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Article: A novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease

TitleA novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's disease
Authors
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHG
Citation
Annals Of Human Genetics, 2001, v. 65 n. 5, p. 473-482 How to Cite?
AbstractA number of methods have previously been described which carry out linkage analysis considering information for two or more loci simultaneously. Apart from some ad hoc methods such as analysing subsamples, these methods use information regarding linkage at all loci under consideration. However, if the actual genotype-specific effects are known for some loci then it would be preferable to consider the genotypes of these loci directly, rather than the amount of allele-sharing they demonstrate. Here we present an extension to our likelihood-based method of model-free linkage analysis as implemented in the MFLINK program. This allows the incorporation of liability classes. The genotypes of a locus known to affect risk can be used to assign subjects to liability classes prior to carrying out linkage tests at other loci. An example application is presented for genome scan data on Alzheimer's disease with analysis conditional on Apoliprotein E (APOE) genotypes. The results provide support for the existence of additional susceptibility loci linked to D10S1211 and to D12S358.
Persistent Identifierhttp://hdl.handle.net/10722/175845
ISSN
2015 Impact Factor: 1.889
2015 SCImago Journal Rankings: 1.191
References

 

DC FieldValueLanguage
dc.contributor.authorCurtis, Den_US
dc.contributor.authorNorth, BVen_US
dc.contributor.authorSham, PCen_US
dc.date.accessioned2012-11-26T09:01:45Z-
dc.date.available2012-11-26T09:01:45Z-
dc.date.issued2001en_US
dc.identifier.citationAnnals Of Human Genetics, 2001, v. 65 n. 5, p. 473-482en_US
dc.identifier.issn0003-4800en_US
dc.identifier.urihttp://hdl.handle.net/10722/175845-
dc.description.abstractA number of methods have previously been described which carry out linkage analysis considering information for two or more loci simultaneously. Apart from some ad hoc methods such as analysing subsamples, these methods use information regarding linkage at all loci under consideration. However, if the actual genotype-specific effects are known for some loci then it would be preferable to consider the genotypes of these loci directly, rather than the amount of allele-sharing they demonstrate. Here we present an extension to our likelihood-based method of model-free linkage analysis as implemented in the MFLINK program. This allows the incorporation of liability classes. The genotypes of a locus known to affect risk can be used to assign subjects to liability classes prior to carrying out linkage tests at other loci. An example application is presented for genome scan data on Alzheimer's disease with analysis conditional on Apoliprotein E (APOE) genotypes. The results provide support for the existence of additional susceptibility loci linked to D10S1211 and to D12S358.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHGen_US
dc.relation.ispartofAnnals of Human Geneticsen_US
dc.subject.meshAlzheimer Disease - Geneticsen_US
dc.subject.meshChromosome Mapping - Methodsen_US
dc.subject.meshHumansen_US
dc.titleA novel method of two-locus linkage analysis applied to a genome scan for late onset Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11806855-
dc.identifier.scopuseid_2-s2.0-0035211948en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035211948&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume65en_US
dc.identifier.issue5en_US
dc.identifier.spage473en_US
dc.identifier.epage482en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCurtis, D=14633020700en_US
dc.identifier.scopusauthoridNorth, BV=7005058731en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US

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