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Article: Acute pancreatitis in marrow transplant patients: Prevalence at autopsy and risk factor analysis

TitleAcute pancreatitis in marrow transplant patients: Prevalence at autopsy and risk factor analysis
Authors
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 1997, v. 20 n. 12, p. 1081-1086 How to Cite?
AbstractPancreatitis has been described as an infrequent complication of marrow transplantation. This study investigated the prevalence of pancreatitis at autopsy in marrow transplant patients and determined risk factors for its development. We reviewed consecutive autopsy reports from 1991 to 1993. Medical records and laboratory reports were reviewed for analysis of clinical variables. Autopsy findings and clinical variables were correlated with the autopsy diagnosis of pancreatitis. Pancreatitis was found in 51 of 184 (28%) patients at autopsy. Of those with pancreatitis, 35% had abdominal pain, 10% had measurements of serum pancreatic enzymes, and 20% had abdominal imaging studies in the week prior to death. By univariable analysis, risk factors associated with development of pancreatitis included clinical grades 3 and 4 GVHD, GVHD at autopsy, liver GVHD at autopsy, major infection at autopsy, and increasing days of survival.By multivariable analysis, independent risk factors for its development included any GVHD at autopsy, increasing length of survival after transplantation, and major infection at autopsy. We conclude that pancreatitis is a common but often subclinical complication of marrow transplantation. Its development may be associated with a high prevalence of biliary sludge and prolonged treatment of GVHD with cyclosporine and prednisone.
Persistent Identifierhttp://hdl.handle.net/10722/175778
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKo, CWen_US
dc.contributor.authorGooley, Ten_US
dc.contributor.authorSchoch, HGen_US
dc.contributor.authorMyerson, Den_US
dc.contributor.authorHackman, RCen_US
dc.contributor.authorShulman, HMen_US
dc.contributor.authorSale, GEen_US
dc.contributor.authorLee, SPen_US
dc.contributor.authorMcdonald, GBen_US
dc.date.accessioned2012-11-26T09:01:14Z-
dc.date.available2012-11-26T09:01:14Z-
dc.date.issued1997en_US
dc.identifier.citationBone Marrow Transplantation, 1997, v. 20 n. 12, p. 1081-1086en_US
dc.identifier.issn0268-3369en_US
dc.identifier.urihttp://hdl.handle.net/10722/175778-
dc.description.abstractPancreatitis has been described as an infrequent complication of marrow transplantation. This study investigated the prevalence of pancreatitis at autopsy in marrow transplant patients and determined risk factors for its development. We reviewed consecutive autopsy reports from 1991 to 1993. Medical records and laboratory reports were reviewed for analysis of clinical variables. Autopsy findings and clinical variables were correlated with the autopsy diagnosis of pancreatitis. Pancreatitis was found in 51 of 184 (28%) patients at autopsy. Of those with pancreatitis, 35% had abdominal pain, 10% had measurements of serum pancreatic enzymes, and 20% had abdominal imaging studies in the week prior to death. By univariable analysis, risk factors associated with development of pancreatitis included clinical grades 3 and 4 GVHD, GVHD at autopsy, liver GVHD at autopsy, major infection at autopsy, and increasing days of survival.By multivariable analysis, independent risk factors for its development included any GVHD at autopsy, increasing length of survival after transplantation, and major infection at autopsy. We conclude that pancreatitis is a common but often subclinical complication of marrow transplantation. Its development may be associated with a high prevalence of biliary sludge and prolonged treatment of GVHD with cyclosporine and prednisone.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_US
dc.relation.ispartofBone Marrow Transplantationen_US
dc.subject.meshAbdominal Pain - Epidemiology - Etiologyen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAmylases - Blooden_US
dc.subject.meshBile - Chemistryen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshBone Marrow Transplantation - Adverse Effects - Mortalityen_US
dc.subject.meshCause Of Deathen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshCyclosporine - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallbladder - Pathologyen_US
dc.subject.meshGraft Vs Host Disease - Complications - Mortalityen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agents - Adverse Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMethotrexate - Administration & Dosageen_US
dc.subject.meshNeoplasms - Complications - Therapyen_US
dc.subject.meshPancreatitis - Epidemiology - Etiologyen_US
dc.subject.meshPrednisone - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTransplantation Conditioning - Adverse Effectsen_US
dc.subject.meshWhole-Body Irradiation - Adverse Effectsen_US
dc.titleAcute pancreatitis in marrow transplant patients: Prevalence at autopsy and risk factor analysisen_US
dc.typeArticleen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.bmt.1701024-
dc.identifier.pmid9466282-
dc.identifier.scopuseid_2-s2.0-0031439031en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031439031&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue12en_US
dc.identifier.spage1081en_US
dc.identifier.epage1086en_US
dc.identifier.isiWOS:000071564700011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKo, CW=7202596492en_US
dc.identifier.scopusauthoridGooley, T=7005558173en_US
dc.identifier.scopusauthoridSchoch, HG=6701848879en_US
dc.identifier.scopusauthoridMyerson, D=35407803300en_US
dc.identifier.scopusauthoridHackman, RC=7006585980en_US
dc.identifier.scopusauthoridShulman, HM=35393142800en_US
dc.identifier.scopusauthoridSale, GE=7005901933en_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US
dc.identifier.scopusauthoridMcDonald, GB=7203029062en_US

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