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Article: Autoimmune diseases in the pedigrees of schizophrenic and control subjects

TitleAutoimmune diseases in the pedigrees of schizophrenic and control subjects
Authors
Issue Date1996
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 1996, v. 20 n. 3, p. 261-267 How to Cite?
AbstractAutoimmune diseases aggregate in individuals and within pedigrees, and it has been postulated that autoimmune mechanisms may account for a proportion of schizophrenia. Structured questionnaires were used to interview the mothers of 121 DSM-III-R schizophrenic patients and the mothers of 116 controls in order to determine the prevalence of schizophrenia and of autoimmune diseases in their pedigrees. Patients with a schizophrenic first degree relative were significantly more likely to also have a parent or sibling with an autoimmune disease (60% vs. 20%, OR = 6.1, 95% CI = 2.3-16.5, p = 0.0003). A significant excess of insulin dependent diabetes mellitus (IDDM) was present in the parents and siblings of schizophrenic patients (OR = 9.65, 95% CI = 1.3-429.2, p = 0.009). These findings suggest that autoimmune mechanisms may play a role in the aetiology of schizophrenia, particularly familial schizophrenia. Associations have been established between autoimmune diseases and the HLA encoding genes of the major histocompatibility complex on chromosome six, and it may be that some of the genetic liability to schizophrenia involves these genes.
Persistent Identifierhttp://hdl.handle.net/10722/175765
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWright, Pen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorGilvarry, CMen_US
dc.contributor.authorJones, PBen_US
dc.contributor.authorCannon, Men_US
dc.contributor.authorSharma, Ten_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:01:07Z-
dc.date.available2012-11-26T09:01:07Z-
dc.date.issued1996en_US
dc.identifier.citationSchizophrenia Research, 1996, v. 20 n. 3, p. 261-267en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175765-
dc.description.abstractAutoimmune diseases aggregate in individuals and within pedigrees, and it has been postulated that autoimmune mechanisms may account for a proportion of schizophrenia. Structured questionnaires were used to interview the mothers of 121 DSM-III-R schizophrenic patients and the mothers of 116 controls in order to determine the prevalence of schizophrenia and of autoimmune diseases in their pedigrees. Patients with a schizophrenic first degree relative were significantly more likely to also have a parent or sibling with an autoimmune disease (60% vs. 20%, OR = 6.1, 95% CI = 2.3-16.5, p = 0.0003). A significant excess of insulin dependent diabetes mellitus (IDDM) was present in the parents and siblings of schizophrenic patients (OR = 9.65, 95% CI = 1.3-429.2, p = 0.009). These findings suggest that autoimmune mechanisms may play a role in the aetiology of schizophrenia, particularly familial schizophrenia. Associations have been established between autoimmune diseases and the HLA encoding genes of the major histocompatibility complex on chromosome six, and it may be that some of the genetic liability to schizophrenia involves these genes.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAutoimmune Diseases - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshDelirium, Dementia, Amnestic, Cognitive Disorders - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHla Antigens - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMajor Histocompatibility Complex - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.titleAutoimmune diseases in the pedigrees of schizophrenic and control subjectsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0920-9964(96)82950-1en_US
dc.identifier.pmid8827852-
dc.identifier.scopuseid_2-s2.0-0030570533en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030570533&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue3en_US
dc.identifier.spage261en_US
dc.identifier.epage267en_US
dc.identifier.isiWOS:A1996UY31900003-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridWright, P=7404316244en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridGilvarry, CM=6701857173en_US
dc.identifier.scopusauthoridJones, PB=36078972900en_US
dc.identifier.scopusauthoridCannon, M=7202419754en_US
dc.identifier.scopusauthoridSharma, T=7202571892en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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