File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Familiality of symptom dimensions in schizophrenia

TitleFamiliality of symptom dimensions in schizophrenia
Authors
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2001, v. 47 n. 2-3, p. 223-232 How to Cite?
AbstractThe division of schizophrenic symptoms into three core dimensions - psychomotor poverty, reality distortion, and disorganisation - is well established. When factor analytic studies have included affective symptoms they have identified two additional dimensions - manic and depressive. Whether these five dimensions represent underlying psychopathology of a genetic or environmental aetiology remains unclear. The aims of this study were to perform factor analysis of symptoms in a group of familial schizophrenic patients and to investigate the familiality of the symptom dimensions identified, and their relationship to clinical characteristics. Symptoms were recorded, using the Operational Criteria Checklist for Psychotic Illness, for 155 Caucasian subjects with an RDC diagnosis of schizophrenia, schizoaffective disorder, or psychosis of unknown origin, from 61 families multiply affected with schizophrenia. Factor analysis indicated five symptom dimensions: depressive, manic, reality distortion, disorganisation, and psychomotor poverty. The psychomotor poverty, disorganisation, and manic dimensions were shown to be familial. Psychomotor poverty, disorganisation, and reality distortion were all associated with deterioration from premorbid functioning and chronic course of the disorder. In addition, psychomotor poverty was significantly related to poor premorbid functioning, as well as to single marital status and unemployment at onset. Disorganisation was significantly related to single marital status and unemployment at onset. The familiality of the psychomotor poverty, disorganisation, and manic dimensions supports their use in the delineation of homogeneous subsets for genetic studies. © 2001 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/175846
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWickham, Hen_US
dc.contributor.authorWalsh, Cen_US
dc.contributor.authorAsherson, Pen_US
dc.contributor.authorTaylor, Cen_US
dc.contributor.authorSigmundson, Ten_US
dc.contributor.authorGill, Men_US
dc.contributor.authorOwen, MJen_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorSham, Pen_US
dc.date.accessioned2012-11-26T09:01:46Z-
dc.date.available2012-11-26T09:01:46Z-
dc.date.issued2001en_US
dc.identifier.citationSchizophrenia Research, 2001, v. 47 n. 2-3, p. 223-232en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175846-
dc.description.abstractThe division of schizophrenic symptoms into three core dimensions - psychomotor poverty, reality distortion, and disorganisation - is well established. When factor analytic studies have included affective symptoms they have identified two additional dimensions - manic and depressive. Whether these five dimensions represent underlying psychopathology of a genetic or environmental aetiology remains unclear. The aims of this study were to perform factor analysis of symptoms in a group of familial schizophrenic patients and to investigate the familiality of the symptom dimensions identified, and their relationship to clinical characteristics. Symptoms were recorded, using the Operational Criteria Checklist for Psychotic Illness, for 155 Caucasian subjects with an RDC diagnosis of schizophrenia, schizoaffective disorder, or psychosis of unknown origin, from 61 families multiply affected with schizophrenia. Factor analysis indicated five symptom dimensions: depressive, manic, reality distortion, disorganisation, and psychomotor poverty. The psychomotor poverty, disorganisation, and manic dimensions were shown to be familial. Psychomotor poverty, disorganisation, and reality distortion were all associated with deterioration from premorbid functioning and chronic course of the disorder. In addition, psychomotor poverty was significantly related to poor premorbid functioning, as well as to single marital status and unemployment at onset. Disorganisation was significantly related to single marital status and unemployment at onset. The familiality of the psychomotor poverty, disorganisation, and manic dimensions supports their use in the delineation of homogeneous subsets for genetic studies. © 2001 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshBipolar Disorder - Diagnosisen_US
dc.subject.meshDepression - Diagnosisen_US
dc.subject.meshFactor Analysis, Statisticalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.titleFamiliality of symptom dimensions in schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(00)00098-0en_US
dc.identifier.pmid11278139-
dc.identifier.scopuseid_2-s2.0-0035280657en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035280657&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume47en_US
dc.identifier.issue2-3en_US
dc.identifier.spage223en_US
dc.identifier.epage232en_US
dc.identifier.isiWOS:000167537400013-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridWickham, H=6701762103en_US
dc.identifier.scopusauthoridWalsh, C=7401952516en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US
dc.identifier.scopusauthoridTaylor, C=7404823513en_US
dc.identifier.scopusauthoridSigmundson, T=15722587500en_US
dc.identifier.scopusauthoridGill, M=35228962600en_US
dc.identifier.scopusauthoridOwen, MJ=36044041500en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats