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Article: Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia

TitleAllelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia
Authors
Issue Date1996
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00439/index.htm
Citation
Human Genetics, 1996, v. 97 n. 6, p. 714-719 How to Cite?
AbstractWe examined a Ser-9-Gly polymorphism in the dopamine D3 receptor gene for allelic association with schizophrenia in 133 patients currently treated with clozapine and 109 controls. Allele 1 (Ser-9) was significantly more frequent in the patients (69%) than in the controls (56%) (P = 0.004). The 1-1 genotype was more common (43% vs 30%) and the 2-2 genotype less common (5% vs 18%) in patients than in controls. When the patient group was subdivided on the basis of clinical response to clozapine, using a 20-point improvement in the global assessment scale as cut-off, genotype 1-1 was found to be more frequent among the non-responders (53% vs 36%, P = 0.04). To place our results in the context of previous studies of this polymorphism and schizophrenia, we performed a meta-analysis of all published data including the present sample. The combined analysis shows evidence for a modest association between genotype 1-1 and schizophrenia (odds ratio 1.25, 95% confidence interval 1.05-1.49, P = 0.01). These results suggest that the Ser-9 allele, or a nearby polymorphism in linkage disequilibrium, results in a small increase in susceptibility to schizophrenia.
Persistent Identifierhttp://hdl.handle.net/10722/175754
ISSN
2015 Impact Factor: 5.138
2015 SCImago Journal Rankings: 2.931
References

 

DC FieldValueLanguage
dc.contributor.authorShaikh, Sen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorBall, Den_US
dc.contributor.authorAitchison, Ken_US
dc.contributor.authorVallada, Hen_US
dc.contributor.authorSmith, Ien_US
dc.contributor.authorGill, Men_US
dc.contributor.authorKerwin, RWen_US
dc.date.accessioned2012-11-26T09:01:00Z-
dc.date.available2012-11-26T09:01:00Z-
dc.date.issued1996en_US
dc.identifier.citationHuman Genetics, 1996, v. 97 n. 6, p. 714-719en_US
dc.identifier.issn0340-6717en_US
dc.identifier.urihttp://hdl.handle.net/10722/175754-
dc.description.abstractWe examined a Ser-9-Gly polymorphism in the dopamine D3 receptor gene for allelic association with schizophrenia in 133 patients currently treated with clozapine and 109 controls. Allele 1 (Ser-9) was significantly more frequent in the patients (69%) than in the controls (56%) (P = 0.004). The 1-1 genotype was more common (43% vs 30%) and the 2-2 genotype less common (5% vs 18%) in patients than in controls. When the patient group was subdivided on the basis of clinical response to clozapine, using a 20-point improvement in the global assessment scale as cut-off, genotype 1-1 was found to be more frequent among the non-responders (53% vs 36%, P = 0.04). To place our results in the context of previous studies of this polymorphism and schizophrenia, we performed a meta-analysis of all published data including the present sample. The combined analysis shows evidence for a modest association between genotype 1-1 and schizophrenia (odds ratio 1.25, 95% confidence interval 1.05-1.49, P = 0.01). These results suggest that the Ser-9 allele, or a nearby polymorphism in linkage disequilibrium, results in a small increase in susceptibility to schizophrenia.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00439/index.htmen_US
dc.relation.ispartofHuman Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshAntipsychotic Agents - Therapeutic Useen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshClozapine - Therapeutic Useen_US
dc.subject.meshDisease Susceptibilityen_US
dc.subject.meshGene Dosageen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshReceptors, Dopamine D3en_US
dc.subject.meshSchizophrenia - Drug Therapy - Ethnology - Geneticsen_US
dc.titleAllelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s004390050125en_US
dc.identifier.pmid8641685-
dc.identifier.scopuseid_2-s2.0-0030005962en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030005962&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume97en_US
dc.identifier.issue6en_US
dc.identifier.spage714en_US
dc.identifier.epage719en_US
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridShaikh, S=36485513100en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridBall, D=7202703810en_US
dc.identifier.scopusauthoridAitchison, K=7003415672en_US
dc.identifier.scopusauthoridVallada, H=7003742958en_US
dc.identifier.scopusauthoridSmith, I=7404425727en_US
dc.identifier.scopusauthoridGill, M=35228962600en_US
dc.identifier.scopusauthoridKerwin, RW=7102904567en_US

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