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Article: Relationship between in utero exposure to influenza epidemics and risk of schizophrenia in Denmark

TitleRelationship between in utero exposure to influenza epidemics and risk of schizophrenia in Denmark
Authors
Issue Date1996
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 1996, v. 40 n. 9, p. 817-824 How to Cite?
AbstractSeveral recent epidemiological studies suggest that exposure to influenza during gestation increases the risk of later developing schizophrenia. Inconsistency exists, however, particularly in studies that have examined the relationship between the prevalence of influenza and the monthly number of schizophrenic births, over many years. Our sample (N = 9462) was obtained from a Danish computerized case register, and consisted of schizophrenic patients born between 1915 and 1970, and first admitted to Danish psychiatric hospitals between 1971 and 1991. The study sample was chosen to represent 'incidence cases' to allow us to calculate the population attributable risk fraction (PAF). The temporal correlation of fluctuations in the prevalence of influenza and fluctuations in the monthly number of preschizophrenic births was examined using a Poisson regression analysis. Exposure to influenza 4 months prior to birth (i.e., about the 6th month of gestation) was significantly associated with an increased risk of later schizophrenia, especially for narrowly defined schizophrenia. The number of schizophrenic births was found to have risen by 12% (95% confidence interval: 1-24%) for every 100,000 cases of influenza in the 4th month before birth. Our model indicates the PAF to be 1.4%, that is, only 1.4% of the whole schizophrenic sample is attributed to prenatal exposure to influenza. Although maternal exposure to influenza during midgestation is not a major risk factor for schizophrenia, the elucidation of its causal mechanism may open the avenue to understanding the neurodevelopmental origins of the disease.
Persistent Identifierhttp://hdl.handle.net/10722/175763
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTakei, Nen_US
dc.contributor.authorMortensen, PBen_US
dc.contributor.authorKlæning, Uen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorO'callaghan, Een_US
dc.contributor.authorMunkJørgensen, Pen_US
dc.date.accessioned2012-11-26T09:01:05Z-
dc.date.available2012-11-26T09:01:05Z-
dc.date.issued1996en_US
dc.identifier.citationBiological Psychiatry, 1996, v. 40 n. 9, p. 817-824en_US
dc.identifier.issn0006-3223en_US
dc.identifier.urihttp://hdl.handle.net/10722/175763-
dc.description.abstractSeveral recent epidemiological studies suggest that exposure to influenza during gestation increases the risk of later developing schizophrenia. Inconsistency exists, however, particularly in studies that have examined the relationship between the prevalence of influenza and the monthly number of schizophrenic births, over many years. Our sample (N = 9462) was obtained from a Danish computerized case register, and consisted of schizophrenic patients born between 1915 and 1970, and first admitted to Danish psychiatric hospitals between 1971 and 1991. The study sample was chosen to represent 'incidence cases' to allow us to calculate the population attributable risk fraction (PAF). The temporal correlation of fluctuations in the prevalence of influenza and fluctuations in the monthly number of preschizophrenic births was examined using a Poisson regression analysis. Exposure to influenza 4 months prior to birth (i.e., about the 6th month of gestation) was significantly associated with an increased risk of later schizophrenia, especially for narrowly defined schizophrenia. The number of schizophrenic births was found to have risen by 12% (95% confidence interval: 1-24%) for every 100,000 cases of influenza in the 4th month before birth. Our model indicates the PAF to be 1.4%, that is, only 1.4% of the whole schizophrenic sample is attributed to prenatal exposure to influenza. Although maternal exposure to influenza during midgestation is not a major risk factor for schizophrenia, the elucidation of its causal mechanism may open the avenue to understanding the neurodevelopmental origins of the disease.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_US
dc.relation.ispartofBiological Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDenmark - Epidemiologyen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfluenza, Human - Epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPoisson Distributionen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Infectious - Epidemiologyen_US
dc.subject.meshPrenatal Exposure Delayed Effectsen_US
dc.subject.meshRegistries - Statistics & Numerical Dataen_US
dc.subject.meshRisken_US
dc.subject.meshSchizophrenia - Epidemiology - Etiologyen_US
dc.subject.meshSeasonsen_US
dc.titleRelationship between in utero exposure to influenza epidemics and risk of schizophrenia in Denmarken_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0006-3223(95)00592-7en_US
dc.identifier.pmid8896767-
dc.identifier.scopuseid_2-s2.0-0030298574en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030298574&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume40en_US
dc.identifier.issue9en_US
dc.identifier.spage817en_US
dc.identifier.epage824en_US
dc.identifier.isiWOS:A1996VM69400001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTakei, N=35874982900en_US
dc.identifier.scopusauthoridMortensen, PB=7102903327en_US
dc.identifier.scopusauthoridKlæning, U=6503937947en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridO'Callaghan, E=7005694363en_US
dc.identifier.scopusauthoridMunkJørgensen, P=7005457037en_US

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