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Article: Association analysis between dopamine receptor genes and bipolar affective disorder

TitleAssociation analysis between dopamine receptor genes and bipolar affective disorder
Authors
Issue Date1999
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 1999, v. 86 n. 3, p. 193-201 How to Cite?
AbstractWe have performed a case-control analysis of dopamine D2-like receptor (DRD2, DRD3 and DRD4) gene polymorphisms in 118 Han Chinese cases with bipolar affective disorder and 196 control subjects, and replication analysis in 157 English cases and 143 control subjects. We found association between a functional DRD2 promoter variant (P=0.03 by allele) and the DRD2 taq1A polymorphism (P=0.001 by allele) in Chinese bipolar disorder patients. However, this finding was not replicated in the Caucasian subjects, indicating that the significant association we observed in the Chinese population is a false positive finding. An alternative explanation is that these polymorphisms are risk factors in Chinese but not Caucasian populations, a hypothesis which seems unlikely in view of the similarity of the clinical characteristics of bipolar disorder in the two populations. We also report a novel, rare one-repeat variant of the DRD4 exon 3 VNTR repeat in Chinese populations, which appears to be absent in Caucasians and is not associated with disease. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/175798
ISSN
2015 Impact Factor: 2.466
2015 SCImago Journal Rankings: 1.235
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorAitchison, KJen_US
dc.contributor.authorCai, Gen_US
dc.contributor.authorArranz, MJen_US
dc.contributor.authorDeng, Hen_US
dc.contributor.authorLiu, Jen_US
dc.contributor.authorKirov, Gen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:01:23Z-
dc.date.available2012-11-26T09:01:23Z-
dc.date.issued1999en_US
dc.identifier.citationPsychiatry Research, 1999, v. 86 n. 3, p. 193-201en_US
dc.identifier.issn0165-1781en_US
dc.identifier.urihttp://hdl.handle.net/10722/175798-
dc.description.abstractWe have performed a case-control analysis of dopamine D2-like receptor (DRD2, DRD3 and DRD4) gene polymorphisms in 118 Han Chinese cases with bipolar affective disorder and 196 control subjects, and replication analysis in 157 English cases and 143 control subjects. We found association between a functional DRD2 promoter variant (P=0.03 by allele) and the DRD2 taq1A polymorphism (P=0.001 by allele) in Chinese bipolar disorder patients. However, this finding was not replicated in the Caucasian subjects, indicating that the significant association we observed in the Chinese population is a false positive finding. An alternative explanation is that these polymorphisms are risk factors in Chinese but not Caucasian populations, a hypothesis which seems unlikely in view of the similarity of the clinical characteristics of bipolar disorder in the two populations. We also report a novel, rare one-repeat variant of the DRD4 exon 3 VNTR repeat in Chinese populations, which appears to be absent in Caucasians and is not associated with disease. Copyright (C) 1999 Elsevier Science Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresen_US
dc.relation.ispartofPsychiatry Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAllelesen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBipolar Disorder - Ethnology - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshReceptors, Dopamine D4en_US
dc.subject.meshRepetitive Sequences, Nucleic Acid - Geneticsen_US
dc.titleAssociation analysis between dopamine receptor genes and bipolar affective disorderen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-1781(99)00034-7en_US
dc.identifier.pmid10482338-
dc.identifier.scopuseid_2-s2.0-0032783522en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032783522&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume86en_US
dc.identifier.issue3en_US
dc.identifier.spage193en_US
dc.identifier.epage201en_US
dc.identifier.isiWOS:000082281600002-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridAitchison, KJ=7003415672en_US
dc.identifier.scopusauthoridCai, G=15134875600en_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridDeng, H=35204671600en_US
dc.identifier.scopusauthoridLiu, J=36072193800en_US
dc.identifier.scopusauthoridKirov, G=26643478800en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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