - Geneticsen_US
dc.subject.meshHaplotypes - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibrium - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshSchizophrenia - Ethnology - Geneticsen_US
dc.titleTransmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(00)00111-0en_US
dc.identifier.pmid11343866-
dc.identifier.scopuseid_2-s2.0-0035870945en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035870945&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue1-2en_US
dc.identifier.spage73en_US
dc.identifier.epage78en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridUnderhill, J=7006500448en_US
dc.identifier.scopusauthoridLiu, XH=7409286408en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridDonaldson, P=7102342412en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridWright, P=7404316244en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats