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Article: Analytic power calculation for QTL linkage analysis of small pedigrees

TitleAnalytic power calculation for QTL linkage analysis of small pedigrees
Authors
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejhg
Citation
European Journal Of Human Genetics, 2001, v. 9 n. 5, p. 335-340 How to Cite?
AbstractPower calculation for QTL linkage analysis can be performed via simple algebraic formulas for small pedigrees, but requires intensive computation for large pedigrees, in order to evaluate the expectation of the test statistic over all possible inheritance vectors at the test position. In this report, we show that the non-centrality parameter for an arbitrary pedigree can be approximated by the sum of the variances of the correlations between all pairs of relatives, each variance being weighted by a factor that is determined by the mean correlation of the pair. We show that this approximation is sufficiently accurate for practical purposes in small to moderately large pedigrees, and that large sibships are more efficient than other family structures under a range of genetic models.
Persistent Identifierhttp://hdl.handle.net/10722/175839
ISSN
2015 Impact Factor: 4.58
2015 SCImago Journal Rankings: 2.077
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRijsdijk, FVen_US
dc.contributor.authorHewitt, JKen_US
dc.contributor.authorSham, PCen_US
dc.date.accessioned2012-11-26T09:01:42Z-
dc.date.available2012-11-26T09:01:42Z-
dc.date.issued2001en_US
dc.identifier.citationEuropean Journal Of Human Genetics, 2001, v. 9 n. 5, p. 335-340en_US
dc.identifier.issn1018-4813en_US
dc.identifier.urihttp://hdl.handle.net/10722/175839-
dc.description.abstractPower calculation for QTL linkage analysis can be performed via simple algebraic formulas for small pedigrees, but requires intensive computation for large pedigrees, in order to evaluate the expectation of the test statistic over all possible inheritance vectors at the test position. In this report, we show that the non-centrality parameter for an arbitrary pedigree can be approximated by the sum of the variances of the correlations between all pairs of relatives, each variance being weighted by a factor that is determined by the mean correlation of the pair. We show that this approximation is sufficiently accurate for practical purposes in small to moderately large pedigrees, and that large sibships are more efficient than other family structures under a range of genetic models.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ejhgen_US
dc.relation.ispartofEuropean Journal of Human Geneticsen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPedigreeen_US
dc.subject.meshQuantitative Trait, Heritableen_US
dc.titleAnalytic power calculation for QTL linkage analysis of small pedigreesen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.ejhg.5200634en_US
dc.identifier.pmid11378821-
dc.identifier.scopuseid_2-s2.0-0034980335en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034980335&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume9en_US
dc.identifier.issue5en_US
dc.identifier.spage335en_US
dc.identifier.epage340en_US
dc.identifier.isiWOS:000168799000003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridRijsdijk, FV=6701830835en_US
dc.identifier.scopusauthoridHewitt, JK=7202713286en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US

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