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Article: Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations

TitleSuggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations
Authors
Issue Date1997
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00439/index.htm
Citation
Human Genetics, 1997, v. 99 n. 3, p. 417-420 How to Cite?
AbstractPreviously we reported suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. We have now studied an additional independent sample of 44 pedigrees consisting of 34 Taiwanese, 9 English and 1 Welsh family in an attempt to replicate this finding. Narrow and broad models based on Research Diagnostic Criteria or the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised, were used to define the schizophrenia phenotype. Under a dominant genetic model, two-point 1od scores obtained for most of the markers were negative except that marker D13S122 gave a total 1od score of 1.06 (θ = 0.2, broad model). As combining pedigrees from different ethnic origins may be inappropriate, we combined this replication sample and our original sample, and then divided the total sample into Caucasian (English and Welsh pedigrees) and Oriental (Taiwanese and Japanese pedigrees) groups. The Caucasian pedigrees produced maximized admixture two-point lod scores (A-1od) of 1.41 for the marker D13S119 (θ = 0.2, α = 1.0) and 1.54 for D13S128 (θ = 0, α = 0.3) with nearby markers also producing positive A-led scores. When five-point model-free linkage analysis was applied to the Caucasian sample, a maximum 1od score of 2.58 was obtained around the markers D13S122 and D13S128, which are located on chromosome 13q32. The linkage results for the Oriental group were less positive than the Caucasian group. Our results again suggest that there is a potential susceptibility locus for schizophrenia on chromosome 13q14.1-q32, especially in the Caucasian population.
Persistent Identifierhttp://hdl.handle.net/10722/175775
ISSN
2015 Impact Factor: 5.138
2015 SCImago Journal Rankings: 2.931
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, MWen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorHwu, HGen_US
dc.contributor.authorCollier, Den_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorPowell, JFen_US
dc.date.accessioned2012-11-26T09:01:12Z-
dc.date.available2012-11-26T09:01:12Z-
dc.date.issued1997en_US
dc.identifier.citationHuman Genetics, 1997, v. 99 n. 3, p. 417-420en_US
dc.identifier.issn0340-6717en_US
dc.identifier.urihttp://hdl.handle.net/10722/175775-
dc.description.abstractPreviously we reported suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. We have now studied an additional independent sample of 44 pedigrees consisting of 34 Taiwanese, 9 English and 1 Welsh family in an attempt to replicate this finding. Narrow and broad models based on Research Diagnostic Criteria or the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised, were used to define the schizophrenia phenotype. Under a dominant genetic model, two-point 1od scores obtained for most of the markers were negative except that marker D13S122 gave a total 1od score of 1.06 (θ = 0.2, broad model). As combining pedigrees from different ethnic origins may be inappropriate, we combined this replication sample and our original sample, and then divided the total sample into Caucasian (English and Welsh pedigrees) and Oriental (Taiwanese and Japanese pedigrees) groups. The Caucasian pedigrees produced maximized admixture two-point lod scores (A-1od) of 1.41 for the marker D13S119 (θ = 0.2, α = 1.0) and 1.54 for D13S128 (θ = 0, α = 0.3) with nearby markers also producing positive A-led scores. When five-point model-free linkage analysis was applied to the Caucasian sample, a maximum 1od score of 2.58 was obtained around the markers D13S122 and D13S128, which are located on chromosome 13q32. The linkage results for the Oriental group were less positive than the Caucasian group. Our results again suggest that there is a potential susceptibility locus for schizophrenia on chromosome 13q14.1-q32, especially in the Caucasian population.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00439/index.htmen_US
dc.relation.ispartofHuman Geneticsen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 13en_US
dc.subject.meshEnglanden_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshHumansen_US
dc.subject.meshLod Scoreen_US
dc.subject.meshMicrosatellite Repeatsen_US
dc.subject.meshSchizophrenia - Ethnology - Geneticsen_US
dc.subject.meshTaiwanen_US
dc.subject.meshWalesen_US
dc.titleSuggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populationsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s004390050382en_US
dc.identifier.pmid9050933-
dc.identifier.scopuseid_2-s2.0-0031058747en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031058747&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume99en_US
dc.identifier.issue3en_US
dc.identifier.spage417en_US
dc.identifier.epage420en_US
dc.identifier.isiWOS:A1997WM46800024-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridLin, MW=35277520300en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridHwu, HG=7006444908en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridPowell, JF=7403541196en_US

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