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Article: Differences in distribution of ages of onset in males and females with schizophrenia

TitleDifferences in distribution of ages of onset in males and females with schizophrenia
Authors
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 1998, v. 33 n. 3, p. 179-183 How to Cite?
AbstractAn earlier age at onset of schizophrenia in men as opposed to women, has been widely reported, but hitherto, insufficient account has been taken of parameters that might confound this finding. Furthermore, few explanatory models have accounted for the differences in shape of the age-at-onset distributions in males and females with schizophrenia. A catchment area sample of 477 first contact cases with schizophrenia or related disorders was ascertained through a case register. Differences in age at onset distributions between males and females were determined, and adjustment made for potential confounding factors. The most powerful predictors of early illness-onset were poor premorbid occupational functioning, single marital status, and male sex. The earlier onset in males was robust to controlling for other parameters. The shape of the onset distribution also differed between the sexes: SKUMIX analysis revealed a two-peak distribution for males, and a three-peak distribution for females. The mean age at onset for schizophrenia is earlier in males, and the onset distribution differs between the sexes. Psychosocial variables cannot explain these findings. Possible explanations for these gender differences include males and females being differentially susceptible to subtypes of illness With different mean ages at onset; precipitating and/or ameliorating factors operating at different stages of life in males and females; and/or an X-linked susceptibility locus that determines the age at onset.
Persistent Identifierhttp://hdl.handle.net/10722/175791
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCastle, Den_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorMurray, Ren_US
dc.date.accessioned2012-11-26T09:01:19Z-
dc.date.available2012-11-26T09:01:19Z-
dc.date.issued1998en_US
dc.identifier.citationSchizophrenia Research, 1998, v. 33 n. 3, p. 179-183en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175791-
dc.description.abstractAn earlier age at onset of schizophrenia in men as opposed to women, has been widely reported, but hitherto, insufficient account has been taken of parameters that might confound this finding. Furthermore, few explanatory models have accounted for the differences in shape of the age-at-onset distributions in males and females with schizophrenia. A catchment area sample of 477 first contact cases with schizophrenia or related disorders was ascertained through a case register. Differences in age at onset distributions between males and females were determined, and adjustment made for potential confounding factors. The most powerful predictors of early illness-onset were poor premorbid occupational functioning, single marital status, and male sex. The earlier onset in males was robust to controlling for other parameters. The shape of the onset distribution also differed between the sexes: SKUMIX analysis revealed a two-peak distribution for males, and a three-peak distribution for females. The mean age at onset for schizophrenia is earlier in males, and the onset distribution differs between the sexes. Psychosocial variables cannot explain these findings. Possible explanations for these gender differences include males and females being differentially susceptible to subtypes of illness With different mean ages at onset; precipitating and/or ameliorating factors operating at different stages of life in males and females; and/or an X-linked susceptibility locus that determines the age at onset.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.subject.meshSchizotypal Personality Disorder - Diagnosis - Geneticsen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSocial Adjustmenten_US
dc.titleDifferences in distribution of ages of onset in males and females with schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(98)00070-Xen_US
dc.identifier.pmid9789910-
dc.identifier.scopuseid_2-s2.0-0032500693en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032500693&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue3en_US
dc.identifier.spage179en_US
dc.identifier.epage183en_US
dc.identifier.isiWOS:000076198000007-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridCastle, D=16149153500en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US

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