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- Publisher Website: 10.1007/s004390050125
- Scopus: eid_2-s2.0-0030005962
- PMID: 8641685
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Article: Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia
Title | Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia |
---|---|
Authors | |
Issue Date | 1996 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00439/index.htm |
Citation | Human Genetics, 1996, v. 97 n. 6, p. 714-719 How to Cite? |
Abstract | We examined a Ser-9-Gly polymorphism in the dopamine D3 receptor gene for allelic association with schizophrenia in 133 patients currently treated with clozapine and 109 controls. Allele 1 (Ser-9) was significantly more frequent in the patients (69%) than in the controls (56%) (P = 0.004). The 1-1 genotype was more common (43% vs 30%) and the 2-2 genotype less common (5% vs 18%) in patients than in controls. When the patient group was subdivided on the basis of clinical response to clozapine, using a 20-point improvement in the global assessment scale as cut-off, genotype 1-1 was found to be more frequent among the non-responders (53% vs 36%, P = 0.04). To place our results in the context of previous studies of this polymorphism and schizophrenia, we performed a meta-analysis of all published data including the present sample. The combined analysis shows evidence for a modest association between genotype 1-1 and schizophrenia (odds ratio 1.25, 95% confidence interval 1.05-1.49, P = 0.01). These results suggest that the Ser-9 allele, or a nearby polymorphism in linkage disequilibrium, results in a small increase in susceptibility to schizophrenia. |
Persistent Identifier | http://hdl.handle.net/10722/175754 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 2.049 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shaikh, S | en_US |
dc.contributor.author | Collier, DA | en_US |
dc.contributor.author | Sham, PC | en_US |
dc.contributor.author | Ball, D | en_US |
dc.contributor.author | Aitchison, K | en_US |
dc.contributor.author | Vallada, H | en_US |
dc.contributor.author | Smith, I | en_US |
dc.contributor.author | Gill, M | en_US |
dc.contributor.author | Kerwin, RW | en_US |
dc.date.accessioned | 2012-11-26T09:01:00Z | - |
dc.date.available | 2012-11-26T09:01:00Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Human Genetics, 1996, v. 97 n. 6, p. 714-719 | en_US |
dc.identifier.issn | 0340-6717 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/175754 | - |
dc.description.abstract | We examined a Ser-9-Gly polymorphism in the dopamine D3 receptor gene for allelic association with schizophrenia in 133 patients currently treated with clozapine and 109 controls. Allele 1 (Ser-9) was significantly more frequent in the patients (69%) than in the controls (56%) (P = 0.004). The 1-1 genotype was more common (43% vs 30%) and the 2-2 genotype less common (5% vs 18%) in patients than in controls. When the patient group was subdivided on the basis of clinical response to clozapine, using a 20-point improvement in the global assessment scale as cut-off, genotype 1-1 was found to be more frequent among the non-responders (53% vs 36%, P = 0.04). To place our results in the context of previous studies of this polymorphism and schizophrenia, we performed a meta-analysis of all published data including the present sample. The combined analysis shows evidence for a modest association between genotype 1-1 and schizophrenia (odds ratio 1.25, 95% confidence interval 1.05-1.49, P = 0.01). These results suggest that the Ser-9 allele, or a nearby polymorphism in linkage disequilibrium, results in a small increase in susceptibility to schizophrenia. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00439/index.htm | en_US |
dc.relation.ispartof | Human Genetics | en_US |
dc.subject.mesh | Alleles | en_US |
dc.subject.mesh | Antipsychotic Agents - Therapeutic Use | en_US |
dc.subject.mesh | Base Sequence | en_US |
dc.subject.mesh | Clozapine - Therapeutic Use | en_US |
dc.subject.mesh | Disease Susceptibility | en_US |
dc.subject.mesh | Gene Dosage | en_US |
dc.subject.mesh | Gene Frequency | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Molecular Sequence Data | en_US |
dc.subject.mesh | Polymorphism, Genetic | en_US |
dc.subject.mesh | Receptors, Dopamine D2 - Genetics | en_US |
dc.subject.mesh | Receptors, Dopamine D3 | en_US |
dc.subject.mesh | Schizophrenia - Drug Therapy - Ethnology - Genetics | en_US |
dc.title | Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_US |
dc.identifier.authority | Sham, PC=rp00459 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s004390050125 | en_US |
dc.identifier.pmid | 8641685 | - |
dc.identifier.scopus | eid_2-s2.0-0030005962 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030005962&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 97 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 714 | en_US |
dc.identifier.epage | 719 | en_US |
dc.publisher.place | Germany | en_US |
dc.identifier.scopusauthorid | Shaikh, S=36485513100 | en_US |
dc.identifier.scopusauthorid | Collier, DA=26642980600 | en_US |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_US |
dc.identifier.scopusauthorid | Ball, D=7202703810 | en_US |
dc.identifier.scopusauthorid | Aitchison, K=7003415672 | en_US |
dc.identifier.scopusauthorid | Vallada, H=7003742958 | en_US |
dc.identifier.scopusauthorid | Smith, I=7404425727 | en_US |
dc.identifier.scopusauthorid | Gill, M=35228962600 | en_US |
dc.identifier.scopusauthorid | Kerwin, RW=7102904567 | en_US |
dc.identifier.issnl | 0340-6717 | - |