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Article: Gallstone formation: Local factors

TitleGallstone formation: Local factors
Authors
Issue Date1999
PublisherWB Saunders Co. The Journal's web site is located at http://www.gastro.theclinics.com/
Citation
Gastroenterology Clinics Of North America, 1999, v. 28 n. 1, p. 99-115 How to Cite?
AbstractSupersaturation of bile is a necessary prerequisite to gallstone formation. However, patients who have undergone a cholecystectomy do not form gallstones. This indicates a role of local factors in gallstone formation. Gallbladder stasis, mucin secretion, the presence of pronucleating and antinucleating biliary proteins, and some medications have been shown to alter gallstone formation. New data has also caused the role of bacterial infection in gallstone pathogenesis to be re-examined. In addition, genetic factors have recently been identified which may predispose to gallstone formation by altering the secretion of hepatic bile.
Persistent Identifierhttp://hdl.handle.net/10722/175802
ISSN
2015 Impact Factor: 2.99
2015 SCImago Journal Rankings: 1.238
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKo, CWen_US
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:01:25Z-
dc.date.available2012-11-26T09:01:25Z-
dc.date.issued1999en_US
dc.identifier.citationGastroenterology Clinics Of North America, 1999, v. 28 n. 1, p. 99-115en_US
dc.identifier.issn0889-8553en_US
dc.identifier.urihttp://hdl.handle.net/10722/175802-
dc.description.abstractSupersaturation of bile is a necessary prerequisite to gallstone formation. However, patients who have undergone a cholecystectomy do not form gallstones. This indicates a role of local factors in gallstone formation. Gallbladder stasis, mucin secretion, the presence of pronucleating and antinucleating biliary proteins, and some medications have been shown to alter gallstone formation. New data has also caused the role of bacterial infection in gallstone pathogenesis to be re-examined. In addition, genetic factors have recently been identified which may predispose to gallstone formation by altering the secretion of hepatic bile.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.gastro.theclinics.com/en_US
dc.relation.ispartofGastroenterology Clinics of North Americaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApolipoproteins E - Geneticsen_US
dc.subject.meshCeftriaxone - Adverse Effectsen_US
dc.subject.meshCephalosporins - Adverse Effectsen_US
dc.subject.meshCholelithiasis - Etiology - Metabolismen_US
dc.subject.meshGastrointestinal Agents - Adverse Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshInfection - Complicationsen_US
dc.subject.meshMiceen_US
dc.subject.meshOctreotide - Adverse Effectsen_US
dc.subject.meshRisk Factorsen_US
dc.titleGallstone formation: Local factorsen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0889-8553(05)70045-5en_US
dc.identifier.pmid10198780-
dc.identifier.scopuseid_2-s2.0-0032908387en_US
dc.identifier.volume28en_US
dc.identifier.issue1en_US
dc.identifier.spage99en_US
dc.identifier.epage115en_US
dc.identifier.isiWOS:000079639700006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKo, CW=7202596492en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US

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