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- Publisher Website: 10.1086/320593
- Scopus: eid_2-s2.0-0034987802
- PMID: 11353401
- WOS: WOS:000169094600025
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Article: Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs
Title | Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs |
---|---|
Authors | |
Issue Date | 2001 |
Publisher | Cell Press. The Journal's web site is located at http://www.cell.com/AJHG/ |
Citation | American Journal Of Human Genetics, 2001, v. 68 n. 6, p. 1527-1532 How to Cite? |
Abstract | The Haseman-Elston regression method offers a simpler alternative to variance-components (VC) models, for the linkage analysis of quantitative traits. However, even the "revisited" method, which uses the cross-product - rather than the squared difference - in sib trait values, is, in general, less powerful than VC models. In this report, we clarify the relative efficiencies of existing Haseman-Elston methods and show how a new Haseman-Elston method can be constructed to have power equivalent to that of VC models. This method uses as the dependent variable a linear combination of squared sums and squared differences, in which the weights are determined by the overall trait correlation between sibs in a population. We show how this method can be used for both the selection of maximally informative sib pairs for genotyping and the subsequent analysis of such selected samples. |
Persistent Identifier | http://hdl.handle.net/10722/175840 |
ISSN | 2023 Impact Factor: 8.1 2023 SCImago Journal Rankings: 4.516 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sham, PC | en_US |
dc.contributor.author | Purcell, S | en_US |
dc.date.accessioned | 2012-11-26T09:01:43Z | - |
dc.date.available | 2012-11-26T09:01:43Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | American Journal Of Human Genetics, 2001, v. 68 n. 6, p. 1527-1532 | en_US |
dc.identifier.issn | 0002-9297 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175840 | - |
dc.description.abstract | The Haseman-Elston regression method offers a simpler alternative to variance-components (VC) models, for the linkage analysis of quantitative traits. However, even the "revisited" method, which uses the cross-product - rather than the squared difference - in sib trait values, is, in general, less powerful than VC models. In this report, we clarify the relative efficiencies of existing Haseman-Elston methods and show how a new Haseman-Elston method can be constructed to have power equivalent to that of VC models. This method uses as the dependent variable a linear combination of squared sums and squared differences, in which the weights are determined by the overall trait correlation between sibs in a population. We show how this method can be used for both the selection of maximally informative sib pairs for genotyping and the subsequent analysis of such selected samples. | en_US |
dc.language | eng | en_US |
dc.publisher | Cell Press. The Journal's web site is located at http://www.cell.com/AJHG/ | en_US |
dc.relation.ispartof | American Journal of Human Genetics | en_US |
dc.subject.mesh | Chi-Square Distribution | en_US |
dc.subject.mesh | Chromosome Mapping - Methods - Statistics & Numerical Data | en_US |
dc.subject.mesh | Computer Simulation | en_US |
dc.subject.mesh | Genetic Linkage - Genetics | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Matched-Pair Analysis | en_US |
dc.subject.mesh | Nuclear Family | en_US |
dc.subject.mesh | Quantitative Trait, Heritable | en_US |
dc.subject.mesh | Regression Analysis | en_US |
dc.title | Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, PC=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1086/320593 | en_US |
dc.identifier.pmid | 11353401 | - |
dc.identifier.scopus | eid_2-s2.0-0034987802 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034987802&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 68 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 1527 | en_US |
dc.identifier.epage | 1532 | en_US |
dc.identifier.isi | WOS:000169094600025 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_US |
dc.identifier.scopusauthorid | Purcell, S=7005489464 | en_US |
dc.identifier.issnl | 0002-9297 | - |