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Article: Verbal fluency in patients with schizophrenia and affective psychoses and their first-degree relatives

TitleVerbal fluency in patients with schizophrenia and affective psychoses and their first-degree relatives
Authors
Issue Date2001
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2001, v. 31 n. 4, p. 695-704 How to Cite?
AbstractBackground. Schizophrenic patients are known to have neuropsychological deficits including impaired verbal fluency, but it is not clear whether this latter deficit is: (a) a consequence of overall intellectual deficit; (b) shared with affective psychotic patients; or (c) shared by the relatives of schizophrenic patients; and (d) shared by the relatives of affective psychotic patients. Methods. We administered Thurstone's Verbal Fluency Test to 45 schizophrenic patients and 72 of their relatives, and 30 affective psychotic patients and 53 of their relatives. Subjects were asked to generate as many words as possible beginning with the letters 'C' and 'S' and the total was taken as the dependent variable. Subjects also completed the National Adult Reading Test (NART) to provide a measure of (pre-morbid) IQ. Results. Schizophrenic patients generated significantly fewer words than affective psychotic patients, however adjusting for NART this became non-significant. Schizophrenic (but not affective psychotic) patients generated significantly fewer words than their relatives; again adjusting for NART this became non-significant. Patients who had been exposed to obstetric complications (OC+) and those who had not (OC-) had similarly poor verbal fluency scores. Relatives of OC+ schizophrenic patients had superior verbal fluency than relatives of OC- schizophrenic patients and this remained significant after adjustment for NART. Conclusions. The results suggest that some families transmit impairment in verbal fluency as part of a pattern of lower overall IQ. However, in other families, relatives show largely normal neuropsychological function, and the poorer verbal performance of the schizophrenic member appears to have arisen secondary to his/her exposure to OCs.
Persistent Identifierhttp://hdl.handle.net/10722/175841
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
References

 

DC FieldValueLanguage
dc.contributor.authorGilvarry, CMen_US
dc.contributor.authorRussell, Aen_US
dc.contributor.authorJones, Pen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorHemsley, Den_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:01:43Z-
dc.date.available2012-11-26T09:01:43Z-
dc.date.issued2001en_US
dc.identifier.citationPsychological Medicine, 2001, v. 31 n. 4, p. 695-704en_US
dc.identifier.issn0033-2917en_US
dc.identifier.urihttp://hdl.handle.net/10722/175841-
dc.description.abstractBackground. Schizophrenic patients are known to have neuropsychological deficits including impaired verbal fluency, but it is not clear whether this latter deficit is: (a) a consequence of overall intellectual deficit; (b) shared with affective psychotic patients; or (c) shared by the relatives of schizophrenic patients; and (d) shared by the relatives of affective psychotic patients. Methods. We administered Thurstone's Verbal Fluency Test to 45 schizophrenic patients and 72 of their relatives, and 30 affective psychotic patients and 53 of their relatives. Subjects were asked to generate as many words as possible beginning with the letters 'C' and 'S' and the total was taken as the dependent variable. Subjects also completed the National Adult Reading Test (NART) to provide a measure of (pre-morbid) IQ. Results. Schizophrenic patients generated significantly fewer words than affective psychotic patients, however adjusting for NART this became non-significant. Schizophrenic (but not affective psychotic) patients generated significantly fewer words than their relatives; again adjusting for NART this became non-significant. Patients who had been exposed to obstetric complications (OC+) and those who had not (OC-) had similarly poor verbal fluency scores. Relatives of OC+ schizophrenic patients had superior verbal fluency than relatives of OC- schizophrenic patients and this remained significant after adjustment for NART. Conclusions. The results suggest that some families transmit impairment in verbal fluency as part of a pattern of lower overall IQ. However, in other families, relatives show largely normal neuropsychological function, and the poorer verbal performance of the schizophrenic member appears to have arisen secondary to his/her exposure to OCs.en_US
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_US
dc.relation.ispartofPsychological Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshCognition Disorders - Psychologyen_US
dc.subject.meshFamily Healthen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntelligence Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMood Disorders - Complications - Genetics - Psychologyen_US
dc.subject.meshPedigreeen_US
dc.subject.meshSchizophrenia - Complications - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.subject.meshVerbal Behavioren_US
dc.titleVerbal fluency in patients with schizophrenia and affective psychoses and their first-degree relativesen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0033291701003816en_US
dc.identifier.pmid11352371-
dc.identifier.scopuseid_2-s2.0-0035025139en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035025139&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue4en_US
dc.identifier.spage695en_US
dc.identifier.epage704en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridGilvarry, CM=6701857173en_US
dc.identifier.scopusauthoridRussell, A=35556811900en_US
dc.identifier.scopusauthoridJones, P=36078972900en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridHemsley, D=7005185516en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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