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Article: Shifting paradigms in gene-mapping methodology for complex traits

TitleShifting paradigms in gene-mapping methodology for complex traits
Authors
Issue Date2001
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/pgs
Citation
Pharmacogenomics, 2001, v. 2 n. 3, p. 195-202 How to Cite?
AbstractThe analysis of genetic linkage has been highly successful in the mapping of the genes responsible for Mendelian diseases. In the past decade, attempts have been made to extend this approach to multifactorial disorders and other health-related traits. It has proved difficult, however, to obtain strong and replicable linkage findings for the common forms of heritable diseases. This, together with the rapid pace of development of molecular technology and expansion of genome sequence information, has resulted in significant shifts in research paradigm. There is an increasing recognition of the need to understand the population genetics and biometrical properties of clinically relevant traits so that phenotypes can be defined in such a way that maximises the chances of successful gene mapping. There is a trend towards systematic association analysis with increasing sophistication in the analysis of pooled DNA samples and multilocus haplotypes, and in the use of unlinked background markers to protect against spurious associations. We can expect increasing integration between genetics, epidemiology and clinical trials leading to genetically informative designs that will not only identify susceptibility genes but also clarify how the environment influences their effects and how they may modify the response to therapeutic interventions.
Persistent Identifierhttp://hdl.handle.net/10722/175833
ISSN
2015 Impact Factor: 2.71
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSham, Pen_US
dc.date.accessioned2012-11-26T09:01:40Z-
dc.date.available2012-11-26T09:01:40Z-
dc.date.issued2001en_US
dc.identifier.citationPharmacogenomics, 2001, v. 2 n. 3, p. 195-202en_US
dc.identifier.issn1462-2416en_US
dc.identifier.urihttp://hdl.handle.net/10722/175833-
dc.description.abstractThe analysis of genetic linkage has been highly successful in the mapping of the genes responsible for Mendelian diseases. In the past decade, attempts have been made to extend this approach to multifactorial disorders and other health-related traits. It has proved difficult, however, to obtain strong and replicable linkage findings for the common forms of heritable diseases. This, together with the rapid pace of development of molecular technology and expansion of genome sequence information, has resulted in significant shifts in research paradigm. There is an increasing recognition of the need to understand the population genetics and biometrical properties of clinically relevant traits so that phenotypes can be defined in such a way that maximises the chances of successful gene mapping. There is a trend towards systematic association analysis with increasing sophistication in the analysis of pooled DNA samples and multilocus haplotypes, and in the use of unlinked background markers to protect against spurious associations. We can expect increasing integration between genetics, epidemiology and clinical trials leading to genetically informative designs that will not only identify susceptibility genes but also clarify how the environment influences their effects and how they may modify the response to therapeutic interventions.en_US
dc.languageengen_US
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/pgsen_US
dc.relation.ispartofPharmacogenomicsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChromosome Mapping - Methodsen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenomicsen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshQuantitative Trait, Heritableen_US
dc.titleShifting paradigms in gene-mapping methodology for complex traitsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1517/14622416.2.3.195en_US
dc.identifier.pmid11535109-
dc.identifier.scopuseid_2-s2.0-0034846334en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034846334&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_US
dc.identifier.issue3en_US
dc.identifier.spage195en_US
dc.identifier.epage202en_US
dc.identifier.isiWOS:000172577300003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSham, P=34573429300en_US

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