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Article: Meta-analysis of studies on genetic variation in 5-HT(2A) receptors and clozapine response

TitleMeta-analysis of studies on genetic variation in 5-HT(2A) receptors and clozapine response
Authors
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 1998, v. 32 n. 2, p. 93-99 How to Cite?
AbstractSerotonin (5-HT) neurotransmitter receptors are targeted by atypical antipsychotic drugs. We hypothesized that genetic variation in these receptors may affect clinical response to the drugs targeting them. This hypothesis has been tested by several studies in which the correlation between polymorphic variants in the 5-HT(2A) receptor gene and clinical response to the atypical antipsychotic clozapine was investigated. The results of these studies either found association between 5-HT(2A) genetic variants and clozapine response or found differences in the same direction which did not reach statistical significance. Meta-analysis of these studies including 373 patients who responded to the treatment and 360 non-responders showed association between two 5-HT(2A) polymorphisms, 102-T/C and His452Tyr, and clozapine response. Statistical analysis of extreme responders showed a clearer association of the 102-T/C with clozapine response. These results reinforce the hypothesis and strengthen the candidacy of these receptors as important therapeutic targets.
Persistent Identifierhttp://hdl.handle.net/10722/175795
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorArranz, MJen_US
dc.contributor.authorMunro, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKirov, Gen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorKerwin, RWen_US
dc.date.accessioned2012-11-26T09:01:21Z-
dc.date.available2012-11-26T09:01:21Z-
dc.date.issued1998en_US
dc.identifier.citationSchizophrenia Research, 1998, v. 32 n. 2, p. 93-99en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175795-
dc.description.abstractSerotonin (5-HT) neurotransmitter receptors are targeted by atypical antipsychotic drugs. We hypothesized that genetic variation in these receptors may affect clinical response to the drugs targeting them. This hypothesis has been tested by several studies in which the correlation between polymorphic variants in the 5-HT(2A) receptor gene and clinical response to the atypical antipsychotic clozapine was investigated. The results of these studies either found association between 5-HT(2A) genetic variants and clozapine response or found differences in the same direction which did not reach statistical significance. Meta-analysis of these studies including 373 patients who responded to the treatment and 360 non-responders showed association between two 5-HT(2A) polymorphisms, 102-T/C and His452Tyr, and clozapine response. Statistical analysis of extreme responders showed a clearer association of the 102-T/C with clozapine response. These results reinforce the hypothesis and strengthen the candidacy of these receptors as important therapeutic targets.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAllelesen_US
dc.subject.meshAntipsychotic Agents - Pharmacologyen_US
dc.subject.meshClozapine - Pharmacologyen_US
dc.subject.meshGenetic Variation - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptor, Serotonin, 5-Ht2aen_US
dc.subject.meshReceptors, Serotonin - Geneticsen_US
dc.titleMeta-analysis of studies on genetic variation in 5-HT(2A) receptors and clozapine responseen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(98)00032-2en_US
dc.identifier.pmid9713904-
dc.identifier.scopuseid_2-s2.0-0032572611en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032572611&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue2en_US
dc.identifier.spage93en_US
dc.identifier.epage99en_US
dc.identifier.isiWOS:000075204800004-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridMunro, J=7102726057en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKirov, G=26643478800en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridKerwin, RW=7102904567en_US

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