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Article: Assessing the statistical power to detect linkage in a sample of 51 bipolar affective disorder pedigrees

TitleAssessing the statistical power to detect linkage in a sample of 51 bipolar affective disorder pedigrees
Authors
Issue Date1996
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244
Citation
Behavior Genetics, 1996, v. 26 n. 2, p. 113-122 How to Cite?
AbstractWe used computer simulation method to address the question of power in an initial collaborative sample of 51 bipolar affective disorder pedigrees. Simulations were performed for all possible combinations using (1) two levels of diagnostic stringency, (2) three transmission models, (3) locus heterogeneity, and (4) different assumed phenocopy rates. Some of the factors that affect the power to detect linkage are (1) the specification of the correct genetic model, (2) the degree of locus heterogeneity, and (3) the frequency of phenocopies. The first two assertions were supported by our simulation results, but varying the rates of phenocopy did not substantially alter the power of the sample until a critical point. However, it is important to point out that these results are dependent on the genetic models under study and on the use of the 'correct' model (i.e., the one used to simulate the data). If we assume a dominant mode of inheritance and locus homogeneity, the power to detect linkage is 97.5% at a θ of .01. However, the power declines dramatically, to 60.5 and 14.7%, if only 75 and 50% of the families are linked, respectively. Locus heterogeneity has a similar effect on the power of the sample to exclude linkage. The relative lack of power in our data, in the presence of significant locus heterogeneity, and for an intermediate mode of inheritance, underscores the need for multicenter collaboration.
Persistent Identifierhttp://hdl.handle.net/10722/175755
ISSN
2015 Impact Factor: 3.268
2015 SCImago Journal Rankings: 1.457
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLim, LCCen_US
dc.contributor.authorCraddock, Nen_US
dc.contributor.authorOwen, Men_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorNöthen, MMen_US
dc.contributor.authorKörner, Jen_US
dc.contributor.authorRietschel, Men_US
dc.contributor.authorFimmer, Ren_US
dc.contributor.authorPropping, Pen_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorMurray, Ren_US
dc.contributor.authorGill, Men_US
dc.date.accessioned2012-11-26T09:01:01Z-
dc.date.available2012-11-26T09:01:01Z-
dc.date.issued1996en_US
dc.identifier.citationBehavior Genetics, 1996, v. 26 n. 2, p. 113-122en_US
dc.identifier.issn0001-8244en_US
dc.identifier.urihttp://hdl.handle.net/10722/175755-
dc.description.abstractWe used computer simulation method to address the question of power in an initial collaborative sample of 51 bipolar affective disorder pedigrees. Simulations were performed for all possible combinations using (1) two levels of diagnostic stringency, (2) three transmission models, (3) locus heterogeneity, and (4) different assumed phenocopy rates. Some of the factors that affect the power to detect linkage are (1) the specification of the correct genetic model, (2) the degree of locus heterogeneity, and (3) the frequency of phenocopies. The first two assertions were supported by our simulation results, but varying the rates of phenocopy did not substantially alter the power of the sample until a critical point. However, it is important to point out that these results are dependent on the genetic models under study and on the use of the 'correct' model (i.e., the one used to simulate the data). If we assume a dominant mode of inheritance and locus homogeneity, the power to detect linkage is 97.5% at a θ of .01. However, the power declines dramatically, to 60.5 and 14.7%, if only 75 and 50% of the families are linked, respectively. Locus heterogeneity has a similar effect on the power of the sample to exclude linkage. The relative lack of power in our data, in the presence of significant locus heterogeneity, and for an intermediate mode of inheritance, underscores the need for multicenter collaboration.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244en_US
dc.relation.ispartofBehavior Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBipolar Disorder - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequency - Geneticsen_US
dc.subject.meshGenes, Dominant - Geneticsen_US
dc.subject.meshGenetic Linkage - Geneticsen_US
dc.subject.meshHeterozygote Detectionen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshRisken_US
dc.titleAssessing the statistical power to detect linkage in a sample of 51 bipolar affective disorder pedigreesen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02359889en_US
dc.identifier.pmid8639147-
dc.identifier.scopuseid_2-s2.0-0030012006en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030012006&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue2en_US
dc.identifier.spage113en_US
dc.identifier.epage122en_US
dc.identifier.isiWOS:A1996UE22600004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLim, LCC=36484937000en_US
dc.identifier.scopusauthoridCraddock, N=35352014300en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridNöthen, MM=35355123900en_US
dc.identifier.scopusauthoridKörner, J=7102394501en_US
dc.identifier.scopusauthoridRietschel, M=7006620620en_US
dc.identifier.scopusauthoridFimmer, R=36484455500en_US
dc.identifier.scopusauthoridPropping, P=35355673000en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridMurray, R=35406239400en_US
dc.identifier.scopusauthoridGill, M=14633481100en_US

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