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Article: Analysis of a structural polymorphism in the 5-HT(2A) receptor and clinical response to clozapine

TitleAnalysis of a structural polymorphism in the 5-HT(2A) receptor and clinical response to clozapine
Authors
Issue Date1996
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1996, v. 217 n. 2-3, p. 177-178 How to Cite?
AbstractClozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr polymorphism in the 5-HT(2A) receptor (HTR2A) in a sample of 153 schizophrenic patients undergoing clozapine treatment and 178 normal controls. An association was found between the allele Tyr452 and poor clinical response.
Persistent Identifierhttp://hdl.handle.net/10722/175766
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorArranz, MJen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorMunro, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKirov, Gen_US
dc.contributor.authorSodhi, Men_US
dc.contributor.authorRoberts, Gen_US
dc.contributor.authorPrice, Jen_US
dc.contributor.authorKerwin, RWen_US
dc.date.accessioned2012-11-26T09:01:08Z-
dc.date.available2012-11-26T09:01:08Z-
dc.date.issued1996en_US
dc.identifier.citationNeuroscience Letters, 1996, v. 217 n. 2-3, p. 177-178en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/175766-
dc.description.abstractClozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr polymorphism in the 5-HT(2A) receptor (HTR2A) in a sample of 153 schizophrenic patients undergoing clozapine treatment and 178 normal controls. An association was found between the allele Tyr452 and poor clinical response.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAllelesen_US
dc.subject.meshAntipsychotic Agents - Pharmacology - Therapeutic Useen_US
dc.subject.meshClozapine - Pharmacology - Therapeutic Useen_US
dc.subject.meshDna - Analysisen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshReceptors, Serotonin - Geneticsen_US
dc.subject.meshSchizophrenia - Drug Therapy - Geneticsen_US
dc.titleAnalysis of a structural polymorphism in the 5-HT(2A) receptor and clinical response to clozapineen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0304-3940(96)13094-9en_US
dc.identifier.pmid8916101-
dc.identifier.scopuseid_2-s2.0-0030592571en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030592571&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume217en_US
dc.identifier.issue2-3en_US
dc.identifier.spage177en_US
dc.identifier.epage178en_US
dc.identifier.isiWOS:A1996VQ39800027-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridMunro, J=7102726057en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKirov, G=26643478800en_US
dc.identifier.scopusauthoridSodhi, M=7004463507en_US
dc.identifier.scopusauthoridRoberts, G=7403400681en_US
dc.identifier.scopusauthoridPrice, J=7404020184en_US
dc.identifier.scopusauthoridKerwin, RW=7102904567en_US

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