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Article: A controlled family study of late-onset non-affective psychosis (late paraphrenia)

TitleA controlled family study of late-onset non-affective psychosis (late paraphrenia)
Authors
Issue Date1997
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 1997, v. 170 JUNE, p. 511-514 How to Cite?
AbstractBackground: The relationship between those schizophrenia-like conditions that have their onset in late life and early-onset schizophrenia is unclear. Very few family history studies of patients with late-onset psychosis have been reported, and it is not known whether their relatives have an increased risk of psychosis. Method: Information was collected on the psychiatric morbidity of 269 firstdegree relatives of patients with schizophrenia or delusional disorder with an onset after the age of 60 (late paraphrenia), and 272 first-degree relatives of healthy elderly control subjects, using a research diagnostic instrument. Results: With a narrow age range (15-50 years) at risk, the estimated lifetime risk of schizophrenia was 1.3% in the relatives of both cases and controls. With a wider age range (15-90 years) at risk, estimated lifetime risk of schizophrenia was 2.3% for the relatives of cases, and 2.2% for the relatives of controls. However, depression was significantly more common among the relatives of cases than controls. Conclusion: Those schizophrenia-like psychoses with onset in late life are not genetically associated with schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/175769
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHoward, RJen_US
dc.contributor.authorGraham, Cen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorDennehey, Jen_US
dc.contributor.authorCastle, DJen_US
dc.contributor.authorLevy, Ren_US
dc.contributor.authorMurray, Ren_US
dc.date.accessioned2012-11-26T09:01:10Z-
dc.date.available2012-11-26T09:01:10Z-
dc.date.issued1997en_US
dc.identifier.citationBritish Journal Of Psychiatry, 1997, v. 170 JUNE, p. 511-514en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175769-
dc.description.abstractBackground: The relationship between those schizophrenia-like conditions that have their onset in late life and early-onset schizophrenia is unclear. Very few family history studies of patients with late-onset psychosis have been reported, and it is not known whether their relatives have an increased risk of psychosis. Method: Information was collected on the psychiatric morbidity of 269 firstdegree relatives of patients with schizophrenia or delusional disorder with an onset after the age of 60 (late paraphrenia), and 272 first-degree relatives of healthy elderly control subjects, using a research diagnostic instrument. Results: With a narrow age range (15-50 years) at risk, the estimated lifetime risk of schizophrenia was 1.3% in the relatives of both cases and controls. With a wider age range (15-90 years) at risk, estimated lifetime risk of schizophrenia was 2.3% for the relatives of cases, and 2.2% for the relatives of controls. However, depression was significantly more common among the relatives of cases than controls. Conclusion: Those schizophrenia-like psychoses with onset in late life are not genetically associated with schizophrenia.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Of Onseten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshDelusions - Etiologyen_US
dc.subject.meshFamily Healthen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPedigreeen_US
dc.subject.meshPsychotic Disorders - Etiologyen_US
dc.subject.meshSchizophrenia - Etiologyen_US
dc.titleA controlled family study of late-onset non-affective psychosis (late paraphrenia)en_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.170.6.511-
dc.identifier.pmid9330015-
dc.identifier.scopuseid_2-s2.0-0030833283en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030833283&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume170en_US
dc.identifier.issueJUNEen_US
dc.identifier.spage511en_US
dc.identifier.epage514en_US
dc.identifier.isiWOS:A1997XE60200006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHoward, RJ=34769841900en_US
dc.identifier.scopusauthoridGraham, C=7401505162en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridDennehey, J=6505761355en_US
dc.identifier.scopusauthoridCastle, DJ=16149153500en_US
dc.identifier.scopusauthoridLevy, R=7404060972en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US

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