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Article: QTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptoms

TitleQTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptoms
Authors
Issue Date2001
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2001, v. 105 n. 4, p. 387-393 How to Cite?
AbstractCurrent developments in molecular genetics have led to a rapid increase in research aimed at the identification of genetic variation that influences complex human phenotypes. One phenotype that has aroused a great deal of interest is the behavioral trait hyperactivity and the related clinical disorder attention-deficit hyperactivity disorder (ADHD). The driving force behind the molecular genetic research in this area is the overwhelming evidence from quantitative genetic studies that show high heritablility (h2 = 0.7-0.9) for the behaviors characterizing the diagnosis of ADHD, whether the disorder is viewed as a categorical entity or a continuous trait. To date, molecular studies have aimed at identifying susceptibility genes for ADHD, defined using operational diagnostic criteria, and have focused on variation within genes that regulate dopamine neurotransmission. Several studies report ADHD to be associated with the 7-repeat allele of a 48 bp repeat polymorphism (DRD4-7) in exon 3 of the dopamine D4 receptor gene (DRD4). In this study, we take a dimensional perspective of ADHD and examine the relationship of this DRD4 polymorphism in a sample of children selected from the general population on the basis of high and low scores on the five ADHD items of the Strengths and Difficulties Questionnaire (SDQ) as rated by their parents. We found a significant relationship between DRD4-7 and high-scoring individuals [chi-square = 8.63; P = 0.003; OR = 2.09 (95% CI 1.24 < OR < 3.54), F-statistic = 7.245; P = 0.008]. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/175849
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCurran, Sen_US
dc.contributor.authorMill, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorRijsdijk, Fen_US
dc.contributor.authorMarusic, Ken_US
dc.contributor.authorTaylor, Een_US
dc.contributor.authorAsherson, Pen_US
dc.date.accessioned2012-11-26T09:01:47Z-
dc.date.available2012-11-26T09:01:47Z-
dc.date.issued2001en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2001, v. 105 n. 4, p. 387-393en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175849-
dc.description.abstractCurrent developments in molecular genetics have led to a rapid increase in research aimed at the identification of genetic variation that influences complex human phenotypes. One phenotype that has aroused a great deal of interest is the behavioral trait hyperactivity and the related clinical disorder attention-deficit hyperactivity disorder (ADHD). The driving force behind the molecular genetic research in this area is the overwhelming evidence from quantitative genetic studies that show high heritablility (h2 = 0.7-0.9) for the behaviors characterizing the diagnosis of ADHD, whether the disorder is viewed as a categorical entity or a continuous trait. To date, molecular studies have aimed at identifying susceptibility genes for ADHD, defined using operational diagnostic criteria, and have focused on variation within genes that regulate dopamine neurotransmission. Several studies report ADHD to be associated with the 7-repeat allele of a 48 bp repeat polymorphism (DRD4-7) in exon 3 of the dopamine D4 receptor gene (DRD4). In this study, we take a dimensional perspective of ADHD and examine the relationship of this DRD4 polymorphism in a sample of children selected from the general population on the basis of high and low scores on the five ADHD items of the Strengths and Difficulties Questionnaire (SDQ) as rated by their parents. We found a significant relationship between DRD4-7 and high-scoring individuals [chi-square = 8.63; P = 0.003; OR = 2.09 (95% CI 1.24 < OR < 3.54), F-statistic = 7.245; P = 0.008]. © 2001 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAllelesen_US
dc.subject.meshAttention Deficit Disorder With Hyperactivity - Genetics - Pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDna - Geneticsen_US
dc.subject.meshExonsen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMinisatellite Repeats - Geneticsen_US
dc.subject.meshParentsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshQuantitative Trait, Heritableen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshReceptors, Dopamine D4en_US
dc.subject.meshTeachingen_US
dc.titleQTL association analysis of the DRD4 exon 3 VNTR polymorphism in a population sample of children screened with a parent rating scale for ADHD symptomsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.1366en_US
dc.identifier.pmid11378855-
dc.identifier.scopuseid_2-s2.0-0035826545en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035826545&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume105en_US
dc.identifier.issue4en_US
dc.identifier.spage387en_US
dc.identifier.epage393en_US
dc.identifier.isiWOS:000169116200015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCurran, S=7103220956en_US
dc.identifier.scopusauthoridMill, J=7006450209en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_US
dc.identifier.scopusauthoridMarusic, K=6505500293en_US
dc.identifier.scopusauthoridTaylor, E=7403206584en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US

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