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Article: Risk factors for onset and persistence of psychosis

TitleRisk factors for onset and persistence of psychosis
Authors
Issue Date1998
PublisherSpringer Medizin. The Journal's web site is located at http://www.springer.com/steinkopff/psychiatrie/journal/127
Citation
Social Psychiatry And Psychiatric Epidemiology, 1998, v. 33 n. 12, p. 596-605 How to Cite?
AbstractClinical practice, training and evaluation of treatment in the functional psychoses continues to be carried out mostly along the traditional line of separation by diagnostic entity. However, the combined evidence from research on risk factors for onset and for persistence of psychotic illness indicates quantitative, but not qualitative, differences between categories of schizophrenia and affective psychosis. 'Developmental' factors, such as childhood dysfunction, increased cerebral ventricle size and familial morbid risk of schizophrenia operate preferentially, though not specifically, at that end of the psychopathological spectrum characterised by a preponderance of negative features. On the other hand, 'social' factors. such as ethnic group, adverse life events and familial morbid risk of affective disorder have a larger impact at the end associated with predominance of affective features. Heterogeneity in the functional psychoses may thus be best conceived as two discrete effects operating at different ends of a continuous psychopathological spectrum. The use of highly reliable but arbitrary diagnostic categories may introduce serious bias in aetiological and treatment research. Evidence supporting the validity of a model of shared risk factors for continuous characteristics needs to be further elaborated and incorporated into our concepts of psychotic illness.
Persistent Identifierhttp://hdl.handle.net/10722/175780
ISSN
2015 Impact Factor: 2.513
2015 SCImago Journal Rankings: 1.095
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVan Os, Jen_US
dc.contributor.authorJones, Pen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorBebbington, Pen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:01:14Z-
dc.date.available2012-11-26T09:01:14Z-
dc.date.issued1998en_US
dc.identifier.citationSocial Psychiatry And Psychiatric Epidemiology, 1998, v. 33 n. 12, p. 596-605en_US
dc.identifier.issn0933-7954en_US
dc.identifier.urihttp://hdl.handle.net/10722/175780-
dc.description.abstractClinical practice, training and evaluation of treatment in the functional psychoses continues to be carried out mostly along the traditional line of separation by diagnostic entity. However, the combined evidence from research on risk factors for onset and for persistence of psychotic illness indicates quantitative, but not qualitative, differences between categories of schizophrenia and affective psychosis. 'Developmental' factors, such as childhood dysfunction, increased cerebral ventricle size and familial morbid risk of schizophrenia operate preferentially, though not specifically, at that end of the psychopathological spectrum characterised by a preponderance of negative features. On the other hand, 'social' factors. such as ethnic group, adverse life events and familial morbid risk of affective disorder have a larger impact at the end associated with predominance of affective features. Heterogeneity in the functional psychoses may thus be best conceived as two discrete effects operating at different ends of a continuous psychopathological spectrum. The use of highly reliable but arbitrary diagnostic categories may introduce serious bias in aetiological and treatment research. Evidence supporting the validity of a model of shared risk factors for continuous characteristics needs to be further elaborated and incorporated into our concepts of psychotic illness.en_US
dc.languageengen_US
dc.publisherSpringer Medizin. The Journal's web site is located at http://www.springer.com/steinkopff/psychiatrie/journal/127en_US
dc.relation.ispartofSocial Psychiatry and Psychiatric Epidemiologyen_US
dc.subject.meshAffective Disorders, Psychotic - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshChild Of Impaired Parents - Psychologyen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.subject.meshSocial Environmenten_US
dc.titleRisk factors for onset and persistence of psychosisen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s001270050099en_US
dc.identifier.pmid9857792-
dc.identifier.scopuseid_2-s2.0-0031735208en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031735208&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue12en_US
dc.identifier.spage596en_US
dc.identifier.epage605en_US
dc.identifier.isiWOS:000077323100004-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridVan Os, J=7102358027en_US
dc.identifier.scopusauthoridJones, P=36078972900en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridBebbington, P=7102209922en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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