File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia

TitleTransmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia
Authors
Issue Date1998
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 1998, v. 251 n. 2, p. 662-665 How to Cite?
AbstracthKCa3 is a neuronal small conductance calcium-activated potassium channel which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of the CAG repeat and schizophrenia has been reported, we performed haplotype-based haplotype relative risk (HHRR) and transmission disequilibrium (TDT) in 97 family trios with schizophrenia from SW China. We found no evidence for an excess of longer CAG repeats in the patients, and the ETDT test was not significant for either allele-wise (P = 0.31) or genotype-wise analysis (P = 0.18). However, there was a deficit of transmission of the (CAG) 20 repeat allele to affected offspring when this allele was considered individually by TDT (P = 0.012; not corrected for multiple testing). These data do not support a role for larger alleles at the hKCa3 locus in psychosis in Chinese subjects.
Persistent Identifierhttp://hdl.handle.net/10722/175793
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorHu, Xen_US
dc.contributor.authorChandy, KGen_US
dc.contributor.authorFantino, Een_US
dc.contributor.authorKalman, Ken_US
dc.contributor.authorGutman, Gen_US
dc.contributor.authorGargus, JJen_US
dc.contributor.authorFreeman, Ben_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorDawson, Een_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorBruinvels, ATen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:01:20Z-
dc.date.available2012-11-26T09:01:20Z-
dc.date.issued1998en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 1998, v. 251 n. 2, p. 662-665en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/175793-
dc.description.abstracthKCa3 is a neuronal small conductance calcium-activated potassium channel which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of the CAG repeat and schizophrenia has been reported, we performed haplotype-based haplotype relative risk (HHRR) and transmission disequilibrium (TDT) in 97 family trios with schizophrenia from SW China. We found no evidence for an excess of longer CAG repeats in the patients, and the ETDT test was not significant for either allele-wise (P = 0.31) or genotype-wise analysis (P = 0.18). However, there was a deficit of transmission of the (CAG) 20 repeat allele to affected offspring when this allele was considered individually by TDT (P = 0.012; not corrected for multiple testing). These data do not support a role for larger alleles at the hKCa3 locus in psychosis in Chinese subjects.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAllelesen_US
dc.subject.meshChinaen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 1en_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPotassium Channels - Geneticsen_US
dc.subject.meshPotassium Channels, Calcium-Activateden_US
dc.subject.meshRisken_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshSmall-Conductance Calcium-Activated Potassium Channelsen_US
dc.subject.meshTrinucleotide Repeatsen_US
dc.titleTransmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/bbrc.1998.9484en_US
dc.identifier.pmid9792831-
dc.identifier.scopuseid_2-s2.0-0032552863en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032552863&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume251en_US
dc.identifier.issue2en_US
dc.identifier.spage662en_US
dc.identifier.epage665en_US
dc.identifier.isiWOS:000076638900046-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridHu, X=7404709241en_US
dc.identifier.scopusauthoridChandy, KG=7103379279en_US
dc.identifier.scopusauthoridFantino, E=16309753700en_US
dc.identifier.scopusauthoridKalman, K=7003665955en_US
dc.identifier.scopusauthoridGutman, G=7102122335en_US
dc.identifier.scopusauthoridGargus, JJ=35462660000en_US
dc.identifier.scopusauthoridFreeman, B=7202008351en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridDawson, E=7102147964en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridBruinvels, AT=6701557481en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats